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Protein

AMP phosphorylase

Gene

Memar_0551

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-549-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Memar_0551
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147271 – 507AMP phosphorylaseAdd BLAST507

Proteomic databases

PRIDEiA3CSY4

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0551

Structurei

3D structure databases

ProteinModelPortaliA3CSY4
SMRiA3CSY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A3CSY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTVKLLDI ENRGVLLHCT DARSMRVRDG DRVQIVDEAT GKTAQAHVDT
60 70 80 90 100
TGSLIEPGVI GVYRPVNATL AVDEGTPVEV RGAERPASLE HIKKKMDGGR
110 120 130 140 150
FTKDDTVDIV RDIVDDVLSP GEITAYVTAS YINGLDMDEV EYLTRATVET
160 170 180 190 200
GERLHFTRHP IVDKHSIGGV PGNKITLLIA PIIAASGLLI PKTSSRAITG
210 220 230 240 250
AGGTADLMEV LAPVSFPALE VQQMTEKVGG AIVWGGATNI APADDKIITY
260 270 280 290 300
EYPLRIDARG QMIASVMAKK FAVGADLVVI DIPVGRNTKI ATAQEGRKLA
310 320 330 340 350
REFIDLGERL GMRVECALSY GESLVGHTIG PNLEVREALA VLEGATEPNS
360 370 380 390 400
LIQKSLSLAG IALEMAGKAG PGQGARAAAD ILRSGKALEK MRQIIEIQGG
410 420 430 440 450
DPNVKAEDIV PGECRFDVNA PQDGYVIELN NSALVTLARL AGSPYDHGAG
460 470 480 490 500
LLVHAKKGTR VRKGDPIFTI YADREWRLER AIEVGRTLMP VLVEGMVLER

IPHERWV
Length:507
Mass (Da):54,481
Last modified:March 20, 2007 - v1
Checksum:iE68D40285499FDFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN56484.1
RefSeqiWP_011843394.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN56484; ABN56484; Memar_0551
GeneIDi4846965
KEGGimem:Memar_0551

Similar proteinsi

Entry informationi

Entry nameiAMPPA_METMJ
AccessioniPrimary (citable) accession number: A3CSY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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