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A3D0F8

- ISPE_SHEB5

UniProt

A3D0F8 - ISPE_SHEB5

Protein

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene

ispE

Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.UniRule annotation

    Catalytic activityi

    ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei14 – 141UniRule annotation
    Active sitei140 – 1401UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi98 – 10811ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSBAL325240:GCTA-711-MONOMER.
    UniPathwayiUPA00056; UER00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
    Short name:
    CMKUniRule annotation
    Alternative name(s):
    4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseUniRule annotation
    Gene namesi
    Name:ispEUniRule annotation
    Ordered Locus Names:Sbal_0693
    OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
    Taxonomic identifieri325240 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2842844-diphosphocytidyl-2-C-methyl-D-erythritol kinasePRO_1000007886Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi325240.Sbal_0693.

    Structurei

    3D structure databases

    ProteinModelPortaliA3D0F8.
    SMRiA3D0F8. Positions 6-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1947.
    HOGENOMiHOG000019601.
    KOiK00919.
    OMAiVSTAEIF.
    OrthoDBiEOG62VNQ2.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00061. IspE.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010376. IspE. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00154. ispE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3D0F8-1 [UniParc]FASTAAdd to Basket

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    MPAAISRNWP APAKLNLFLH INGRRADGYH ALQTLFQFID CCDMLDFKVT    50
    ETPELILHSN MSGVVADSDN LILRAAKSLQ QTTGFNGGAE IWLDKRLPMG 100
    GGLGGGSSDA ATTLVALNKL WHTQLSTEEL AKIGLKLGAD IPVFIHGFAA 150
    FAEGVGERLQ AVNPSEPWYL VIAPDAHVST ADVFQDPLLP RETPKLAIDT 200
    LMSQPWANDC QKLVVSKYPQ VAKALGWLLE YAPSRMTGTG ACVFGEFTQQ 250
    QQALAALAKL PSEMQGFVAQ GMNLSPLITR LSHP 284
    Length:284
    Mass (Da):30,720
    Last modified:March 20, 2007 - v1
    Checksum:iEAF8A0024EE309EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000563 Genomic DNA. Translation: ABN60221.1.
    RefSeqiYP_001049090.1. NC_009052.1.

    Genome annotation databases

    EnsemblBacteriaiABN60221; ABN60221; Sbal_0693.
    GeneIDi4844025.
    KEGGisbl:Sbal_0693.
    PATRICi37180119. VBISheBal55297_0918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000563 Genomic DNA. Translation: ABN60221.1 .
    RefSeqi YP_001049090.1. NC_009052.1.

    3D structure databases

    ProteinModelPortali A3D0F8.
    SMRi A3D0F8. Positions 6-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 325240.Sbal_0693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN60221 ; ABN60221 ; Sbal_0693 .
    GeneIDi 4844025.
    KEGGi sbl:Sbal_0693.
    PATRICi 37180119. VBISheBal55297_0918.

    Phylogenomic databases

    eggNOGi COG1947.
    HOGENOMi HOG000019601.
    KOi K00919.
    OMAi VSTAEIF.
    OrthoDBi EOG62VNQ2.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00094 .
    BioCyci SBAL325240:GCTA-711-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00061. IspE.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010376. IspE. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00154. ispE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS155 / ATCC BAA-1091.

    Entry informationi

    Entry nameiISPE_SHEB5
    AccessioniPrimary (citable) accession number: A3D0F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3