A3CRT6 (ARGC_METMJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	Memar_0151

Organism

Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) [Complete proteome] [HAMAP]

Taxonomic identifier

368407 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanomicrobiales › Methanomicrobiaceae › Methanoculleus

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000011014
Sites
	Active site	143	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3CRT6 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 1718F288CE46E85E	FASTA	328	35,305
	10 20 30 40 50 60 MEIAIIGASG YTGGELMRLL LHHPSADVVA ATSRKLDGTP VASVHPHLRG LTDLVFRNAG 70 80 90 100 110 120 AGDIDADFAF LAVPHTAAMK VAGTLAERGI RTVDLSADYR LPKDVYEKIY GVTHEAYFEA 130 140 150 160 170 180 PYGLPELHRD EIRGASFVAN PGCFPTGATL AAAPLAKFAH TIIYDSKTGV SGAGTSPSAT 190 200 210 220 230 240 THYPNVGDNF SAYKWTSHRH LAEMKQEAAR LGSTARCYFT PHLLPVNRGI LTTAHILLRE 250 260 270 280 290 300 PMGQDEVEAL YKKFYADEFF VRYQKPTLAA VRGTNFCDVA VESEGDRVVA VSAIDNLVKG 310 320 ASGQAIQNMN LMCGFAEDTG LRTAGMFP

References

[1]

"Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981 type strain JR1." Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C., Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L., Land M. , Lucas S., Richardson P., Whitman W.B., Kyrpides N.C. Stand. Genomic Sci. 1:189-196(2009) [PubMed: 21304656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35101 / DSM 1498 / JR1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000562 Genomic DNA. Translation: ABN56086.1.
RefSeq	YP_001046068.1. NC_009051.1.
3D structure databases
ProteinModelPortal	A3CRT6.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CRT6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4846168.
GenomeReviews	Gene locus Memar_0151 in contig CP000562_GR.
KEGG	mem:Memar_0151.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05044.
HOGENOM	HBG294213.
OMA	VCRIAVH.
PhylomeDB	A3CRT6.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	MMAR368407:MEMAR_0151-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_METMJ

Accession

Primary (citable) accession number: A3CRT6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 20, 2007
Last modified:	November 16, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program