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A3CL27

- FTHS1_STRSV

UniProt

A3CL27 - FTHS1_STRSV

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Protein
Formate--tetrahydrofolate ligase 1
Gene
fhs1, SSA_0432
Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSAN388919:GHEN-453-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name:
FHS 1
Short name:
FTHFS 1
Gene namesi
Name:fhs1
Ordered Locus Names:SSA_0432
OrganismiStreptococcus sanguinis (strain SK36)
Taxonomic identifieri388919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002148: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligase 1UniRule annotation
PRO_0000293069Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi388919.SSA_0432.

Structurei

3D structure databases

ProteinModelPortaliA3CL27.
SMRiA3CL27. Positions 5-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3CL27-1 [UniParc]FASTAAdd to Basket

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MVLSDIEIAN SVQMKSIKEV AEKLGIAEDA LSLYGNYKAK ISAGQLEALK    50
DKPDGKLILV TAISPTPAGE GKTTTSVGLV DALAAIGKKA VIALREPSLG 100
PVFGIKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH 150
HGNALGIDSR RITWKRAVDM NDRQLRHIVD GLQGKVNGVP REDGFDITVA 200
SEVMAILCLS ENITDLKNRL EKIIIGYSFE GKPVTAKDLK AGGAMAAVLK 250
DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYADYAVTEA 300
GFGADLGAEK FIDIKCRTSG LRPAAVVLVA TIRALKMHGG VAKSDLAEEN 350
VQAVVDGLPN LEKHLENIQD VYGLPAVVAI NKFPLDTEAE LQAVYDACQK 400
RGVDVVISDV WANGGAGGKE LAEKVVELAE GDNHFQFVYN EEDSIETKLN 450
KIVTKVYGGK GVRLTPAAKR ELKQLDELGF SNYPICMAKT QYSFSDDAKK 500
LGAPKDFVVT ISQLKVSAGA GFIVALTGAI MTMPGLPKVP ASEKIDVDKD 550
GNISGLF 557
Length:557
Mass (Da):59,000
Last modified:July 10, 2007 - v2
Checksum:iE84BD4012405BAEC
GO

Sequence cautioni

The sequence ABN43882.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN43882.1. Different initiation.
RefSeqiYP_001034432.2. NC_009009.1.

Genome annotation databases

EnsemblBacteriaiABN43882; ABN43882; SSA_0432.
GeneIDi4808102.
KEGGissa:SSA_0432.
PATRICi19767912. VBIStrSan33173_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000387 Genomic DNA. Translation: ABN43882.1 . Different initiation.
RefSeqi YP_001034432.2. NC_009009.1.

3D structure databases

ProteinModelPortali A3CL27.
SMRi A3CL27. Positions 5-555.
ModBasei Search...

Protein-protein interaction databases

STRINGi 388919.SSA_0432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN43882 ; ABN43882 ; SSA_0432 .
GeneIDi 4808102.
KEGGi ssa:SSA_0432.
PATRICi 19767912. VBIStrSan33173_0418.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SSAN388919:GHEN-453-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SK36.

Entry informationi

Entry nameiFTHS1_STRSV
AccessioniPrimary (citable) accession number: A3CL27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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