Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 2UniRule annotation
Short name:
FHS 2UniRule annotation
Short name:
FTHFS 2UniRule annotation
Gene namesi
Name:fhs2UniRule annotation
Ordered Locus Names:SSA_1200
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002148 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002930701 – 556Formate--tetrahydrofolate ligase 2Add BLAST556

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_1200.

Structurei

3D structure databases

ProteinModelPortaliA3CN49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLEVMNET.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CN49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQS VELQPIVDVV KKVGIDYDDL ELYGKYKAKL SFDKIREVEK
60 70 80 90 100
NPVGKLILVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP
110 120 130 140 150
VMGIKGGAAG GGHAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ
160 170 180 190 200
GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGSPVNGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DIEDLKKRLA NIVIGYRYDR TPVYVRDLEV EGALALVLKD
260 270 280 290 300
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV
360 370 380 390 400
EAVRAGFANL KRHVENIRKF GIPAVVAINE FVSDTEAEVA TLKELCAEIG
410 420 430 440 450
VPVELASVWA DGAEGGVTLA ETVVKTIAEE PAHYTRLYDN DLSIEEKIEK
460 470 480 490 500
IVTEIYRGSK VNFEKKAQTQ IREIVKNSWD KLPICMAKTQ YSFSDNPASL
510 520 530 540 550
GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA ALNMDVAADG

TAIGLF
Length:556
Mass (Da):59,798
Last modified:March 20, 2007 - v1
Checksum:iC47B78DCDE35E915
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA. Translation: ABN44604.1.
RefSeqiWP_011836985.1. NC_009009.1.
YP_001035154.1. NC_009009.1.

Genome annotation databases

EnsemblBacteriaiABN44604; ABN44604; SSA_1200.
GeneIDi4807947.
KEGGissa:SSA_1200.
PATRICi19769360. VBIStrSan33173_1141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA. Translation: ABN44604.1.
RefSeqiWP_011836985.1. NC_009009.1.
YP_001035154.1. NC_009009.1.

3D structure databases

ProteinModelPortaliA3CN49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi388919.SSA_1200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN44604; ABN44604; SSA_1200.
GeneIDi4807947.
KEGGissa:SSA_1200.
PATRICi19769360. VBIStrSan33173_1141.

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLEVMNET.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTHS2_STRSV
AccessioniPrimary (citable) accession number: A3CN49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.