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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciSSAN388919:G1G6Q-1160-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:SSA_1182
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002148 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000639381 – 444Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST444

Proteomic databases

PRIDEiA3CN32

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_1182

Structurei

3D structure databases

ProteinModelPortaliA3CN32
SMRiA3CN32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3CN32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSYINVIG AGLAGSEAAY QIAKRGIPVK LYEMRGVKST PQHKTADFAE
60 70 80 90 100
LVCSNSLRGD ALTNAVGLLK EEMRRLDSVI LKSAEATRVP AGGALAVDRE
110 120 130 140 150
GFSQMVTELV TNHPLIEVIR EEITEIPEDA ITVIATGPLT SDALAEKIHA
160 170 180 190 200
LNGGDGFYFY DAAAPIIDVN TIDMTKVYLK SRYDKGEAAY LNAPMTKQEF
210 220 230 240 250
MDFHDALVNA EEAPLNSFEK EKYFEGCMPI EVMAKRGIKT MLYGPMKPVG
260 270 280 290 300
LEYPDDYQGP RDGEYKTPYA VVQLRQDNAA GSLYNIVGFQ THLKWGEQKR
310 320 330 340 350
VFQMIPGLEN AEFVRYGVMH RNSYMDSPNL LEQTFRSKKL PNLFFAGQMT
360 370 380 390 400
GVEGYVESAA SGLVAGINAA RLFKGEEALV FPETTAIGSL PHYVTHADSK
410 420 430 440
HFQPMNVNFG IIKELDGPRI RDKKERYEKI AERALQDLQP YLDK
Length:444
Mass (Da):49,289
Last modified:March 20, 2007 - v1
Checksum:i692714C4E37DF096
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA Translation: ABN44587.1
RefSeqiWP_011836971.1, NC_009009.1
YP_001035137.1, NC_009009.1

Genome annotation databases

EnsemblBacteriaiABN44587; ABN44587; SSA_1182
GeneIDi4806413
KEGGissa:SSA_1182
PATRICifig|388919.9.peg.1124

Entry informationi

Entry nameiTRMFO_STRSV
AccessioniPrimary (citable) accession number: A3CN32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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