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Protein

tRNA (guanine(26)-N(2))-dimethyltransferase

Gene

trm1

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.UniRule annotation

Catalytic activityi

2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L-homocysteine + N2-dimethylguanine(26) in tRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-1697-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine(26)-N(2))-dimethyltransferaseUniRule annotation (EC:2.1.1.216UniRule annotation)
Alternative name(s):
tRNA 2,2-dimethylguanosine-26 methyltransferaseUniRule annotation
tRNA(guanine-26,N(2)-N(2)) methyltransferaseUniRule annotation
tRNA(m(2,2)G26)dimethyltransferaseUniRule annotation
Gene namesi
Name:trm1UniRule annotation
Ordered Locus Names:Memar_1698
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001970341 – 371tRNA (guanine(26)-N(2))-dimethyltransferaseAdd BLAST371

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_1698

Structurei

3D structure databases

ProteinModelPortaliA3CW75
SMRiA3CW75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 368Trm1 methyltransferaseUniRule annotationAdd BLAST365

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01219 Archaea
COG1867 LUCA
HOGENOMiHOG000229931
KOiK00555
OMAiVFYNPVM
OrthoDBiPOG093Z0BNY

Family and domain databases

HAMAPiMF_00290 tRNA_dimethyltr_TRM1, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR002905 Trm1
IPR022923 TRM1_arc_bac
PANTHERiPTHR10631 PTHR10631, 1 hit
PfamiView protein in Pfam
PF02005 TRM, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00308 TRM1, 1 hit
PROSITEiView protein in PROSITE
PS51626 SAM_MT_TRM1, 1 hit

Sequencei

Sequence statusi: Complete.

A3CW75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVEVTEGR TRFFVSRQDP HLQFPPGSGQ VFYNSRMEMN RDATVLLLSV
60 70 80 90 100
LRPESYLDAM GASGVRGLRV AHEVGIPVTI NDWNAKAVDL ARQNVEALGL
110 120 130 140 150
VAEVTHGDAN VLMSGRTFDA VDLDPFGTPA PFVDSAARSA GNYLFVTATD
160 170 180 190 200
TAPLCGAHLK AGMRRYFSRP RNTEYHAEVG LRTLMGFVVR EVIKYDRGVE
210 220 230 240 250
PLFCYAHEHF HRLHLRLRYG AAAADRALAR IGYVMQCPNC LYRSEQTGML
260 270 280 290 300
PEPEECPLCS AALVPVGPLW TGGINDDATL AAMQEALPSV TAGTGARIGR
310 320 330 340 350
LLATCRQELD TSSHYDYHVI AKRLRVSPGR IETVIERLVA LGYRASRAHY
360 370
SGTALKTDAP LPVLEKVVSG G
Length:371
Mass (Da):40,568
Last modified:March 20, 2007 - v1
Checksum:i1A9112ED885A852C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN57625.1
RefSeqiWP_011844536.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN57625; ABN57625; Memar_1698
GeneIDi4848285
KEGGimem:Memar_1698

Similar proteinsi

Entry informationi

Entry nameiTRM1_METMJ
AccessioniPrimary (citable) accession number: A3CW75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health