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A3CN49 (FTHS2_STRSV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase 2

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name=FHS 2
Short name=FTHFS 2
Gene names
Name:fhs2
Ordered Locus Names:SSA_1200
OrganismStreptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]
Taxonomic identifier388919 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase 2 HAMAP-Rule MF_01543
PRO_0000293070

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A3CN49 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: C47B78DCDE35E915

FASTA55659,798
        10         20         30         40         50         60 
MKTDIEIAQS VELQPIVDVV KKVGIDYDDL ELYGKYKAKL SFDKIREVEK NPVGKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP VMGIKGGAAG GGHAQVLPME 

       130        140        150        160        170        180 
DINLHFTGDM HAITTANNAL SALIDNHLHQ GNALGIDQRR IIWKRVVDLN DRALRHVTVG 

       190        200        210        220        230        240 
LGSPVNGIPR EDGFDITVAS EIMAILCLAT DIEDLKKRLA NIVIGYRYDR TPVYVRDLEV 

       250        260        270        280        290        300 
EGALALVLKD AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV EAVRAGFANL 

       370        380        390        400        410        420 
KRHVENIRKF GIPAVVAINE FVSDTEAEVA TLKELCAEIG VPVELASVWA DGAEGGVTLA 

       430        440        450        460        470        480 
ETVVKTIAEE PAHYTRLYDN DLSIEEKIEK IVTEIYRGSK VNFEKKAQTQ IREIVKNSWD 

       490        500        510        520        530        540 
KLPICMAKTQ YSFSDNPASL GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA 

       550 
ALNMDVAADG TAIGLF 

« Hide

References

[1]"Genome of the opportunistic pathogen Streptococcus sanguinis."
Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A.
J. Bacteriol. 189:3166-3175(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SK36.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000387 Genomic DNA. Translation: ABN44604.1.
RefSeqYP_001035154.1. NC_009009.1.

3D structure databases

ProteinModelPortalA3CN49.
SMRA3CN49. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING388919.SSA_1200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN44604; ABN44604; SSA_1200.
GeneID4807947.
KEGGssa:SSA_1200.
PATRIC19769360. VBIStrSan33173_1141.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIPRESGF.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycSSAN388919:GHEN-1177-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS2_STRSV
AccessionPrimary (citable) accession number: A3CN49
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways