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Protein

Probable L-tyrosine/L-aspartate decarboxylase

Gene

mfnA

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation
L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: methanofuran biosynthesis

This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.

Pathwayi: coenzyme A biosynthesis

This protein is involved in the pathway coenzyme A biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-1853-MONOMER
UniPathwayiUPA00080
UPA00241

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-tyrosine/L-aspartate decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation, EC:4.1.1.25UniRule annotation)
Short name:
TDC/ADCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:Memar_1848
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931851 – 365Probable L-tyrosine/L-aspartate decarboxylaseAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_1848

Structurei

3D structure databases

ProteinModelPortaliA3CWM4
SMRiA3CWM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. MfnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00027 Archaea
COG0076 LUCA
HOGENOMiHOG000246269
KOiK18933
OMAiDPHKMGL
OrthoDBiPOG093Z06IK

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01610 MfnA_decarbox, 1 hit
InterProiView protein in InterPro
IPR020931 MfnA
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03812 tyr_de_CO2_Arch, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

A3CWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREVGCPEED LFSFLSSKRR EDLGYRNILS SMCTPPHPVA ARAHAMFLET
60 70 80 90 100
NLGDPGLFPG TAALEDLLVR RLGTLMHLPD AGGYATSGGT ESNIQAFRIA
110 120 130 140 150
KKLKSAKSPN VVVPASSHFS FTKACDILGL EMRTVPLDAG FRMETEAVDG
160 170 180 190 200
LIDHNTVALV GVVGTTEYGM VDPISRLSEI ALDRNVFLHV DAAFGGMVVP
210 220 230 240 250
FLDRPVPFDF SLPGVSSISV DPHKMGMSTI PAGCLLTRSA EWFSCLNVDT
260 270 280 290 300
PYLTVKRECT LAGTRPGASV AAAIAVLEYL GMDGMRAVVA GCMENCRRLI
310 320 330 340 350
EGMETLGYPR AVTPDVNVAT FSCERAPVGW RVSTTRNGHM RIVCMPHVTR
360
DVVEQFLVDM GDTDA
Length:365
Mass (Da):39,401
Last modified:March 20, 2007 - v1
Checksum:iBB4D126014B8497B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN57774.1
RefSeqiWP_011844683.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN57774; ABN57774; Memar_1848
GeneIDi4845930
KEGGimem:Memar_1848

Similar proteinsi

Entry informationi

Entry nameiMFNA_METMJ
AccessioniPrimary (citable) accession number: A3CWM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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