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A3CUF2

- CIMA_METMJ

UniProt

A3CUF2 - CIMA_METMJ

Protein

Putative (R)-citramalate synthase CimA

Gene

cimA

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + pyruvate + H2O = CoA + (2R)-2-hydroxy-2-methylbutanedioate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. (R)-citramalate synthase activity Source: InterPro
    2. 2-isopropylmalate synthase activity Source: InterPro
    3. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. leucine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Isoleucine biosynthesis

    Enzyme and pathway databases

    BioCyciMMAR368407:GH7L-1088-MONOMER.
    UniPathwayiUPA00047; UER00066.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative (R)-citramalate synthase CimAUniRule annotation (EC:2.3.1.182UniRule annotation)
    Gene namesi
    Name:cimAUniRule annotation
    Ordered Locus Names:Memar_1069
    OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
    Taxonomic identifieri368407 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
    ProteomesiUP000002146: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Putative (R)-citramalate synthase CimAPRO_0000407913Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi368407.Memar_1069.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CUF2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-IPM synthase/homocitrate synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0119.
    HOGENOMiHOG000046859.
    KOiK09011.
    OMAiTPIASVK.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01028. CimA.
    InterProiIPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR024890. Citramalate_synthase_CimA.
    IPR011830. LEU1_arch.
    IPR000891. PYR_CT.
    [Graphical view]
    PfamiPF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view]
    SMARTiSM00917. LeuA_dimer. 1 hit.
    [Graphical view]
    SUPFAMiSSF110921. SSF110921. 1 hit.
    TIGRFAMsiTIGR02090. LEU1_arch. 1 hit.
    PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CUF2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVLFVEPIR FFDTTLRDGE QTPGVSLTPA GKLEIATHLA DVGVHVIEAG    50
    SAAASVGERE SIRAIADAGL AAECCTYVRA LPGDIDLAAD AGADSVHLVV 100
    PVSDLHIAKK LRKTREQVSE MAWSAVEYAK ERGLVVELSG EDASRADQDF 150
    LAEVFREGVE RGADRLCFCD TVGLLTPERA AAIIPPLLFA PLSIHCHDDL 200
    GFGLATTVAA LRAGATCAHV TVNGLGERAG NTSLEELVMA LEVLYGVDTG 250
    IATEELYPLS THVARLTGVP LATNKPIVGE MAFTHESGIH AHGVMRDAST 300
    YEPLQPERVG RRRRIVLGKH SGSAAVEAAL HDMGYAPSAA QLKEIVDRIK 350
    RLGDAGMRIT DADIMAIADT VMEIEFTPCI ELRQFTIVSG SNAIPTASVT 400
    MLVRGEEITG AAVGTGPVDA AIRALQRSVA DVGSVRLDEY SVDAITGGTD 450
    ALVDVSVKLS KDGKTVTSRG ARTDIIMASV EAVIAGMNRL LREEHEDRSQ 500
    DSD 503
    Length:503
    Mass (Da):53,275
    Last modified:March 20, 2007 - v1
    Checksum:iEA9E955BCE0B7118
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000562 Genomic DNA. Translation: ABN57002.1.
    RefSeqiWP_011843913.1. NC_009051.1.
    YP_001046984.1. NC_009051.1.

    Genome annotation databases

    EnsemblBacteriaiABN57002; ABN57002; Memar_1069.
    GeneIDi4847429.
    KEGGimem:Memar_1069.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000562 Genomic DNA. Translation: ABN57002.1 .
    RefSeqi WP_011843913.1. NC_009051.1.
    YP_001046984.1. NC_009051.1.

    3D structure databases

    ProteinModelPortali A3CUF2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368407.Memar_1069.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN57002 ; ABN57002 ; Memar_1069 .
    GeneIDi 4847429.
    KEGGi mem:Memar_1069.

    Phylogenomic databases

    eggNOGi COG0119.
    HOGENOMi HOG000046859.
    KOi K09011.
    OMAi TPIASVK.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00066 .
    BioCyci MMAR368407:GH7L-1088-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01028. CimA.
    InterProi IPR013709. 2-isopropylmalate_synth_dimer.
    IPR002034. AIPM/Hcit_synth_CS.
    IPR013785. Aldolase_TIM.
    IPR024890. Citramalate_synthase_CimA.
    IPR011830. LEU1_arch.
    IPR000891. PYR_CT.
    [Graphical view ]
    Pfami PF00682. HMGL-like. 1 hit.
    PF08502. LeuA_dimer. 1 hit.
    [Graphical view ]
    SMARTi SM00917. LeuA_dimer. 1 hit.
    [Graphical view ]
    SUPFAMi SSF110921. SSF110921. 1 hit.
    TIGRFAMsi TIGR02090. LEU1_arch. 1 hit.
    PROSITEi PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
    PS00816. AIPM_HOMOCIT_SYNTH_2. 1 hit.
    PS50991. PYR_CT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35101 / DSM 1498 / JR1.

    Entry informationi

    Entry nameiCIMA_METMJ
    AccessioniPrimary (citable) accession number: A3CUF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3