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A3CSQ6

- TF2B_METMJ

UniProt

A3CSQ6 - TF2B_METMJ

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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411ZincUniRule annotation
Metal bindingi44 – 441ZincUniRule annotation
Metal bindingi60 – 601ZincUniRule annotation
Metal bindingi63 – 631ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 6833TFIIB-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMMAR368407:GH7L-482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Memar_0473
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
ProteomesiUP000002146: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Transcription initiation factor IIBPRO_1000080110Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0473.

Structurei

3D structure databases

ProteinModelPortaliA3CSQ6.
SMRiA3CSQ6. Positions 38-82, 141-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati154 – 237841Add
BLAST
Repeati248 – 329822Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation
Contains 1 TFIIB-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 6833TFIIB-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108633.
KOiK03124.
OMAiWRAFDHD.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CSQ6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEVEKLKQL QLQREALKKR GEQKVKETEK KRTEESVQSV CPECGSRQLV
60 70 80 90 100
HDYERAELVC QNCGLVLDEE FIDRGPEWRA FDHDQRMKRS RVGAPMTFTI
110 120 130 140 150
HDKGLSTMID WRNRDSYGRA ISSKNRAQLY RLRKWQRRIR VSNATERNLA
160 170 180 190 200
FALSELDRMA SALGLPRNVR ETAAVVYRDA VDKNLIRGRS IEGVAAAALY
210 220 230 240 250
AACRQCSVPR TLDEIAEVSR VSRKEIGRTY RFISRELGLK LLPTSPIDYV
260 270 280 290 300
PRFCSGLNLK GEVQSRAVEI LRQAGERELT SGRGPTGVAA AAIYISSILG
310 320 330
GERRTQREVA EVAGVTEVTI RNRYKELAEK LDIEIIL
Length:337
Mass (Da):38,278
Last modified:March 20, 2007 - v1
Checksum:iC4B988E6D9A85617
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000562 Genomic DNA. Translation: ABN56406.1.
RefSeqiWP_011843316.1. NC_009051.1.
YP_001046388.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN56406; ABN56406; Memar_0473.
GeneIDi4847082.
KEGGimem:Memar_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000562 Genomic DNA. Translation: ABN56406.1 .
RefSeqi WP_011843316.1. NC_009051.1.
YP_001046388.1. NC_009051.1.

3D structure databases

ProteinModelPortali A3CSQ6.
SMRi A3CSQ6. Positions 38-82, 141-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 368407.Memar_0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN56406 ; ABN56406 ; Memar_0473 .
GeneIDi 4847082.
KEGGi mem:Memar_0473.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108633.
KOi K03124.
OMAi WRAFDHD.

Enzyme and pathway databases

BioCyci MMAR368407:GH7L-482-MONOMER.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
HAMAPi MF_00383. TF2B_arch.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35101 / DSM 1498 / JR1.

Entry informationi

Entry nameiTF2B_METMJ
AccessioniPrimary (citable) accession number: A3CSQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3