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A3CL27 (FTHS1_STRSV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase 1

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name=FHS 1
Short name=FTHFS 1
Gene names
Name:fhs1
Ordered Locus Names:SSA_0432
OrganismStreptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]
Taxonomic identifier388919 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence caution

The sequence ABN43882.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557Formate--tetrahydrofolate ligase 1 HAMAP-Rule MF_01543
PRO_0000293069

Regions

Nucleotide binding66 – 738ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A3CL27 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: E84BD4012405BAEC

FASTA55759,000
        10         20         30         40         50         60 
MVLSDIEIAN SVQMKSIKEV AEKLGIAEDA LSLYGNYKAK ISAGQLEALK DKPDGKLILV 

        70         80         90        100        110        120 
TAISPTPAGE GKTTTSVGLV DALAAIGKKA VIALREPSLG PVFGIKGGAA GGGHAQVVPM 

       130        140        150        160        170        180 
EDINLHFTGD FHAIGVANNL LAALIDNHIH HGNALGIDSR RITWKRAVDM NDRQLRHIVD 

       190        200        210        220        230        240 
GLQGKVNGVP REDGFDITVA SEVMAILCLS ENITDLKNRL EKIIIGYSFE GKPVTAKDLK 

       250        260        270        280        290        300 
AGGAMAAVLK DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYADYAVTEA 

       310        320        330        340        350        360 
GFGADLGAEK FIDIKCRTSG LRPAAVVLVA TIRALKMHGG VAKSDLAEEN VQAVVDGLPN 

       370        380        390        400        410        420 
LEKHLENIQD VYGLPAVVAI NKFPLDTEAE LQAVYDACQK RGVDVVISDV WANGGAGGKE 

       430        440        450        460        470        480 
LAEKVVELAE GDNHFQFVYN EEDSIETKLN KIVTKVYGGK GVRLTPAAKR ELKQLDELGF 

       490        500        510        520        530        540 
SNYPICMAKT QYSFSDDAKK LGAPKDFVVT ISQLKVSAGA GFIVALTGAI MTMPGLPKVP 

       550 
ASEKIDVDKD GNISGLF 

« Hide

References

[1]"Genome of the opportunistic pathogen Streptococcus sanguinis."
Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A.
J. Bacteriol. 189:3166-3175(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SK36.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000387 Genomic DNA. Translation: ABN43882.1. Different initiation.
RefSeqYP_001034432.2. NC_009009.1.

3D structure databases

ProteinModelPortalA3CL27.
SMRA3CL27. Positions 5-555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING388919.SSA_0432.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN43882; ABN43882; SSA_0432.
GeneID4808102.
KEGGssa:SSA_0432.
PATRIC19767912. VBIStrSan33173_0418.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycSSAN388919:GHEN-453-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS1_STRSV
AccessionPrimary (citable) accession number: A3CL27
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways