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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41ZincUniRule annotation1
Metal bindingi44ZincUniRule annotation1
Metal bindingi60ZincUniRule annotation1
Metal bindingi63ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 68TFIIB-typeUniRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:Memar_0473
OrganismiMethanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)
Taxonomic identifieri368407 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000002146 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000801101 – 337Transcription initiation factor IIBAdd BLAST337

Interactioni

Protein-protein interaction databases

STRINGi368407.Memar_0473.

Structurei

3D structure databases

ProteinModelPortaliA3CSQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 2371Add BLAST84
Repeati248 – 3292Add BLAST82

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation
Contains 1 TFIIB-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 68TFIIB-typeUniRule annotationAdd BLAST33

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiarCOG01981. Archaea.
COG1405. LUCA.
HOGENOMiHOG000108633.
KOiK03124.
OMAiHDYERAE.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CSQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVEKLKQL QLQREALKKR GEQKVKETEK KRTEESVQSV CPECGSRQLV
60 70 80 90 100
HDYERAELVC QNCGLVLDEE FIDRGPEWRA FDHDQRMKRS RVGAPMTFTI
110 120 130 140 150
HDKGLSTMID WRNRDSYGRA ISSKNRAQLY RLRKWQRRIR VSNATERNLA
160 170 180 190 200
FALSELDRMA SALGLPRNVR ETAAVVYRDA VDKNLIRGRS IEGVAAAALY
210 220 230 240 250
AACRQCSVPR TLDEIAEVSR VSRKEIGRTY RFISRELGLK LLPTSPIDYV
260 270 280 290 300
PRFCSGLNLK GEVQSRAVEI LRQAGERELT SGRGPTGVAA AAIYISSILG
310 320 330
GERRTQREVA EVAGVTEVTI RNRYKELAEK LDIEIIL
Length:337
Mass (Da):38,278
Last modified:March 20, 2007 - v1
Checksum:iC4B988E6D9A85617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN56406.1.
RefSeqiWP_011843316.1. NC_009051.1.

Genome annotation databases

EnsemblBacteriaiABN56406; ABN56406; Memar_0473.
GeneIDi4847082.
KEGGimem:Memar_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000562 Genomic DNA. Translation: ABN56406.1.
RefSeqiWP_011843316.1. NC_009051.1.

3D structure databases

ProteinModelPortaliA3CSQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi368407.Memar_0473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN56406; ABN56406; Memar_0473.
GeneIDi4847082.
KEGGimem:Memar_0473.

Phylogenomic databases

eggNOGiarCOG01981. Archaea.
COG1405. LUCA.
HOGENOMiHOG000108633.
KOiK03124.
OMAiHDYERAE.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
HAMAPiMF_00383. TF2B_arch. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023484. TFIIB_arc.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF2B_METMJ
AccessioniPrimary (citable) accession number: A3CSQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.