A3CNS8 (HIS2_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	SSA_1440

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_0000319667

Sequences

	Sequence		Length	Mass (Da)
	A3CNS8 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 17914109C9AC3BC6	FASTA	104	11,807
	10 20 30 40 50 60 MLETLYQEAL KRKKEPKEGS YTSYLYDKGL DKILKKVGEE ATEVVIAAKN ADKNEMANET 70 80 90 100 ADLLYHLAVA LVETGVSLEE VETVLQARQG KQSRIHDRPE IDHY

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed: 17277061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN44833.1.
RefSeq	YP_001035383.1. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CNS8.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CNS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000050829; EBSTRP00000047093; EBSTRG00000050821.
GeneID	4807559.
GenomeReviews	Gene locus SSA_1440 in contig CP000387_GR.
KEGG	ssa:SSA_1440.
NMPDR	fig|388919.8.peg.1276.
PATRIC	19769816. VBIStrSan33173_1365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0140.
GeneTree	EBGT00050000029424.
HOGENOM	HBG646527.
OMA	EMRRREN.
ProtClustDB	PRK00400.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_STRSV

Accession

Primary (citable) accession number: A3CNS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 20, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program