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Protein

D-3-phosphoglycerate dehydrogenase

Gene

Memar_1850

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH.UniRule annotation

Pathwayi: L-serine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-3-phosphoglycerate dehydrogenase (Memar_1850)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Serine biosynthesisUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-1855-MONOMER
UniPathwayiUPA00135; UER00196

Names & Taxonomyi

Protein namesi
Recommended name:
D-3-phosphoglycerate dehydrogenaseUniRule annotation (EC:1.1.1.95UniRule annotation)
Gene namesi
Ordered Locus Names:Memar_1850Imported
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)Imported
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_1850

Structurei

3D structure databases

ProteinModelPortaliA3CWM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini455 – 527ACTInterPro annotationAdd BLAST73

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01754 Archaea
COG0111 LUCA
HOGENOMiHOG000136693
KOiK00058
OMAiNIAGMQV
OrthoDBiPOG093Z0DW1

Family and domain databases

Gene3Di3.30.1330.90, 1 hit
InterProiView protein in InterPro
IPR002912 ACT_dom
IPR029009 ASB_dom_sf
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR006236 PGDH
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
PF01842 ACT, 1 hit
SUPFAMiSSF143548 SSF143548, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01327 PGDH, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

A3CWM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYRVLVSDP LAEEGIDILR EFCDVDVNTG LTEDQLVAII GDYDGLLVRS
60 70 80 90 100
GTEVTAQVID AGAKLKFIGR AGAGVDNIDT DAATRRGIIV ANAPEGNTLA
110 120 130 140 150
ATEHTMAMML SLARNIPQAT ASLKKGEWKR SKFMGVELND KILGIMGFGR
160 170 180 190 200
IGREVAKRAQ AMQMKCIAYD PFITQERAAS LGVEMVPLDE LFRRADVITV
210 220 230 240 250
HTPLIKETRH VINAETIATM RDGVRLINCA RGGIIDEKAL ADAVASGKVA
260 270 280 290 300
GAALDVFENE PPTDSPLLGL DKVIVTPHLG ASTVEAQKNV AVSVANQCIS
310 320 330 340 350
VLSGGSAKYV VNAPMIPAEQ QALVEPYAML AQKMGSLLIQ LVEGRLESLE
360 370 380 390 400
ITYGGEAAGL PNTKFVTRVI LKGMLDPILQ VPANIVNAEF VAKERGIRMS
410 420 430 440 450
ETTTEEAQGF KNIITITAKT DRMTETVSGS VSGPNRARIV SIGGYMTDLT
460 470 480 490 500
PTGHVVISRH TDKPGVIGKA ATILGSVNVN IAGMQVGRNK PGEEALMVLT
510 520
VDSAVPADAM DEIKKIDGIH TAKHAEI
Length:527
Mass (Da):56,095
Last modified:March 20, 2007 - v1
Checksum:i899B545F242022C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN57776.1
RefSeqiWP_011844685.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN57776; ABN57776; Memar_1850
GeneIDi4848121
KEGGimem:Memar_1850

Similar proteinsi

Entry informationi

Entry nameiA3CWM6_METMJ
AccessioniPrimary (citable) accession number: A3CWM6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health