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A3CN49

- FTHS2_STRSV

UniProt

A3CN49 - FTHS2_STRSV

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Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAN388919:GHEN-1177-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 2UniRule annotation
Short name:
FHS 2UniRule annotation
Short name:
FTHFS 2UniRule annotation
Gene namesi
Name:fhs2UniRule annotation
Ordered Locus Names:SSA_1200
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligase 2PRO_0000293070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_1200.

Structurei

3D structure databases

ProteinModelPortaliA3CN49.
SMRiA3CN49. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CN49-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQS VELQPIVDVV KKVGIDYDDL ELYGKYKAKL SFDKIREVEK
60 70 80 90 100
NPVGKLILVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP
110 120 130 140 150
VMGIKGGAAG GGHAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ
160 170 180 190 200
GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGSPVNGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT DIEDLKKRLA NIVIGYRYDR TPVYVRDLEV EGALALVLKD
260 270 280 290 300
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG
310 320 330 340 350
FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV
360 370 380 390 400
EAVRAGFANL KRHVENIRKF GIPAVVAINE FVSDTEAEVA TLKELCAEIG
410 420 430 440 450
VPVELASVWA DGAEGGVTLA ETVVKTIAEE PAHYTRLYDN DLSIEEKIEK
460 470 480 490 500
IVTEIYRGSK VNFEKKAQTQ IREIVKNSWD KLPICMAKTQ YSFSDNPASL
510 520 530 540 550
GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA ALNMDVAADG

TAIGLF
Length:556
Mass (Da):59,798
Last modified:March 20, 2007 - v1
Checksum:iC47B78DCDE35E915
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN44604.1.
RefSeqiWP_011836985.1. NC_009009.1.
YP_001035154.1. NC_009009.1.

Genome annotation databases

EnsemblBacteriaiABN44604; ABN44604; SSA_1200.
GeneIDi4807947.
KEGGissa:SSA_1200.
PATRICi19769360. VBIStrSan33173_1141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN44604.1 .
RefSeqi WP_011836985.1. NC_009009.1.
YP_001035154.1. NC_009009.1.

3D structure databases

ProteinModelPortali A3CN49.
SMRi A3CN49. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388919.SSA_1200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN44604 ; ABN44604 ; SSA_1200 .
GeneIDi 4807947.
KEGGi ssa:SSA_1200.
PATRICi 19769360. VBIStrSan33173_1141.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSAN388919:GHEN-1177-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK36.

Entry informationi

Entry nameiFTHS2_STRSV
AccessioniPrimary (citable) accession number: A3CN49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3