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Protein

Ribonuclease P protein component 4

Gene

rnp4

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63ZincUniRule annotation1
Metal bindingi66ZincUniRule annotation1
Metal bindingi89ZincUniRule annotation1
Metal bindingi92ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-1981-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component 4UniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P component 4UniRule annotation
Alternative name(s):
Rpp21UniRule annotation
Gene namesi
Name:rnp4UniRule annotation
Ordered Locus Names:Memar_1975
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000835051 – 105Ribonuclease P protein component 4Add BLAST105

Interactioni

Subunit structurei

Consists of a catalytic RNA component and at least 4-5 protein subunits.UniRule annotation

Protein-protein interaction databases

STRINGi368407.Memar_1975

Structurei

3D structure databases

ProteinModelPortaliA3CX01
SMRiA3CX01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic/archaeal RNase P protein component 4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04345 Archaea
COG2023 LUCA
HOGENOMiHOG000230709
KOiK03540
OMAiHVVITCL
OrthoDBiPOG093Z0K3G

Family and domain databases

HAMAPiMF_00757 RNase_P_4, 1 hit
InterProiView protein in InterPro
IPR016432 RNase_P_comp-4
IPR007175 Rpr2
PfamiView protein in Pfam
PF04032 Rpr2, 1 hit
PIRSFiPIRSF004878 RNase_P_4, 1 hit

Sequencei

Sequence statusi: Complete.

A3CX01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTTRKSGS RRLARERIAV LFARAAEFYP ESPDRSNRCV ELARKIGMRH
60 70 80 90 100
RIRIERPLKR RFCRRCYTYL VPGSNARVRV HRGRVVVTCL ACGHRSRFPV

GRPRQ
Length:105
Mass (Da):12,322
Last modified:March 20, 2007 - v1
Checksum:i2728FF3AADAEA985
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN57901.1
RefSeqiWP_011844810.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN57901; ABN57901; Memar_1975
GeneIDi4847390
KEGGimem:Memar_1975

Similar proteinsi

Entry informationi

Entry nameiRNP4_METMJ
AccessioniPrimary (citable) accession number: A3CX01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health