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A3CWM4

- MFNA_METMJ

UniProt

A3CWM4 - MFNA_METMJ

Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

    Catalytic activityi

    L-tyrosine = tyramine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: UniProtKB-HAMAP
    2. tyrosine decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. coenzyme biosynthetic process Source: UniProtKB-HAMAP
    2. tyrosine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMMAR368407:GH7L-1892-MONOMER.
    UniPathwayiUPA00080.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
    Short name:
    TDCUniRule annotation
    Gene namesi
    Name:mfnAUniRule annotation
    Ordered Locus Names:Memar_1848
    OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
    Taxonomic identifieri368407 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
    ProteomesiUP000002146: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 365365L-tyrosine decarboxylasePRO_0000293185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei224 – 2241N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi368407.Memar_1848.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CWM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000246269.
    KOiK01592.
    OMAiKLVWAEL.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_01610. Tyr_decarbox.
    InterProiIPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    IPR020931. Tyr_deCO2ase.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CWM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREVGCPEED LFSFLSSKRR EDLGYRNILS SMCTPPHPVA ARAHAMFLET    50
    NLGDPGLFPG TAALEDLLVR RLGTLMHLPD AGGYATSGGT ESNIQAFRIA 100
    KKLKSAKSPN VVVPASSHFS FTKACDILGL EMRTVPLDAG FRMETEAVDG 150
    LIDHNTVALV GVVGTTEYGM VDPISRLSEI ALDRNVFLHV DAAFGGMVVP 200
    FLDRPVPFDF SLPGVSSISV DPHKMGMSTI PAGCLLTRSA EWFSCLNVDT 250
    PYLTVKRECT LAGTRPGASV AAAIAVLEYL GMDGMRAVVA GCMENCRRLI 300
    EGMETLGYPR AVTPDVNVAT FSCERAPVGW RVSTTRNGHM RIVCMPHVTR 350
    DVVEQFLVDM GDTDA 365
    Length:365
    Mass (Da):39,401
    Last modified:March 20, 2007 - v1
    Checksum:iBB4D126014B8497B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000562 Genomic DNA. Translation: ABN57774.1.
    RefSeqiYP_001047756.1. NC_009051.1.

    Genome annotation databases

    EnsemblBacteriaiABN57774; ABN57774; Memar_1848.
    GeneIDi4845930.
    KEGGimem:Memar_1848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000562 Genomic DNA. Translation: ABN57774.1 .
    RefSeqi YP_001047756.1. NC_009051.1.

    3D structure databases

    ProteinModelPortali A3CWM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368407.Memar_1848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN57774 ; ABN57774 ; Memar_1848 .
    GeneIDi 4845930.
    KEGGi mem:Memar_1848.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000246269.
    KOi K01592.
    OMAi KLVWAEL.

    Enzyme and pathway databases

    UniPathwayi UPA00080 .
    BioCyci MMAR368407:GH7L-1892-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_01610. Tyr_decarbox.
    InterProi IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    IPR020931. Tyr_deCO2ase.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03812. tyr_de_CO2_Arch. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35101 / DSM 1498 / JR1.

    Entry informationi

    Entry nameiMFNA_METMJ
    AccessioniPrimary (citable) accession number: A3CWM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3