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A3CTS0 (A3CTS0_METMJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase 1 HAMAP MF_00079
Short name=ATP-PRT 1 HAMAP MF_00079
Short name=ATP-PRTase 1 HAMAP MF_00079
EC=2.4.2.17 HAMAP MF_00079
Gene names
Name:hisG1 HAMAP MF_00079
Ordered Locus Names:Memar_0837
OrganismMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) [Complete proteome] [HAMAP]
Taxonomic identifier368407 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity By similarity. HAMAP MF_00079

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00079

Cofactor

Magnesium By similarity. HAMAP MF_00079

Enzyme regulation

Feedback inhibited by histidine By similarity. HAMAP MF_00079

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_00079

Subcellular location

Cytoplasm By similarity HAMAP MF_00079.

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily. HAMAP MF_00079

Sequences

Sequence LengthMass (Da)Tools
A3CTS0 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: ED30FB76223621B1

FASTA30031,944
        10         20         30         40         50         60 
MSKPSPRHPV PGPGLVRLAI PNKGRISGPI NELIEKSGLH LAEGGSERRL ITRTRDPNVE 

        70         80         90        100        110        120 
ILFARPIDIP EYVASGVADL GITGKDMVME RGSAVEQVLD LQTGKATLVV AVPEESDIET 

       130        140        150        160        170        180 
VADLAGAKVA TEFPAITRAF FAGHGVAVTI VTVGGACEAT PHLGIADAIV DLSSSGTTLR 

       190        200        210        220        230        240 
TNHLRVVDEV LASTTVLVAN PASLTAKREK IDEIILALES VIRAKGQCYL MMNVQRNALA 

       250        260        270        280        290        300 
DVREVLPGLS GPTVMDVASD ENLVAVHAVV KEERVYQLIN QLKRAGAKDI LVMPIERIIR

« Hide

References

[1]"Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1."
Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., Land M. expand/collapse author list , Lucas S., Richardson P., Whitman W., Kyrpides N.C.
Stand. Genomic Sci. 1:189-196(2009) [PubMed: 21304656] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35101 / DSM 1498 / JR1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000562 Genomic DNA. Translation: ABN56770.1.
RefSeqYP_001046752.1. NC_009051.1.

3D structure databases

ProteinModelPortalA3CTS0.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3CTS0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4847627.
GenomeReviewsGene locus Memar_0837 in contig CP000562_GR.
KEGGmem:Memar_0837.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG04876.
HOGENOMHBG391868.
OMAWVALEVI.
PhylomeDBA3CTS0.
ProtClustDBPRK00489.

Family and domain databases

HAMAPMF_00079. HisG_Long.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR020621. ATP_PRibTrfase_HisG_long.
IPR013115. HisG_C.
IPR011322. N-reg_PII-like_a/b.
IPR015867. N-reg_PII/ATP_PRibTrfase_C.
[Graphical view]
Gene3DG3DSA:3.30.70.120. PII_glnB. 1 hit.
KOK00765.
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
PF08029. HisG_C. 1 hit.
[Graphical view]
SUPFAMSSF54913. N-reg_PII-like_a/b. 1 hit.
TIGRFAMsTIGR00070. HisG. 1 hit.
TIGR03455. HisG_C-term. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA3CTS0_METMJ
AccessionPrimary (citable) accession number: A3CTS0
Entry history
Integrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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