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A3D1R5

- GSA_SHEB5

UniProt

A3D1R5 - GSA_SHEB5

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Sbal_1159
Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSBAL325240:GCTA-1184-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Sbal_1159
OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
Taxonomic identifieri325240 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001557: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_1000060000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi325240.Sbal_1159.

Structurei

3D structure databases

ProteinModelPortaliA3D1R5.
SMRiA3D1R5. Positions 2-423.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3D1R5-1 [UniParc]FASTAAdd to Basket

« Hide

MTRSEALFEQ AKKTIPGGVN SPVRAFNGVG GSPLFIEKAN GAYIYDADGK    50
AYIDYVGSWG PMILGHNHPK IRAAVLAAVE NGLSFGAPTE LEVQMAEKVI 100
SMVPSIEQVR MVSSGTEATM SAIRLARGFT NRDKILKFEG CYHGHADCLL 150
VKAGSGALTL GQPSSPGIPE DFAKHTLTAV YNDLDSVRTL FEQYPTDISC 200
IIIEPVAGNM NCIPPIPGFL QGLRDICDEF GALMIIDEVM TGFRVSQSGA 250
QGYYGVTPDL TTLGKVIGGG MPVGAFGGRK DVMQFIAPTG PVYQAGTLSG 300
NPIAMSAGLA QMEALCEEGL YEKLSAKTKR IAEGFKAAAD KHGIPMAINY 350
VGGMFGFFFT EQPEITRFDQ VTQCNIEQFR IFYHGMLDEG VYLAPSAYEA 400
GFLSMAHGEE EMRLTLEAAD RVLASMKAAS 430
Length:430
Mass (Da):46,095
Last modified:March 20, 2007 - v1
Checksum:i93DEADD8659E3AB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000563 Genomic DNA. Translation: ABN60678.1.
RefSeqiWP_011846147.1. NC_009052.1.
YP_001049547.1. NC_009052.1.

Genome annotation databases

EnsemblBacteriaiABN60678; ABN60678; Sbal_1159.
GeneIDi4845401.
KEGGisbl:Sbal_1159.
PATRICi37181115. VBISheBal55297_1409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000563 Genomic DNA. Translation: ABN60678.1 .
RefSeqi WP_011846147.1. NC_009052.1.
YP_001049547.1. NC_009052.1.

3D structure databases

ProteinModelPortali A3D1R5.
SMRi A3D1R5. Positions 2-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 325240.Sbal_1159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN60678 ; ABN60678 ; Sbal_1159 .
GeneIDi 4845401.
KEGGi sbl:Sbal_1159.
PATRICi 37181115. VBISheBal55297_1409.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci SBAL325240:GCTA-1184-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS155 / ATCC BAA-1091.

Entry informationi

Entry nameiGSA_SHEB5
AccessioniPrimary (citable) accession number: A3D1R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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