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A3CV55

- A3CV55_METMJ

UniProt

A3CV55 - A3CV55_METMJ

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, Memar_1325
Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Substrate By similarityUniRule annotation
Metal bindingi178 – 1781Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi180 – 1801Magnesium By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Active sitei270 – 2701Proton acceptor By similarityUniRule annotation
Binding sitei271 – 2711Substrate By similarityUniRule annotation
Binding sitei303 – 3031Substrate By similarityUniRule annotation
Sitei310 – 3101Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMMAR368407:GH7L-1351-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Memar_1325Imported
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)Imported
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
ProteomesiUP000002146: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi368407.Memar_1325.

Structurei

3D structure databases

ProteinModelPortaliA3CV55.
SMRiA3CV55. Positions 3-428.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni353 – 3553Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CV55-1 [UniParc]FASTAAdd to Basket

« Hide

MAIDWYEEFV DLNHTPGPDE LVALYYFEPA AGISKEEAVG RIASESSTGT    50
WTTLFTLPPR MRDLQAKAFE IEGNYVKIAY PLALWEEGNA AQLLSGIAGN 100
VFGMKALDRL RLIDASLPAE YLRHFKGPHF GMEGIRDMMK IRGRPLTGAV 150
PKPKVGFTAE EHAEVGYETW MGGFDFVKDD ENLTSQSFNR FDDRVRAMAK 200
MRDRAEQETG DVKSAFINIT ADTETMEKRA KMLADYGWNY AMIDVVVAGT 250
AAVATLRDYC SDLGLAIHAH RAMHAAFDRD EKHGITMQFL AKMMRLVGVA 300
QIHTGTAVGK LVGTRAEATV LADMLREKHT NAVDHMALDQ DWGNIKSAFP 350
VSSGGLHPGL VPDVLDIYGS ELVLLVSGGI HGHPKGTRAG AEAAMQAIEA 400
WKEGETLEEK AKKAPALSEA LEKWGRYKPK 430
Length:430
Mass (Da):47,331
Last modified:March 20, 2007 - v1
Checksum:i08D87E9C4B244477
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000562 Genomic DNA. Translation: ABN57255.1.
RefSeqiYP_001047237.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN57255; ABN57255; Memar_1325.
GeneIDi4848035.
KEGGimem:Memar_1325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000562 Genomic DNA. Translation: ABN57255.1 .
RefSeqi YP_001047237.1. NC_009051.1.

3D structure databases

ProteinModelPortali A3CV55.
SMRi A3CV55. Positions 3-428.
ModBasei Search...

Protein-protein interaction databases

STRINGi 368407.Memar_1325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN57255 ; ABN57255 ; Memar_1325 .
GeneIDi 4848035.
KEGGi mem:Memar_1325.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci MMAR368407:GH7L-1351-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR020878. RuBisCo_large_chain_AS.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35101 / DSM 1498 / JR1.

Entry informationi

Entry nameiA3CV55_METMJ
AccessioniPrimary (citable) accession number: A3CV55
Entry historyi
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi