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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41ZincUniRule annotation1
Metal bindingi44ZincUniRule annotation1
Metal bindingi60ZincUniRule annotation1
Metal bindingi63ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 68TFIIB-typeUniRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Memar_0473
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000801101 – 337Transcription initiation factor IIBAdd BLAST337

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi368407.Memar_0473

Structurei

3D structure databases

ProteinModelPortaliA3CSQ6
SMRiA3CSQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 2371Add BLAST84
Repeati248 – 3292Add BLAST82

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 68TFIIB-typeUniRule annotationAdd BLAST33

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiarCOG01981 Archaea
COG1405 LUCA
HOGENOMiHOG000108633
KOiK03124
OMAiWRAFDHD
OrthoDBiPOG093Z07LX

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
HAMAPiMF_00383 TF2B_arch, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR000812 TFIIB
IPR023484 TFIIB_arc
IPR023486 TFIIB_CS
IPR013150 TFIIB_cyclin
IPR013137 Znf_TFIIB
PANTHERiPTHR11618 PTHR11618, 1 hit
PfamiView protein in Pfam
PF08271 TF_Zn_Ribbon, 1 hit
PF00382 TFIIB, 2 hits
PRINTSiPR00685 TIFACTORIIB
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00782 TFIIB, 2 hits
PS51134 ZF_TFIIB, 1 hit

Sequencei

Sequence statusi: Complete.

A3CSQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVEKLKQL QLQREALKKR GEQKVKETEK KRTEESVQSV CPECGSRQLV
60 70 80 90 100
HDYERAELVC QNCGLVLDEE FIDRGPEWRA FDHDQRMKRS RVGAPMTFTI
110 120 130 140 150
HDKGLSTMID WRNRDSYGRA ISSKNRAQLY RLRKWQRRIR VSNATERNLA
160 170 180 190 200
FALSELDRMA SALGLPRNVR ETAAVVYRDA VDKNLIRGRS IEGVAAAALY
210 220 230 240 250
AACRQCSVPR TLDEIAEVSR VSRKEIGRTY RFISRELGLK LLPTSPIDYV
260 270 280 290 300
PRFCSGLNLK GEVQSRAVEI LRQAGERELT SGRGPTGVAA AAIYISSILG
310 320 330
GERRTQREVA EVAGVTEVTI RNRYKELAEK LDIEIIL
Length:337
Mass (Da):38,278
Last modified:March 20, 2007 - v1
Checksum:iC4B988E6D9A85617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA Translation: ABN56406.1
RefSeqiWP_011843316.1, NC_009051.1

Genome annotation databases

EnsemblBacteriaiABN56406; ABN56406; Memar_0473
GeneIDi4847082
KEGGimem:Memar_0473

Similar proteinsi

Entry informationi

Entry nameiTF2B_METMJ
AccessioniPrimary (citable) accession number: A3CSQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health