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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. Cobyrinate a,c-diamide synthase (cbiA), Cobyrinate a,c-diamide synthase (cbiA)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR368407:G1G85-510-MONOMER
UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:Memar_0514
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000468661 – 337Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST337

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0514

Structurei

3D structure databases

ProteinModelPortaliA3CSU7
SMRiA3CSU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04383 Archaea
COG1903 LUCA
HOGENOMiHOG000223551
KOiK02188
OMAiNDHESDI
OrthoDBiPOG093Z05FA

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 2 hits
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit

Sequencei

Sequence statusi: Complete.

A3CSU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDPVTDFEY PAAWVAACRS PDLLDDVRRG LAVLTASGTV LRRGFSTGTT
60 70 80 90 100
AAAACKAAIL SLACDTVREV DVTLPCGIAV RLAVDGYRGQ ASCRKDAGDY
110 120 130 140 150
TADVTGGLEF VAMAAPSLSG GVQFVPGEGI GSFARDTPRH RRGTPAISAP
160 170 180 190 200
ALDCIRRSID EAVEEADLSG TTVILTIPRG AEVAQKTLNP RVGVHGGISV
210 220 230 240 250
LGTTGFVEPW DDHMTEGVID RIARAPGAVV LTTGRLGLRY SRLLFPEHEA
260 270 280 290 300
ILVGNKLEEA LRAVEGDAVI CGLPGLILKF MNPDVLSGTG CVTVEELSAT
310 320 330
PLWEETVRRE LAAFRARYPR VRVVIVDRDG RIIGEPP
Length:337
Mass (Da):35,742
Last modified:March 20, 2007 - v1
Checksum:i2BE2EF86A7D5E1D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN56447.1
RefSeqiWP_011843357.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN56447; ABN56447; Memar_0514
GeneIDi4846013
KEGGimem:Memar_0514

Similar proteinsi

Entry informationi

Entry nameiCBID_METMJ
AccessioniPrimary (citable) accession number: A3CSU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health