Reviewed, UniProtKB/Swiss-Prot A3D007 (TPMT_SHEB5)

Names and origin

Protein names

Recommended name:
    Thiopurine S-methyltransferase
    EC=2.1.1.67
Alternative name(s):
    Thiopurine methyltransferase

Gene names

Name:	tpm
Ordered Locus Names:	Sbal_0541

Organism

Shewanella baltica (strain OS155 / ATCC BAA-1091) [Complete proteome] [HAMAP]

Taxonomic identifier

325240 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Thiopurine S-methyltransferase HAMAP MF_00812		PRO_1000047217
Sites
	Binding site	10	1	S-adenosyl-L-methionine By similarity
	Binding site	45	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	66	1	S-adenosyl-L-methionine By similarity
	Binding site	123	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3D007-1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: BBADF720FA1A218C	FASTA	218	24,836
	10 20 30 40 50 60 MEPGFWHEKW HQQQIGFHQQ DINPFLVKYW QQLGLPADTQ VFVPLCGKSL DMCFLAEQGH 70 80 90 100 110 120 QVIGCELNEL AVQQFFSDNQ LEMTQTTVGE HQHYQTEQIS LYQGDIFTLP NAITQEVTAF 130 140 150 160 170 180 YDRAALIAWP ESMRAQYAKQ LASLLPSGSV GLLVTLDYPQ EALIGPPFAV SPTWVEQHLS 190 200 210 DDFDIEVLAS QDVLADNPRF IKKAVPWLNE AAYLLKRK

References

[1]

"Complete sequence of chromosome of Shewanella baltica OS155." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Brettar I., Klappenbach J., Konstantinidis K., Rodrigues J., Tiedje J., Richardson P. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000563 Genomic DNA. Translation: ABN60070.1.
RefSeq	YP_001048939.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3D007.
Genome annotation databases
GeneID	4841795.
GenomeReviews	Gene locus Sbal_0541 in contig CP000563_GR.
KEGG	sbl:Sbal_0541.
NMPDR	fig|325240.3.peg.1635.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PPFAVSP.
Family and domain databases
HAMAP	MF_00812. [Tree]
InterPro	IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view]
Pfam	PF05724. TPMT. 1 hit. [Graphical view]
PIRSF	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPMT_SHEB5

Accession

Primary (citable) accession number: A3D007

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 20, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)