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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptococcus sanguinis (strain SK36)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GTPUniRule annotation1
Binding sitei144GTPUniRule annotation1
Binding sitei188GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26GTPUniRule annotation5
Nucleotide bindingi109 – 111GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAN388919:SSA_0656-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:SSA_0656Imported
OrganismiStreptococcus sanguinis (strain SK36)Imported
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002148 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi388919.SSA_0656

Structurei

3D structure databases

ProteinModelPortaliA3CLN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 206TubulinInterPro annotationAdd BLAST193
Domaini208 – 325Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK Bacteria
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit

Sequencei

Sequence statusi: Complete.

A3CLN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFSFDAAAA QGAVIKVIGV GGGGGNAINR MIDEGVAGVE FIAANTDVQA
60 70 80 90 100
LSSAKAETVI QLGPKLTRGL GAGGQPEVGR KAAEESEEVL TEALQGADMV
110 120 130 140 150
FITAGMGGGS GTGAAPVIAR IAKNVGALTV AVVTRPFGFE GSKRGTFAVE
160 170 180 190 200
GINELREHVD TLLIISNNNL LEIVDKKTPL LEALSEADNV LRQGVQGITD
210 220 230 240 250
LITSPGLINL DFADVKTVMA DKGNALMGIG VGSGEERVIE AARKAIYSPL
260 270 280 290 300
LETTIDGAED VIVNVTGGLD MTLIEAEEAS EIVNQAAGHG VNIWLGTAID
310 320 330 340 350
ESMKDEIRVT VVATGVRQDK VEKVSGIRQT PQPTSPSRPQ QVEPNREVRS
360 370 380 390 400
GQFERNFDMT ETVDIPAPSR QRTDAPKGSA FGDWDLRREA IVRQAEPSSS
410 420
ARVERYAETN EDDDELETPP FFRNR
Length:425
Mass (Da):44,948
Last modified:March 20, 2007 - v1
Checksum:i29B4981C31C8ADF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA Translation: ABN44094.1
RefSeqiWP_011836648.1, NC_009009.1
YP_001034644.1, NC_009009.1

Genome annotation databases

EnsemblBacteriaiABN44094; ABN44094; SSA_0656
GeneIDi4806614
KEGGissa:SSA_0656
PATRICifig|388919.9.peg.630

Similar proteinsi

Entry informationi

Entry nameiA3CLN9_STRSV
AccessioniPrimary (citable) accession number: A3CLN9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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