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A3CL27

- FTHS1_STRSV

UniProt

A3CL27 - FTHS1_STRSV

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Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAN388919:GHEN-453-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 1UniRule annotation
Short name:
FHS 1UniRule annotation
Short name:
FTHFS 1UniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Ordered Locus Names:SSA_0432
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligase 1PRO_0000293069Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_0432.

Structurei

3D structure databases

ProteinModelPortaliA3CL27.
SMRiA3CL27. Positions 5-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CL27-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSDIEIAN SVQMKSIKEV AEKLGIAEDA LSLYGNYKAK ISAGQLEALK
60 70 80 90 100
DKPDGKLILV TAISPTPAGE GKTTTSVGLV DALAAIGKKA VIALREPSLG
110 120 130 140 150
PVFGIKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH
160 170 180 190 200
HGNALGIDSR RITWKRAVDM NDRQLRHIVD GLQGKVNGVP REDGFDITVA
210 220 230 240 250
SEVMAILCLS ENITDLKNRL EKIIIGYSFE GKPVTAKDLK AGGAMAAVLK
260 270 280 290 300
DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYADYAVTEA
310 320 330 340 350
GFGADLGAEK FIDIKCRTSG LRPAAVVLVA TIRALKMHGG VAKSDLAEEN
360 370 380 390 400
VQAVVDGLPN LEKHLENIQD VYGLPAVVAI NKFPLDTEAE LQAVYDACQK
410 420 430 440 450
RGVDVVISDV WANGGAGGKE LAEKVVELAE GDNHFQFVYN EEDSIETKLN
460 470 480 490 500
KIVTKVYGGK GVRLTPAAKR ELKQLDELGF SNYPICMAKT QYSFSDDAKK
510 520 530 540 550
LGAPKDFVVT ISQLKVSAGA GFIVALTGAI MTMPGLPKVP ASEKIDVDKD

GNISGLF
Length:557
Mass (Da):59,000
Last modified:July 10, 2007 - v2
Checksum:iE84BD4012405BAEC
GO

Sequence cautioni

The sequence ABN43882.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA. Translation: ABN43882.1. Different initiation.
RefSeqiYP_001034432.2. NC_009009.1.

Genome annotation databases

EnsemblBacteriaiABN43882; ABN43882; SSA_0432.
GeneIDi4808102.
KEGGissa:SSA_0432.
PATRICi19767912. VBIStrSan33173_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000387 Genomic DNA. Translation: ABN43882.1 . Different initiation.
RefSeqi YP_001034432.2. NC_009009.1.

3D structure databases

ProteinModelPortali A3CL27.
SMRi A3CL27. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 388919.SSA_0432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN43882 ; ABN43882 ; SSA_0432 .
GeneIDi 4808102.
KEGGi ssa:SSA_0432.
PATRICi 19767912. VBIStrSan33173_0418.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSAN388919:GHEN-453-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK36.

Entry informationi

Entry nameiFTHS1_STRSV
AccessioniPrimary (citable) accession number: A3CL27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3