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Protein

NAD kinase

Gene

nadK

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Proton acceptorUniRule annotation1
Binding sitei142NADUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei161NADUniRule annotation1
Binding sitei196NAD; via carbonyl oxygenUniRule annotation1
Binding sitei230NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 64NADUniRule annotation2
Nucleotide bindingi131 – 132NADUniRule annotation2
Nucleotide bindingi172 – 177NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-970-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Memar_0968
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000598801 – 270NAD kinaseAdd BLAST270

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0968

Structurei

3D structure databases

ProteinModelPortaliA3CU51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348 Archaea
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A3CU51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVLVSRID EADALRYTAS LARELEGLGH EVALEEGTAA HLGEGGISFE
60 70 80 90 100
EIDGDLVVVV GGDGSVLLTV HQMKKQVPVL GINWGEVGFL ADLEPDEAGT
110 120 130 140 150
FFAAHTEGFH IERRMRVSLS VNGVPLGDAL NEGLVVTDRP AKMLRFGVYV
160 170 180 190 200
DGTPAERFRA DGLLVSTPTG STAYAMSAGG PIVDPQIEGF LLVPLAPYML
210 220 230 240 250
SSRPHLISTG RNLEITLETE KPAHLVIDGQ STFELEKEAT LTVKKSDQPA
260 270
LFVHTGKPFF EKVNHKLRNL
Length:270
Mass (Da):29,135
Last modified:March 20, 2007 - v1
Checksum:iB2A5C11BB1101CBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN56901.1
RefSeqiWP_011843812.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN56901; ABN56901; Memar_0968
GeneIDi4845934
KEGGimem:Memar_0968

Similar proteinsi

Entry informationi

Entry nameiNADK_METMJ
AccessioniPrimary (citable) accession number: A3CU51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health