A3CL81 (GSA_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	SSA_0488

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus sanguis

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_1000079937
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3CL81 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 19D17EF50ABF9F65	FASTA	432	46,820
	10 20 30 40 50 60 MKREHSNQYF TEAQKLFPGG VNSPVRAFKA VGGHPLFIEK ASGAYLHDVD GNRYIDYVLS 70 80 90 100 110 120 WGPMILGHAP KDVLPAVEEA IWEGTSFGAP SPREIALGQL VQERLPFMER MRMVNSGTEA 130 140 150 160 170 180 TMSAIRVARG VTKRSKIVKF IGCYHGHSDS FLVQAGSGLA SFGIADSAGV IAQVAGETLA 190 200 210 220 230 240 LPYNDTDALK TCFEKYGDDI ACVILEAVAG NMGLIPADAD FINTIRSLTQ EYGSLFIVDE 250 260 270 280 290 300 VMSGFRAHYQ GAVGLYQTEP DLVCLGKVIG GGFPVAAFGG KAVYMDQVAP LGSIYQAGTL 310 320 330 340 350 360 SGNPVAMTAG YETLKQLTPE LFAEIEEKTS YLCDGLRSLA DKYSISLQVV SKGTMFGFFF 370 380 390 400 410 420 SQKPVRNFED SKAADHAQFA RLHGLLLEEG IYLAPSQYET NFMSSAHTRA DLDQTLAAFE 430 QAFQEMKEEA NG

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN43936.1.
RefSeq	YP_001034486.1. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CL81.
ModBase	Search...
Protein-protein interaction databases
STRING	388919.SSA_0488.
Proteomic databases
PRIDE	A3CL81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN43936; ABN43936; SSA_0488.
GeneID	4807429.
KEGG	ssa:SSA_0488.
PATRIC	19768020. VBIStrSan33173_0472.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	FGHADEE.
Enzyme and pathway databases
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_STRSV

Accession

Primary (citable) accession number: A3CL81

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 20, 2007
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program