Skip Header

Contribute Send feedback
Read comments (?) or add your own

A3CQT4 (DAPEL_STRSV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47
Gene names
Ordered Locus Names:SSA_2173
OrganismStreptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]
Taxonomic identifier388919 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692

Catalytic activity

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692

Sequence similarities

Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692
PRO_0000376789

Sites

Active site691 By similarity
Active site1281Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A3CQT4 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 33AB98D4FDC327C9

FASTA37741,864
        10         20         30         40         50         60 
MLDYLNIRRD LHQIPEIGLE EYKTHAYLMQ VIDGLTAGLD FVEIRTWRTG ILVFIKGSSP 

        70         80         90        100        110        120 
DKTIGWRTDI DGLPIVEDTG LDFASTHEGR MHACGHDMHM TVALGLLEQA VSTQPTHNLL 

       130        140        150        160        170        180 
FLFQPAEENE AGGMLMYEDG AFGDWLPDEF YGLHVRPDLK VGDIATNRGT LFAGTCEVKL 

       190        200        210        220        230        240 
TFKGKGGHAA FPHEANDALV AASYFITQVQ TIVSRNVDPI EGAVVTFGSL HAGTTNNVIA 

       250        260        270        280        290        300 
ETAFLHGTIR TLTQEMNLLT QKRLREIAEG LAQSFGLELD LELKQGGYLP VENHPDLADE 

       310        320        330        340        350        360 
LMDFFQKEEG VQLIDIEPAM TGEDFGYLLS KVKGVMFWLG VDSPYALHHP KMTPDEAALP 

       370 
FAIEKIGKFL DYKINER

« Hide

References

[1]"Genome of the opportunistic pathogen Streptococcus sanguinis."
Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A.
J. Bacteriol. 189:3166-3175(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SK36.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000387 Genomic DNA. Translation: ABN45539.1.
RefSeqYP_001036089.1. NC_009009.1.

3D structure databases

ProteinModelPortalA3CQT4.
ModBaseSearch...

Protein-protein interaction databases

STRING388919.SSA_2173.

Protein family/group databases

MEROPSM20.A27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN45539; ABN45539; SSA_2173.
GeneID4806562.
KEGGssa:SSA_2173.
PATRIC19771249. VBIStrSan33173_2058.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1473.
HOGENOMHOG000241404.
KOK05823.
OMAASQHEGR.
ProtClustDBCLSK876719.

Enzyme and pathway databases

UniPathwayUPA00034; UER00024.

Family and domain databases

HAMAPMF_01692. DapEL.
InterProIPR023905. AcetylDAP_deacetylase.
IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01891. amidohydrolases. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. False negative.
PS00759. ARGE_DAPE_CPG2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPEL_STRSV
AccessionPrimary (citable) accession number: A3CQT4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 20, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents