A3CNI7 (PYRB_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	SSA_1343

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321168

Sequences

	Sequence		Length	Mass (Da)
	A3CNI7 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 1618CFEBBDFCFC7E	FASTA	305	34,672
	10 20 30 40 50 60 MSSNQIALKN LVSMETLSNE EVMALIKRGI EFKNGAKVHY DEQHIVSNLF FEPSTRTHKA 70 80 90 100 110 120 FEVAELKLGC DLLDFDVKTS SVNKGETLYD TILTMSALGV DVCVIRHPEV DYYKELVESP 130 140 150 160 170 180 TITTSIVNGG DGSGQHPSQS LLDLMTIYQE FGRFEGLKVA IAGDLDHSRV AKSNMQILKR 190 200 210 220 230 240 LGAELYFAGP EEWRSQEFAD YGKFVTIDEV IEEVDVMMFL RVQHERHDYE SIFSKENYHR 250 260 270 280 290 300 LHGLTQERYD RMKDTAILMH PAPVNRDVEI ADHLVEAPKS RIVEQMTNGV FVRMAIIEAV LKGRQ

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed: 17277061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN44742.1.
RefSeq	YP_001035292.1. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CNI7.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CNI7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000052789; EBSTRP00000049053; EBSTRG00000052779.
GeneID	4807482.
GenomeReviews	Gene locus SSA_1343 in contig CP000387_GR.
KEGG	ssa:SSA_1343.
NMPDR	fig|388919.8.peg.1196.
PATRIC	19769640. VBIStrSan33173_1277.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000027081.
HOGENOM	HBG579429.
OMA	DLYTIRQ.
PhylomeDB	A3CNI7.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STRSV

Accession

Primary (citable) accession number: A3CNI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 20, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program