A3CN49 (FTHS2_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 2
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name=FHS 2
Short name=FTHFS 2

Gene names

Name:	fhs2
Ordered Locus Names:	SSA_1200

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Formate--tetrahydrofolate ligase 2 HAMAP MF_01543		PRO_0000293070
Regions
	Nucleotide binding	65 – 72	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3CN49 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: C47B78DCDE35E915	FASTA	556	59,798
	10 20 30 40 50 60 MKTDIEIAQS VELQPIVDVV KKVGIDYDDL ELYGKYKAKL SFDKIREVEK NPVGKLILVT 70 80 90 100 110 120 AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP VMGIKGGAAG GGHAQVLPME 130 140 150 160 170 180 DINLHFTGDM HAITTANNAL SALIDNHLHQ GNALGIDQRR IIWKRVVDLN DRALRHVTVG 190 200 210 220 230 240 LGSPVNGIPR EDGFDITVAS EIMAILCLAT DIEDLKKRLA NIVIGYRYDR TPVYVRDLEV 250 260 270 280 290 300 EGALALVLKD AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 310 320 330 340 350 360 FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV EAVRAGFANL 370 380 390 400 410 420 KRHVENIRKF GIPAVVAINE FVSDTEAEVA TLKELCAEIG VPVELASVWA DGAEGGVTLA 430 440 450 460 470 480 ETVVKTIAEE PAHYTRLYDN DLSIEEKIEK IVTEIYRGSK VNFEKKAQTQ IREIVKNSWD 490 500 510 520 530 540 KLPICMAKTQ YSFSDNPASL GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA 550 ALNMDVAADG TAIGLF

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed: 17277061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN44604.1.
RefSeq	YP_001035154.1. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CN49.
SMR	A3CN49. Positions 4-554.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CN49.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000052571; EBSTRP00000048835; EBSTRG00000052561.
GeneID	4807947.
GenomeReviews	Gene locus SSA_1200 in contig CP000387_GR.
KEGG	ssa:SSA_1200.
NMPDR	fig|388919.8.peg.1075.
PATRIC	19769360. VBIStrSan33173_1141.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
GeneTree	EBGT00050000027107.
HOGENOM	HBG677721.
OMA	LEWHINN.
PhylomeDB	A3CN49.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS2_STRSV

Accession

Primary (citable) accession number: A3CN49

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	March 20, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program