A3CMY9 (XPT_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xanthine phosphoribosyltransferase
Short name=XPRTase
EC=2.4.2.22

Gene names

Name:	xpt
Ordered Locus Names:	SSA_1134

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus sanguis

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity. HAMAP-Rule MF_01184
Catalytic activity	XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. HAMAP-Rule MF_01184
Pathway	Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. HAMAP-Rule MF_01184
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01184.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
Sequence caution	The sequence ABN44544.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	XMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway purine ribonucleoside salvage Inferred from electronic annotation. Source: HAMAP xanthine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	xanthine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Xanthine phosphoribosyltransferase HAMAP-Rule MF_01184		PRO_0000339776
Regions
	Region	128 – 132	5	5-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Sites
	Binding site	20	1	Xanthine; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	27	1	Xanthine By similarity
	Binding site	156	1	Xanthine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3CMY9 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: DBAF9B098FF8C97F	FASTA	193	20,823
	10 20 30 40 50 60 MKKLEERILR DGQVLGENIL KVDSFLTHQV DFSLMKEIGQ VFAEAVKDAG ITKVVTIEAS 70 80 90 100 110 120 GIAPAVYVAE ALGLPMIFAK KAKNITMTEG ILTAEVYSFT KQVTSTVSIA GKFLNSDDKV 130 140 150 160 170 180 LIIDDFLANG QAAKGLITII EQAGAQIEAV GIVIEKSFQD GRQLLETAGY RVLSLARIAG 190 FEKGQIVFTE ADI

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN44544.1. Different initiation.
RefSeq	YP_001035094.1. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CMY9.
SMR	A3CMY9. Positions 1-190.
ModBase	Search...
Protein-protein interaction databases
STRING	388919.SSA_1134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN44544; ABN44544; SSA_1134.
GeneID	4808079.
KEGG	ssa:SSA_1134.
PATRIC	19769234. VBIStrSan33173_1078.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0503.
HOGENOM	HOG000036777.
KO	K03816.
ProtClustDB	PRK09219.
Enzyme and pathway databases
UniPathway	UPA00602; UER00658.
Family and domain databases
HAMAP	MF_01184. XPRTase.
InterPro	IPR000836. PRibTrfase_dom. IPR010079. Xanthine_PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01744. XPRTase. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XPT_STRSV

Accession

Primary (citable) accession number: A3CMY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 1, 2013
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program