A3CLL9 (TRPC_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SSA_0635

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018556

Sequences

	Sequence		Length	Mass (Da)
	A3CLL9 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 25930D1FAADEBF36	FASTA	255	28,584
	10 20 30 40 50 60 MSKEFLPTIL KQKEQEVAAM SYEELQPLRS TYSLYEYLKN HPQELQLIAE VKKASPSLGD 70 80 90 100 110 120 INLGVDIVEQ ARTYERCGAA MISVLTDEIF FKGHLDYLRE ISSQVTIPTL NKDFIIDEKQ 130 140 150 160 170 180 IVRARNAGAT VILLIVAALS EKRLQELYDF ATGLGLEVLV ETHNLAELET AHRIGAQIIG 190 200 210 220 230 240 VNNRNLVTFE TDINTSLQLS AHFKDDRVYV SESAIFSKED AELVAPYFHA VLVGTALMQA 250 ENVAEKIKEL KIDKG

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed: 17277061] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN44074.1.
RefSeq	YP_001034624.1. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CLL9.
ModBase	Search...
Protein-protein interaction databases
STRING	A3CLL9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000051517; EBSTRP00000047781; EBSTRG00000051507.
GeneID	4806581.
GenomeReviews	Gene locus SSA_0635 in contig CP000387_GR.
KEGG	ssa:SSA_0635.
NMPDR	fig|388919.8.peg.573.
PATRIC	19768298. VBIStrSan33173_0611.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000029214.
HOGENOM	HBG540956.
OMA	FETDINT.
PhylomeDB	A3CLL9.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STRSV

Accession

Primary (citable) accession number: A3CLL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 20, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program