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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA), Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR368407:GH7L-524-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Memar_0514
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Cobalt-precorrin-5B C(1)-methyltransferasePRO_1000046866Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0514.

Structurei

3D structure databases

ProteinModelPortaliA3CSU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04383. Archaea.
COG1903. LUCA.
HOGENOMiHOG000223551.
KOiK02188.
OMAiNDHESDI.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
SUPFAMiSSF111342. SSF111342. 1 hit.

Sequencei

Sequence statusi: Complete.

A3CSU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPVTDFEY PAAWVAACRS PDLLDDVRRG LAVLTASGTV LRRGFSTGTT
60 70 80 90 100
AAAACKAAIL SLACDTVREV DVTLPCGIAV RLAVDGYRGQ ASCRKDAGDY
110 120 130 140 150
TADVTGGLEF VAMAAPSLSG GVQFVPGEGI GSFARDTPRH RRGTPAISAP
160 170 180 190 200
ALDCIRRSID EAVEEADLSG TTVILTIPRG AEVAQKTLNP RVGVHGGISV
210 220 230 240 250
LGTTGFVEPW DDHMTEGVID RIARAPGAVV LTTGRLGLRY SRLLFPEHEA
260 270 280 290 300
ILVGNKLEEA LRAVEGDAVI CGLPGLILKF MNPDVLSGTG CVTVEELSAT
310 320 330
PLWEETVRRE LAAFRARYPR VRVVIVDRDG RIIGEPP
Length:337
Mass (Da):35,742
Last modified:March 20, 2007 - v1
Checksum:i2BE2EF86A7D5E1D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN56447.1.
RefSeqiWP_011843357.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN56447; ABN56447; Memar_0514.
GeneIDi4846013.
KEGGimem:Memar_0514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN56447.1.
RefSeqiWP_011843357.1. NC_009051.1.

3D structure databases

ProteinModelPortaliA3CSU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368407.Memar_0514.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN56447; ABN56447; Memar_0514.
GeneIDi4846013.
KEGGimem:Memar_0514.

Phylogenomic databases

eggNOGiarCOG04383. Archaea.
COG1903. LUCA.
HOGENOMiHOG000223551.
KOiK02188.
OMAiNDHESDI.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciMMAR368407:GH7L-524-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
SUPFAMiSSF111342. SSF111342. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35101 / DSM 1498 / JR1.

Entry informationi

Entry nameiCBID_METMJ
AccessioniPrimary (citable) accession number: A3CSU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: December 9, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.