A3CVD7 (A3CVD7_METMJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897
Ordered Locus Names:	Memar_1408

Organism

Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) [Complete proteome] [HAMAP]

Taxonomic identifier

368407 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus

Protein attributes

Sequence length	811 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01897
Ligand	ATP-binding HAMAP MF_01897 DNA-binding HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3CVD7 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 4D87267FFB2C5B7D	FASTA	811	90,145
	10 20 30 40 50 60 MTSEGEGVVP INIEEEMKSC YIDYAMSVII GRAIPDARDG LKPVHRRTLY AMWEMGNTSD 70 80 90 100 110 120 KPYKKSARIV GDVMGKYHPH GDSAIYDTLV KMAQPFSYRC MLVDGQGNFG SIDGDSAAAM 130 140 150 160 170 180 RYTEARLTKI SEELLTDIDK KTVDFVPNFD ESLQEPSVLP ARIPNLLVNG SSGIAVGMAT 190 200 210 220 230 240 NMPPHNLREV CEATCRVIDD AGTSTEELMQ VMPGPDFPTG GIMMGTAGIR DAYLTGRGKC 250 260 270 280 290 300 VVRGVAEIEE EGRTPQIIIT EIPFQVNKAR LIEHIASLVR DKRIEGIGDI RDESDRDGMR 310 320 330 340 350 360 IVVELKRGAA PQVILNFLYK HTALESSFGI INLAIVDRQP RTLNLKEIIH EFLKHRVDVV 370 380 390 400 410 420 RRRTEFDLTK NEERMHILRG LLVALDNIDA VIATIRGSGT TDEAQKALVA KFALDEVQAD 430 440 450 460 470 480 AILKMQLRRL AALEHQKILD ERDAIAAEIE RLSAILASEA SILAEIKKEL VDIGARFGDE 490 500 510 520 530 540 RRTRIAQAAE AFDREDLIED KPVLVSLTSS NYVKRIDLDT YRNQRRGGHG VIGMATKDND 550 560 570 580 590 600 GVEKVFVANM HDNLLCFTDR GRMYWLKIYD LPEGQRTGKG KALVNLLNLD GEERVTTVIP 610 620 630 640 650 660 VREYRPDHHL FFATRNGTVA KMALDEFSRP RQTGINAINL RDGDALVDVK ATDGNQELIL 670 680 690 700 710 720 TTKFGQSLRF HEEAVRPVHR NAMGVRGIKL RHGDALQAIA IVEDDHLLTI TEQGYGKRTE 730 740 750 760 770 780 FDEYRGHGRG TLGVRNIVVD ARAGNVVGSM AVSDDDEIIV MSASGIVIRT KVSEISIQKR 790 800 810 GTRGVRVMKL DDGDRVIGFT ILDSEEPEEE A

References

[1]

"Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1." Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., Land M. , Lucas S., Richardson P., Whitman W., Kyrpides N.C. Stand. Genomic Sci. 1:189-196(2009) [PubMed: 21304656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35101 / DSM 1498 / JR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000562 Genomic DNA. Translation: ABN57337.1.
RefSeq	YP_001047319.1. NC_009051.1.
3D structure databases
ProteinModelPortal	A3CVD7.
SMR	A3CVD7. Positions 30-486.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CVD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4846971.
GenomeReviews	Gene locus Memar_1408 in contig CP000562_GR.
KEGG	mem:Memar_1408.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05278.
HOGENOM	HBG635183.
OMA	TGRGRIY.
PhylomeDB	A3CVD7.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 2 hits.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A3CVD7_METMJ

Accession

Primary (citable) accession number: A3CVD7

Entry history

Integrated into UniProtKB/TrEMBL:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)