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A3CSQ6

- TF2B_METMJ

UniProt

A3CSQ6 - TF2B_METMJ

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Protein

Transcription initiation factor IIB

Gene
tfb, Memar_0473
Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB) By similarity.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Zinc By similarity
Metal bindingi44 – 441Zinc By similarity
Metal bindingi60 – 601Zinc By similarity
Metal bindingi63 – 631Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 6833TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR368407:GH7L-482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Short name:
TFIIB
Gene namesi
Name:tfb
Ordered Locus Names:Memar_0473
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
ProteomesiUP000002146: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Transcription initiation factor IIBUniRule annotationPRO_1000080110Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0473.

Structurei

3D structure databases

ProteinModelPortaliA3CSQ6.
SMRiA3CSQ6. Positions 38-82, 141-335.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati154 – 237841UniRule annotationAdd
BLAST
Repeati248 – 329822UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CSQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MAEVEKLKQL QLQREALKKR GEQKVKETEK KRTEESVQSV CPECGSRQLV    50
HDYERAELVC QNCGLVLDEE FIDRGPEWRA FDHDQRMKRS RVGAPMTFTI 100
HDKGLSTMID WRNRDSYGRA ISSKNRAQLY RLRKWQRRIR VSNATERNLA 150
FALSELDRMA SALGLPRNVR ETAAVVYRDA VDKNLIRGRS IEGVAAAALY 200
AACRQCSVPR TLDEIAEVSR VSRKEIGRTY RFISRELGLK LLPTSPIDYV 250
PRFCSGLNLK GEVQSRAVEI LRQAGERELT SGRGPTGVAA AAIYISSILG 300
GERRTQREVA EVAGVTEVTI RNRYKELAEK LDIEIIL 337
Length:337
Mass (Da):38,278
Last modified:March 20, 2007 - v1
Checksum:iC4B988E6D9A85617
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000562 Genomic DNA. Translation: ABN56406.1.
RefSeqiYP_001046388.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN56406; ABN56406; Memar_0473.
GeneIDi4847082.
KEGGimem:Memar_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000562 Genomic DNA. Translation: ABN56406.1 .
RefSeqi YP_001046388.1. NC_009051.1.

3D structure databases

ProteinModelPortali A3CSQ6.
SMRi A3CSQ6. Positions 38-82, 141-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368407.Memar_0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN56406 ; ABN56406 ; Memar_0473 .
GeneIDi 4847082.
KEGGi mem:Memar_0473.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MMAR368407:GH7L-482-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35101 / DSM 1498 / JR1.

Entry informationi

Entry nameiTF2B_METMJ
AccessioniPrimary (citable) accession number: A3CSQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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