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A3CTT5 (ARLY_METMJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Memar_0852
OrganismMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) [Complete proteome] [HAMAP]
Taxonomic identifier368407 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Argininosuccinate lyase HAMAP MF_00006
PRO_1000000502

Sequences

Sequence LengthMass (Da)Tools
A3CTT5 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 5B0872B04036A58B

FASTA49253,393
        10         20         30         40         50         60 
MRSDQIRQGR LAGERSGDLE HFLASMDADR WIARADLLVD MAHLLGLSRQ GIIDEAPARA 

        70         80         90        100        110        120 
LMAALLDLYD HGVPEEAFDE RFEDVHAGKE AYLIDRVGED FGGRLHMGRS RNDEVATCIR 

       130        140        150        160        170        180 
IRLKEEIIAL LRSLVDLRAT LLDVAAGHTG TVMPGFTHLQ HAQPTTLAHY LLAYEQAFSR 

       190        200        210        220        230        240 
DTARLREAYA RVDVSPLGSA AFASTGFPLD RAYTASLLGF SRPAGNSMDA VAARDFAIEV 

       250        260        270        280        290        300 
LADASICMTS TSRLCEELVL WSTAFVGFVR LDDAYCSSSS IMPQKKNPDV AEIMRAKAGS 

       310        320        330        340        350        360 
VAGSLAAAIT ITKGLPMSYN RDLQELTPHL WRGVEAARQS IPLLSGMLGS ATFDAERMAA 

       370        380        390        400        410        420 
EAGRGFSTAT ELADVLVREY GLPFRTAHRI VGRAVRHGSL DLATLEAAAR EAADFSVVEL 

       430        440        450        460        470        480 
GLTREKIDAV LDPRHAVAVR NIVGGPAPEA VAAQISEQRN LLARDKAWAE ETESALSGAF 

       490 
EHLILEARRF AA

« Hide

References

[1]"Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1."
Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., Land M. expand/collapse author list , Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.
Stand. Genomic Sci. 1:189-196(2009) [PubMed: 21304656] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35101 / DSM 1498 / JR1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000562 Genomic DNA. Translation: ABN56785.1.
RefSeqYP_001046767.1. NC_009051.1.

3D structure databases

ProteinModelPortalA3CTT5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3CTT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4847711.
GenomeReviewsGene locus Memar_0852 in contig CP000562_GR.
KEGGmem:Memar_0852.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04975.
HOGENOMHBG539632.
OMAEDIHTVI.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycMMAR368407:MEMAR_0852-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_METMJ
AccessionPrimary (citable) accession number: A3CTT5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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