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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSSAN388919:SSA_1959-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA
Ordered Locus Names:SSA_1959
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002148 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei45 – 65HelicalUniRule annotationAdd BLAST21
Transmembranei86 – 106HelicalUniRule annotationAdd BLAST21
Transmembranei114 – 134HelicalUniRule annotationAdd BLAST21
Transmembranei147 – 167HelicalUniRule annotationAdd BLAST21
Transmembranei188 – 208HelicalUniRule annotationAdd BLAST21
Transmembranei223 – 243HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002907731 – 280Undecaprenyl-diphosphataseAdd BLAST280

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_1959

Structurei

3D structure databases

SMRiA3CQ79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiPDARMGW

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit

Sequencei

Sequence statusi: Complete.

A3CQ79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIIEIFISI IYGIIEGITE WLPISSTGHL ILIQDFIQFK NQSPAFMEMF
60 70 80 90 100
NVVIQLGAIL AVVVIYFDKL NPFKPGKSAR QVQKTWQLWA KVVVAALPAA
110 120 130 140 150
VIGLFLDDWF EAHFYNLVSV SVMLIVYGAA FIYLERREHE EPAVTDLASL
160 170 180 190 200
PYKTALQIGL FQILALFPGT SRSGATIVGG LLNGVSRSVV TEFTFYLGIP
210 220 230 240 250
IMFGASGWKI LKFIKNGNGL GFGQIFLLLV AMGVAFGVSL VVIRFLTDYV
260 270 280
KKHDFTIFGK YRIGLGGVLL VYAAIKALMG
Length:280
Mass (Da):30,944
Last modified:March 20, 2007 - v1
Checksum:i8DAFFA292C0C4512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA Translation: ABN45334.1
RefSeqiWP_011837466.1, NC_009009.1
YP_001035884.1, NC_009009.1

Genome annotation databases

EnsemblBacteriaiABN45334; ABN45334; SSA_1959
GeneIDi4807023
KEGGissa:SSA_1959
PATRICifig|388919.9.peg.1858

Similar proteinsi

Entry informationi

Entry nameiUPPP_STRSV
AccessioniPrimary (citable) accession number: A3CQ79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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