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A3CN49

- FTHS2_STRSV

UniProt

A3CN49 - FTHS2_STRSV

Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSAN388919:GHEN-1177-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 2UniRule annotation
    Short name:
    FHS 2UniRule annotation
    Short name:
    FTHFS 2UniRule annotation
    Gene namesi
    Name:fhs2UniRule annotation
    Ordered Locus Names:SSA_1200
    OrganismiStreptococcus sanguinis (strain SK36)
    Taxonomic identifieri388919 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002148: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligase 2PRO_0000293070Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi388919.SSA_1200.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CN49.
    SMRiA3CN49. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIPRESGF.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CN49-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQS VELQPIVDVV KKVGIDYDDL ELYGKYKAKL SFDKIREVEK    50
    NPVGKLILVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP 100
    VMGIKGGAAG GGHAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ 150
    GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGSPVNGIPR EDGFDITVAS 200
    EIMAILCLAT DIEDLKKRLA NIVIGYRYDR TPVYVRDLEV EGALALVLKD 250
    AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 300
    FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV 350
    EAVRAGFANL KRHVENIRKF GIPAVVAINE FVSDTEAEVA TLKELCAEIG 400
    VPVELASVWA DGAEGGVTLA ETVVKTIAEE PAHYTRLYDN DLSIEEKIEK 450
    IVTEIYRGSK VNFEKKAQTQ IREIVKNSWD KLPICMAKTQ YSFSDNPASL 500
    GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA ALNMDVAADG 550
    TAIGLF 556
    Length:556
    Mass (Da):59,798
    Last modified:March 20, 2007 - v1
    Checksum:iC47B78DCDE35E915
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000387 Genomic DNA. Translation: ABN44604.1.
    RefSeqiYP_001035154.1. NC_009009.1.

    Genome annotation databases

    EnsemblBacteriaiABN44604; ABN44604; SSA_1200.
    GeneIDi4807947.
    KEGGissa:SSA_1200.
    PATRICi19769360. VBIStrSan33173_1141.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000387 Genomic DNA. Translation: ABN44604.1 .
    RefSeqi YP_001035154.1. NC_009009.1.

    3D structure databases

    ProteinModelPortali A3CN49.
    SMRi A3CN49. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 388919.SSA_1200.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN44604 ; ABN44604 ; SSA_1200 .
    GeneIDi 4807947.
    KEGGi ssa:SSA_1200.
    PATRICi 19769360. VBIStrSan33173_1141.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IPRESGF.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSAN388919:GHEN-1177-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK36.

    Entry informationi

    Entry nameiFTHS2_STRSV
    AccessioniPrimary (citable) accession number: A3CN49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3