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A3CZY6

- FTHS_SHEB5

UniProt

A3CZY6 - FTHS_SHEB5

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSBAL325240:GCTA-534-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Sbal_0520
    OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
    Taxonomic identifieri325240 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001557: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Formate--tetrahydrofolate ligasePRO_1000068793Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi325240.Sbal_0520.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CZY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiKWNISYT.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CZY6-1 [UniParc]FASTAAdd to Basket

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    MLTDMDISSR ASLKNITEIG ADLGLLPEEM MLFGHTKAKV ELSVLQRLAG    50
    QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP 100
    VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
    ETRLGKTEFE AQSEQAFLDI DPNEIRWHRV VDHNDRCLRQ IHVGLGDNNG 200
    PEYESSFDIT AASELMAILA LSHDLADMRA RIGRLVLALN TQGQVITAED 250
    LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI 300
    ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN 350
    SGLATEVDSN VSNIHVPNIS ATNINAPDQA RLEAGFANLN WHINNVARYG 400
    IPVVVAINRF ATDSDAELQW LIEAVNASAA FGCEISDAFI QGEAGAIALA 450
    QTVVRAAETE SQFKLLYPDE ASLEAKLSTL AEVGYGATGV SLSIEAKQQA 500
    QQLTALGYGH LPLCMAKTPL SISHDPSLKG VPKDFVVPVR ELVLHAGAGF 550
    ITALVGNVMT MPGLGLKPGY LKIDIDAKGE IVGLG 585
    Length:585
    Mass (Da):61,594
    Last modified:March 20, 2007 - v1
    Checksum:iB7872220C21ED307
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000563 Genomic DNA. Translation: ABN60049.1.
    RefSeqiYP_001048918.1. NC_009052.1.

    Genome annotation databases

    EnsemblBacteriaiABN60049; ABN60049; Sbal_0520.
    GeneIDi4843046.
    KEGGisbl:Sbal_0520.
    PATRICi37179759. VBISheBal55297_0742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000563 Genomic DNA. Translation: ABN60049.1 .
    RefSeqi YP_001048918.1. NC_009052.1.

    3D structure databases

    ProteinModelPortali A3CZY6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 325240.Sbal_0520.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN60049 ; ABN60049 ; Sbal_0520 .
    GeneIDi 4843046.
    KEGGi sbl:Sbal_0520.
    PATRICi 37179759. VBISheBal55297_0742.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi KWNISYT.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SBAL325240:GCTA-534-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OS155 / ATCC BAA-1091.

    Entry informationi

    Entry nameiFTHS_SHEB5
    AccessioniPrimary (citable) accession number: A3CZY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3