A3CSY4 (TYPH_METMJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Memar_0551

Organism

Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) [Complete proteome] [HAMAP]

Taxonomic identifier

368407 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus › Methanoculleus marisnigri

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314727

Sequences

	Sequence		Length	Mass (Da)
	A3CSY4 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: E68D40285499FDFC	FASTA	507	54,481
	10 20 30 40 50 60 MKLTVKLLDI ENRGVLLHCT DARSMRVRDG DRVQIVDEAT GKTAQAHVDT TGSLIEPGVI 70 80 90 100 110 120 GVYRPVNATL AVDEGTPVEV RGAERPASLE HIKKKMDGGR FTKDDTVDIV RDIVDDVLSP 130 140 150 160 170 180 GEITAYVTAS YINGLDMDEV EYLTRATVET GERLHFTRHP IVDKHSIGGV PGNKITLLIA 190 200 210 220 230 240 PIIAASGLLI PKTSSRAITG AGGTADLMEV LAPVSFPALE VQQMTEKVGG AIVWGGATNI 250 260 270 280 290 300 APADDKIITY EYPLRIDARG QMIASVMAKK FAVGADLVVI DIPVGRNTKI ATAQEGRKLA 310 320 330 340 350 360 REFIDLGERL GMRVECALSY GESLVGHTIG PNLEVREALA VLEGATEPNS LIQKSLSLAG 370 380 390 400 410 420 IALEMAGKAG PGQGARAAAD ILRSGKALEK MRQIIEIQGG DPNVKAEDIV PGECRFDVNA 430 440 450 460 470 480 PQDGYVIELN NSALVTLARL AGSPYDHGAG LLVHAKKGTR VRKGDPIFTI YADREWRLER 490 500 AIEVGRTLMP VLVEGMVLER IPHERWV

References

[1]

"Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1." Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., Land M. , Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:189-196(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35101 / DSM 1498 / JR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000562 Genomic DNA. Translation: ABN56484.1.
RefSeq	YP_001046466.1. NC_009051.1.
3D structure databases
ProteinModelPortal	A3CSY4.
ModBase	Search...
Protein-protein interaction databases
STRING	368407.Memar_0551.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN56484; ABN56484; Memar_0551.
GeneID	4846965.
KEGG	mem:Memar_0551.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MMAR368407:GH7L-563-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METMJ

Accession

Primary (citable) accession number: A3CSY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 20, 2007
Last modified:	May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program