SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A3CPX9

- LUXS_STRSV

UniProt

A3CPX9 - LUXS_STRSV

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

S-ribosylhomocysteine lyase

Gene
luxS, SSA_1853
Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron By similarity
Metal bindingi61 – 611Iron By similarity
Metal bindingi127 – 1271Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSSAN388919:GHEN-1827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:SSA_1853
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160S-ribosylhomocysteine lyaseUniRule annotationPRO_0000298048Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi388919.SSA_1853.

Structurei

3D structure databases

ProteinModelPortaliA3CPX9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

eggNOGiCOG1854.
HOGENOMiHOG000040372.
KOiK07173.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

A3CPX9-1 [UniParc]FASTAAdd to Basket

« Hide

MSKEVVVESF ELDHTIVKAP YVRLIGEETG PKGDIISNFD IRLVQPNEDS    50
IPTAGLHTIE HLLAMLIRKR IDGMIDCSPF GCRTGFHMIM WGQHSSSQIA 100
QVIKSCLEEI AESTSWEDVP GTTIESCGNY KDHSLFSAKE WAKLILSQGI 150
SDDAFERHVI 160
Length:160
Mass (Da):17,873
Last modified:August 21, 2007 - v2
Checksum:i3D1891BD485511BB
GO

Sequence cautioni

The sequence ABN45234.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN45234.1. Different initiation.
RefSeqiYP_001035784.1. NC_009009.1.

Genome annotation databases

EnsemblBacteriaiABN45234; ABN45234; SSA_1853.
GeneIDi4807415.
KEGGissa:SSA_1853.
PATRICi19770633. VBIStrSan33173_1758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN45234.1 . Different initiation.
RefSeqi YP_001035784.1. NC_009009.1.

3D structure databases

ProteinModelPortali A3CPX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388919.SSA_1853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN45234 ; ABN45234 ; SSA_1853 .
GeneIDi 4807415.
KEGGi ssa:SSA_1853.
PATRICi 19770633. VBIStrSan33173_1758.

Phylogenomic databases

eggNOGi COG1854.
HOGENOMi HOG000040372.
KOi K07173.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci SSAN388919:GHEN-1827-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK36.

Entry informationi

Entry nameiLUXS_STRSV
AccessioniPrimary (citable) accession number: A3CPX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi