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A3CSY4

- AMPPA_METMJ

UniProt

A3CSY4 - AMPPA_METMJ

Protein

AMP phosphorylase

Gene

Memar_0551

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691AMP; via amide nitrogenUniRule annotation
    Binding sitei204 – 2041AMP; via amide nitrogenUniRule annotation
    Active sitei257 – 2571Proton donorUniRule annotation
    Binding sitei265 – 2651AMPUniRule annotation
    Binding sitei289 – 2891AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 2006AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciMMAR368407:GH7L-563-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Memar_0551
    OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
    Taxonomic identifieri368407 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
    ProteomesiUP000002146: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507AMP phosphorylasePRO_0000314727Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi368407.Memar_0551.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CSY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiLEWAFDE.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CSY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLTVKLLDI ENRGVLLHCT DARSMRVRDG DRVQIVDEAT GKTAQAHVDT    50
    TGSLIEPGVI GVYRPVNATL AVDEGTPVEV RGAERPASLE HIKKKMDGGR 100
    FTKDDTVDIV RDIVDDVLSP GEITAYVTAS YINGLDMDEV EYLTRATVET 150
    GERLHFTRHP IVDKHSIGGV PGNKITLLIA PIIAASGLLI PKTSSRAITG 200
    AGGTADLMEV LAPVSFPALE VQQMTEKVGG AIVWGGATNI APADDKIITY 250
    EYPLRIDARG QMIASVMAKK FAVGADLVVI DIPVGRNTKI ATAQEGRKLA 300
    REFIDLGERL GMRVECALSY GESLVGHTIG PNLEVREALA VLEGATEPNS 350
    LIQKSLSLAG IALEMAGKAG PGQGARAAAD ILRSGKALEK MRQIIEIQGG 400
    DPNVKAEDIV PGECRFDVNA PQDGYVIELN NSALVTLARL AGSPYDHGAG 450
    LLVHAKKGTR VRKGDPIFTI YADREWRLER AIEVGRTLMP VLVEGMVLER 500
    IPHERWV 507
    Length:507
    Mass (Da):54,481
    Last modified:March 20, 2007 - v1
    Checksum:iE68D40285499FDFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000562 Genomic DNA. Translation: ABN56484.1.
    RefSeqiYP_001046466.1. NC_009051.1.

    Genome annotation databases

    EnsemblBacteriaiABN56484; ABN56484; Memar_0551.
    GeneIDi4846965.
    KEGGimem:Memar_0551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000562 Genomic DNA. Translation: ABN56484.1 .
    RefSeqi YP_001046466.1. NC_009051.1.

    3D structure databases

    ProteinModelPortali A3CSY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 368407.Memar_0551.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN56484 ; ABN56484 ; Memar_0551 .
    GeneIDi 4846965.
    KEGGi mem:Memar_0551.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi LEWAFDE.

    Enzyme and pathway databases

    BioCyci MMAR368407:GH7L-563-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35101 / DSM 1498 / JR1.

    Entry informationi

    Entry nameiAMPPA_METMJ
    AccessioniPrimary (citable) accession number: A3CSY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3