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Protein

D-3-phosphoglycerate dehydrogenase

Gene

Memar_1850

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH.UniRule annotation
3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH.UniRule annotation

Pathwayi: L-serine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (Memar_1850)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Serine biosynthesisUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

BioCyciMMAR368407:GH7L-1894-MONOMER.
UniPathwayiUPA00135; UER00196.

Names & Taxonomyi

Protein namesi
Recommended name:
D-3-phosphoglycerate dehydrogenaseUniRule annotation (EC:1.1.1.95UniRule annotation)
Gene namesi
Ordered Locus Names:Memar_1850Imported
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)Imported
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_1850.

Structurei

3D structure databases

ProteinModelPortaliA3CWM6.
SMRiA3CWM6. Positions 1-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini455 – 52773ACTInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Contains 1 ACT domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01754. Archaea.
COG0111. LUCA.
HOGENOMiHOG000136693.
KOiK00058.
OMAiEWKRSKF.

Family and domain databases

Gene3Di3.30.1330.90. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR002912. ACT_dom.
IPR029009. ASB_dom.
IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006236. PGDH.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
PF01842. ACT. 1 hit.
[Graphical view]
SUPFAMiSSF143548. SSF143548. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01327. PGDH. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CWM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYRVLVSDP LAEEGIDILR EFCDVDVNTG LTEDQLVAII GDYDGLLVRS
60 70 80 90 100
GTEVTAQVID AGAKLKFIGR AGAGVDNIDT DAATRRGIIV ANAPEGNTLA
110 120 130 140 150
ATEHTMAMML SLARNIPQAT ASLKKGEWKR SKFMGVELND KILGIMGFGR
160 170 180 190 200
IGREVAKRAQ AMQMKCIAYD PFITQERAAS LGVEMVPLDE LFRRADVITV
210 220 230 240 250
HTPLIKETRH VINAETIATM RDGVRLINCA RGGIIDEKAL ADAVASGKVA
260 270 280 290 300
GAALDVFENE PPTDSPLLGL DKVIVTPHLG ASTVEAQKNV AVSVANQCIS
310 320 330 340 350
VLSGGSAKYV VNAPMIPAEQ QALVEPYAML AQKMGSLLIQ LVEGRLESLE
360 370 380 390 400
ITYGGEAAGL PNTKFVTRVI LKGMLDPILQ VPANIVNAEF VAKERGIRMS
410 420 430 440 450
ETTTEEAQGF KNIITITAKT DRMTETVSGS VSGPNRARIV SIGGYMTDLT
460 470 480 490 500
PTGHVVISRH TDKPGVIGKA ATILGSVNVN IAGMQVGRNK PGEEALMVLT
510 520
VDSAVPADAM DEIKKIDGIH TAKHAEI
Length:527
Mass (Da):56,095
Last modified:March 20, 2007 - v1
Checksum:i899B545F242022C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN57776.1.
RefSeqiWP_011844685.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN57776; ABN57776; Memar_1850.
GeneIDi4848121.
KEGGimem:Memar_1850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN57776.1.
RefSeqiWP_011844685.1. NC_009051.1.

3D structure databases

ProteinModelPortaliA3CWM6.
SMRiA3CWM6. Positions 1-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368407.Memar_1850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN57776; ABN57776; Memar_1850.
GeneIDi4848121.
KEGGimem:Memar_1850.

Phylogenomic databases

eggNOGiarCOG01754. Archaea.
COG0111. LUCA.
HOGENOMiHOG000136693.
KOiK00058.
OMAiEWKRSKF.

Enzyme and pathway databases

UniPathwayiUPA00135; UER00196.
BioCyciMMAR368407:GH7L-1894-MONOMER.

Family and domain databases

Gene3Di3.30.1330.90. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR002912. ACT_dom.
IPR029009. ASB_dom.
IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006236. PGDH.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
PF01842. ACT. 1 hit.
[Graphical view]
SUPFAMiSSF143548. SSF143548. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01327. PGDH. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35101 / DSM 1498 / JR1Imported.

Entry informationi

Entry nameiA3CWM6_METMJ
AccessioniPrimary (citable) accession number: A3CWM6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 6, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.