A3CVB4 (SURE_METMJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Memar_1385

Organism

Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) [Complete proteome] [HAMAP]

Taxonomic identifier

368407 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	5'-nucleotidase surE HAMAP MF_00060		PRO_0000335297
Sites
	Metal binding	10	1	Divalent metal cation By similarity
	Metal binding	11	1	Divalent metal cation By similarity
	Metal binding	41	1	Divalent metal cation By similarity
	Metal binding	95	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3CVB4 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 2B16C57249034CE0	FASTA	263	28,286
	10 20 30 40 50 60 MKPKILLTND DGITSTGLWA AYDALAPIAD VTVVAPATQQ SAVGRSISIF EPIRANQVTM 70 80 90 100 110 120 NGVTAYSVGG KPTDAVIIGL FALRLNPDLV VSGVNIGENL SFESIMTSGT VGAALEAANQ 130 140 150 160 170 180 GVPSLAFSLQ VEDQGDKFDD PSRIIDRYSD AKRVVRETCE RVLANGFPGK AHVINVNIPA 190 200 210 220 230 240 RVRGGYEITR LAEKLFYTGV EERLDPRGRP YYWIDGPLYE DAEEGTDVHA VQRGNVSITP 250 260 ITLDCTAYAA ADELKAIFDG MHI

References

[1]

"Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1." Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., Land M. , Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:189-196(2009) [PubMed: 21304656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35101 / DSM 1498 / JR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000562 Genomic DNA. Translation: ABN57314.1.
RefSeq	YP_001047296.1. NC_009051.1.
3D structure databases
ProteinModelPortal	A3CVB4.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CVB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4846964.
GenomeReviews	Gene locus Memar_1385 in contig CP000562_GR.
KEGG	mem:Memar_1385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05083.
HOGENOM	HBG600532.
OMA	NGFYYVN.
PhylomeDB	A3CVB4.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	MMAR368407:MEMAR_1385-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_METMJ

Accession

Primary (citable) accession number: A3CVB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 20, 2007
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program