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A3CN49

- FTHS2_STRSV

UniProt

A3CN49 - FTHS2_STRSV

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Protein

Formate--tetrahydrofolate ligase 2

Gene
fhs2, SSA_1200
Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAN388919:GHEN-1177-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name:
FHS 2
Short name:
FTHFS 2
Gene namesi
Name:fhs2
Ordered Locus Names:SSA_1200
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligase 2UniRule annotationPRO_0000293070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_1200.

Structurei

3D structure databases

ProteinModelPortaliA3CN49.
SMRiA3CN49. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CN49-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQS VELQPIVDVV KKVGIDYDDL ELYGKYKAKL SFDKIREVEK    50
NPVGKLILVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP 100
VMGIKGGAAG GGHAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ 150
GNALGIDQRR IIWKRVVDLN DRALRHVTVG LGSPVNGIPR EDGFDITVAS 200
EIMAILCLAT DIEDLKKRLA NIVIGYRYDR TPVYVRDLEV EGALALVLKD 250
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTVTEAG 300
FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV 350
EAVRAGFANL KRHVENIRKF GIPAVVAINE FVSDTEAEVA TLKELCAEIG 400
VPVELASVWA DGAEGGVTLA ETVVKTIAEE PAHYTRLYDN DLSIEEKIEK 450
IVTEIYRGSK VNFEKKAQTQ IREIVKNSWD KLPICMAKTQ YSFSDNPASL 500
GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA ALNMDVAADG 550
TAIGLF 556
Length:556
Mass (Da):59,798
Last modified:March 20, 2007 - v1
Checksum:iC47B78DCDE35E915
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN44604.1.
RefSeqiYP_001035154.1. NC_009009.1.

Genome annotation databases

EnsemblBacteriaiABN44604; ABN44604; SSA_1200.
GeneIDi4807947.
KEGGissa:SSA_1200.
PATRICi19769360. VBIStrSan33173_1141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN44604.1 .
RefSeqi YP_001035154.1. NC_009009.1.

3D structure databases

ProteinModelPortali A3CN49.
SMRi A3CN49. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388919.SSA_1200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN44604 ; ABN44604 ; SSA_1200 .
GeneIDi 4807947.
KEGGi ssa:SSA_1200.
PATRICi 19769360. VBIStrSan33173_1141.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSAN388919:GHEN-1177-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK36.

Entry informationi

Entry nameiFTHS2_STRSV
AccessioniPrimary (citable) accession number: A3CN49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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