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Protein

L-tyrosine decarboxylase

Gene

mfnA

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMMAR368407:GH7L-1892-MONOMER.
UniPathwayiUPA00080.

Names & Taxonomyi

Protein namesi
Recommended name:
L-tyrosine decarboxylaseUniRule annotation (EC:4.1.1.25UniRule annotation)
Short name:
TDCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:Memar_1848
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
ProteomesiUP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365L-tyrosine decarboxylasePRO_0000293185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei224 – 2241N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi368407.Memar_1848.

Structurei

3D structure databases

ProteinModelPortaliA3CWM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK18933.
OMAiTEYGMVD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVGCPEED LFSFLSSKRR EDLGYRNILS SMCTPPHPVA ARAHAMFLET
60 70 80 90 100
NLGDPGLFPG TAALEDLLVR RLGTLMHLPD AGGYATSGGT ESNIQAFRIA
110 120 130 140 150
KKLKSAKSPN VVVPASSHFS FTKACDILGL EMRTVPLDAG FRMETEAVDG
160 170 180 190 200
LIDHNTVALV GVVGTTEYGM VDPISRLSEI ALDRNVFLHV DAAFGGMVVP
210 220 230 240 250
FLDRPVPFDF SLPGVSSISV DPHKMGMSTI PAGCLLTRSA EWFSCLNVDT
260 270 280 290 300
PYLTVKRECT LAGTRPGASV AAAIAVLEYL GMDGMRAVVA GCMENCRRLI
310 320 330 340 350
EGMETLGYPR AVTPDVNVAT FSCERAPVGW RVSTTRNGHM RIVCMPHVTR
360
DVVEQFLVDM GDTDA
Length:365
Mass (Da):39,401
Last modified:March 20, 2007 - v1
Checksum:iBB4D126014B8497B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN57774.1.
RefSeqiWP_011844683.1. NC_009051.1.
YP_001047756.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN57774; ABN57774; Memar_1848.
GeneIDi4845930.
KEGGimem:Memar_1848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN57774.1.
RefSeqiWP_011844683.1. NC_009051.1.
YP_001047756.1. NC_009051.1.

3D structure databases

ProteinModelPortaliA3CWM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368407.Memar_1848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN57774; ABN57774; Memar_1848.
GeneIDi4845930.
KEGGimem:Memar_1848.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000246269.
KOiK18933.
OMAiTEYGMVD.

Enzyme and pathway databases

UniPathwayiUPA00080.
BioCyciMMAR368407:GH7L-1892-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_01610. Tyr_decarbox.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
IPR020931. Tyr_deCO2ase.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03812. tyr_de_CO2_Arch. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35101 / DSM 1498 / JR1.

Entry informationi

Entry nameiMFNA_METMJ
AccessioniPrimary (citable) accession number: A3CWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: May 27, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.