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A3CMU9

- TYSY_STRSV

UniProt

A3CMU9 - TYSY_STRSV

Protein

Thymidylate synthase

Gene

thyA

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei154 – 1541UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSSAN388919:GHEN-1076-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:SSA_1091
    OrganismiStreptococcus sanguinis (strain SK36)
    Taxonomic identifieri388919 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002148: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Thymidylate synthasePRO_1000000695Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi388919.SSA_1091.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CMU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257898.
    KOiK00560.
    OMAiELLWIYQ.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CMU9-1 [UniParc]FASTAAdd to Basket

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    MTLADTIFKE NIKKIMEQGV FSENARPRYK DGNVANSKYI TGSFAEYDLS    50
    KGEFPITTLR PIAIKSAIKE VLWIYQDQSN SLELLNDKYN VHYWNDWEVG 100
    DTGTIGQRYG AVVKKHNIIN KILQQLEANP WNRRNIISLW DYEAFEETDG 150
    LLPCAFQTMF DVRRVDGDIY LDATLTQRSN DMLVAHHINA MQYVALQMMI 200
    AKHFGWKVGK FFYFINNLHI YDNQFEQAEE LLRREPSDCH PRLVLNVPDG 250
    TNFFDIKAED FELLDYNPVK PQLKFDLAI 279
    Length:279
    Mass (Da):32,562
    Last modified:March 20, 2007 - v1
    Checksum:i587738B359745A7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000387 Genomic DNA. Translation: ABN44504.1.
    RefSeqiYP_001035054.1. NC_009009.1.

    Genome annotation databases

    EnsemblBacteriaiABN44504; ABN44504; SSA_1091.
    GeneIDi4807197.
    KEGGissa:SSA_1091.
    PATRICi19769152. VBIStrSan33173_1037.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000387 Genomic DNA. Translation: ABN44504.1 .
    RefSeqi YP_001035054.1. NC_009009.1.

    3D structure databases

    ProteinModelPortali A3CMU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 388919.SSA_1091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN44504 ; ABN44504 ; SSA_1091 .
    GeneIDi 4807197.
    KEGGi ssa:SSA_1091.
    PATRICi 19769152. VBIStrSan33173_1037.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257898.
    KOi K00560.
    OMAi ELLWIYQ.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci SSAN388919:GHEN-1076-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK36.

    Entry informationi

    Entry nameiTYSY_STRSV
    AccessioniPrimary (citable) accession number: A3CMU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3