A3D186 (APAH_SHEB5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
EC=3.6.1.41

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase

Gene names

Name:	apaH
Ordered Locus Names:	Sbal_0975

Organism

Shewanella baltica (strain OS155 / ATCC BAA-1091) [Complete proteome] [HAMAP]

Taxonomic identifier

325240 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella baltica

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity. HAMAP-Rule MF_00199
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP-Rule MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP-Rule MF_00199		PRO_1000012088

Sequences

	Sequence		Length	Mass (Da)
	A3D186 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: EC6BD4302F1B95BA	FASTA	274	31,144
	10 20 30 40 50 60 MAHYFVGDIQ GCFAELQKLL AKVDFNPSRD ELWAVGDLVA RGPDSLATLR FFRSLGDSAK 70 80 90 100 110 120 TVLGNHDLHL MALHGKLKRA KPSDNLTEIL ESPDISASID WLRQQPLMRE LPEHQLIMSH 130 140 150 160 170 180 AGVPPQWSLE VLREEAALVS CALNQDDYLE ALISQMYSDS AEKWDPSAIG IERLRYCINA 190 200 210 220 230 240 LTRMRYLYVD GRLDFDCKQP PENCTNPQLK PWFEFASPLR QCHTLVFGHW AALMGNVGDT 250 260 270 KLKALDTGCC WGEHLTLWHL EKDQKITQKK LKKS

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS155." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Brettar I., Klappenbach J., Konstantinidis K., Rodrigues J., Tiedje J., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OS155 / ATCC BAA-1091.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000563 Genomic DNA. Translation: ABN60499.1.
RefSeq	YP_001049368.1. NC_009052.1.
3D structure databases
ProteinModelPortal	A3D186.
ModBase	Search...
Protein-protein interaction databases
STRING	325240.Sbal_0975.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN60499; ABN60499; Sbal_0975.
GeneID	4843307.
KEGG	sbl:Sbal_0975.
PATRIC	37180713. VBISheBal55297_1215.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0639.
HOGENOM	HOG000251871.
KO	K01525.
OMA	WLRHQPL.
ProtClustDB	PRK00166.
Family and domain databases
HAMAP	MF_00199. ApaH.
InterPro	IPR004617. ApaH. IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_SHEB5

Accession

Primary (citable) accession number: A3D186

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 20, 2007
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program