A3CL27 (FTHS1_STRSV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 1
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name=FHS 1
Short name=FTHFS 1

Gene names

Name:	fhs1
Ordered Locus Names:	SSA_0432

Organism

Streptococcus sanguinis (strain SK36) [Complete proteome] [HAMAP]

Taxonomic identifier

388919 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus sanguis

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.
Sequence caution	The sequence ABN43882.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	Formate--tetrahydrofolate ligase 1 HAMAP-Rule MF_01543		PRO_0000293069
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3CL27 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: E84BD4012405BAEC	FASTA	557	59,000
	10 20 30 40 50 60 MVLSDIEIAN SVQMKSIKEV AEKLGIAEDA LSLYGNYKAK ISAGQLEALK DKPDGKLILV 70 80 90 100 110 120 TAISPTPAGE GKTTTSVGLV DALAAIGKKA VIALREPSLG PVFGIKGGAA GGGHAQVVPM 130 140 150 160 170 180 EDINLHFTGD FHAIGVANNL LAALIDNHIH HGNALGIDSR RITWKRAVDM NDRQLRHIVD 190 200 210 220 230 240 GLQGKVNGVP REDGFDITVA SEVMAILCLS ENITDLKNRL EKIIIGYSFE GKPVTAKDLK 250 260 270 280 290 300 AGGAMAAVLK DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYADYAVTEA 310 320 330 340 350 360 GFGADLGAEK FIDIKCRTSG LRPAAVVLVA TIRALKMHGG VAKSDLAEEN VQAVVDGLPN 370 380 390 400 410 420 LEKHLENIQD VYGLPAVVAI NKFPLDTEAE LQAVYDACQK RGVDVVISDV WANGGAGGKE 430 440 450 460 470 480 LAEKVVELAE GDNHFQFVYN EEDSIETKLN KIVTKVYGGK GVRLTPAAKR ELKQLDELGF 490 500 510 520 530 540 SNYPICMAKT QYSFSDDAKK LGAPKDFVVT ISQLKVSAGA GFIVALTGAI MTMPGLPKVP 550 ASEKIDVDKD GNISGLF

References

[1]

"Genome of the opportunistic pathogen Streptococcus sanguinis." Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P., Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D., Paik S., Peterson D.L., Macrina F.L., Buck G.A. J. Bacteriol. 189:3166-3175(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SK36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000387 Genomic DNA. Translation: ABN43882.1. Different initiation.
RefSeq	YP_001034432.2. NC_009009.1.
3D structure databases
ProteinModelPortal	A3CL27.
SMR	A3CL27. Positions 5-555.
ModBase	Search...
Protein-protein interaction databases
STRING	388919.SSA_0432.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN43882; ABN43882; SSA_0432.
GeneID	4808102.
KEGG	ssa:SSA_0432.
PATRIC	19767912. VBIStrSan33173_0418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	SSAN388919:GHEN-453-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS1_STRSV

Accession

Primary (citable) accession number: A3CL27

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	May 29, 2013
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program