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A3CZY6

- FTHS_SHEB5

UniProt

A3CZY6 - FTHS_SHEB5

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Sbal_0520
Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSBAL325240:GCTA-534-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Sbal_0520
OrganismiShewanella baltica (strain OS155 / ATCC BAA-1091)
Taxonomic identifieri325240 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001557: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000068793Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi325240.Sbal_0520.

Structurei

3D structure databases

ProteinModelPortaliA3CZY6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiKWNISYT.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CZY6-1 [UniParc]FASTAAdd to Basket

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MLTDMDISSR ASLKNITEIG ADLGLLPEEM MLFGHTKAKV ELSVLQRLAG    50
QRKGKLIIVT AVTPTPHGEG KTVTSIGLTQ SLNAIGQKAC ACIRQPSMGP 100
VFGVKGGAAG GGYAQVVPMQ EMNLHLTGDI HAVSSAHNLG AAAIAARLFH 150
ETRLGKTEFE AQSEQAFLDI DPNEIRWHRV VDHNDRCLRQ IHVGLGDNNG 200
PEYESSFDIT AASELMAILA LSHDLADMRA RIGRLVLALN TQGQVITAED 250
LGVAGAMTAI MADAIKPTLM QTLNGSPCLI HSGPFANIAH GNSSIIADDI 300
ALRLADFVVT EGGFGSDMGF EKFCNIKVRQ SGQAPAAAVL VTTLKALKAN 350
SGLATEVDSN VSNIHVPNIS ATNINAPDQA RLEAGFANLN WHINNVARYG 400
IPVVVAINRF ATDSDAELQW LIEAVNASAA FGCEISDAFI QGEAGAIALA 450
QTVVRAAETE SQFKLLYPDE ASLEAKLSTL AEVGYGATGV SLSIEAKQQA 500
QQLTALGYGH LPLCMAKTPL SISHDPSLKG VPKDFVVPVR ELVLHAGAGF 550
ITALVGNVMT MPGLGLKPGY LKIDIDAKGE IVGLG 585
Length:585
Mass (Da):61,594
Last modified:March 20, 2007 - v1
Checksum:iB7872220C21ED307
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000563 Genomic DNA. Translation: ABN60049.1.
RefSeqiYP_001048918.1. NC_009052.1.

Genome annotation databases

EnsemblBacteriaiABN60049; ABN60049; Sbal_0520.
GeneIDi4843046.
KEGGisbl:Sbal_0520.
PATRICi37179759. VBISheBal55297_0742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000563 Genomic DNA. Translation: ABN60049.1 .
RefSeqi YP_001048918.1. NC_009052.1.

3D structure databases

ProteinModelPortali A3CZY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 325240.Sbal_0520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN60049 ; ABN60049 ; Sbal_0520 .
GeneIDi 4843046.
KEGGi sbl:Sbal_0520.
PATRICi 37179759. VBISheBal55297_0742.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi KWNISYT.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SBAL325240:GCTA-534-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OS155 / ATCC BAA-1091.

Entry informationi

Entry nameiFTHS_SHEB5
AccessioniPrimary (citable) accession number: A3CZY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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