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A3CL27

- FTHS1_STRSV

UniProt

A3CL27 - FTHS1_STRSV

Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Streptococcus sanguinis (strain SK36)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSAN388919:GHEN-453-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 1UniRule annotation
    Short name:
    FHS 1UniRule annotation
    Short name:
    FTHFS 1UniRule annotation
    Gene namesi
    Name:fhs1UniRule annotation
    Ordered Locus Names:SSA_0432
    OrganismiStreptococcus sanguinis (strain SK36)
    Taxonomic identifieri388919 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002148: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligase 1PRO_0000293069Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi388919.SSA_0432.

    Structurei

    3D structure databases

    ProteinModelPortaliA3CL27.
    SMRiA3CL27. Positions 5-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3CL27-1 [UniParc]FASTAAdd to Basket

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    MVLSDIEIAN SVQMKSIKEV AEKLGIAEDA LSLYGNYKAK ISAGQLEALK    50
    DKPDGKLILV TAISPTPAGE GKTTTSVGLV DALAAIGKKA VIALREPSLG 100
    PVFGIKGGAA GGGHAQVVPM EDINLHFTGD FHAIGVANNL LAALIDNHIH 150
    HGNALGIDSR RITWKRAVDM NDRQLRHIVD GLQGKVNGVP REDGFDITVA 200
    SEVMAILCLS ENITDLKNRL EKIIIGYSFE GKPVTAKDLK AGGAMAAVLK 250
    DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYADYAVTEA 300
    GFGADLGAEK FIDIKCRTSG LRPAAVVLVA TIRALKMHGG VAKSDLAEEN 350
    VQAVVDGLPN LEKHLENIQD VYGLPAVVAI NKFPLDTEAE LQAVYDACQK 400
    RGVDVVISDV WANGGAGGKE LAEKVVELAE GDNHFQFVYN EEDSIETKLN 450
    KIVTKVYGGK GVRLTPAAKR ELKQLDELGF SNYPICMAKT QYSFSDDAKK 500
    LGAPKDFVVT ISQLKVSAGA GFIVALTGAI MTMPGLPKVP ASEKIDVDKD 550
    GNISGLF 557
    Length:557
    Mass (Da):59,000
    Last modified:July 10, 2007 - v2
    Checksum:iE84BD4012405BAEC
    GO

    Sequence cautioni

    The sequence ABN43882.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000387 Genomic DNA. Translation: ABN43882.1. Different initiation.
    RefSeqiYP_001034432.2. NC_009009.1.

    Genome annotation databases

    EnsemblBacteriaiABN43882; ABN43882; SSA_0432.
    GeneIDi4808102.
    KEGGissa:SSA_0432.
    PATRICi19767912. VBIStrSan33173_0418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000387 Genomic DNA. Translation: ABN43882.1 . Different initiation.
    RefSeqi YP_001034432.2. NC_009009.1.

    3D structure databases

    ProteinModelPortali A3CL27.
    SMRi A3CL27. Positions 5-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 388919.SSA_0432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN43882 ; ABN43882 ; SSA_0432 .
    GeneIDi 4808102.
    KEGGi ssa:SSA_0432.
    PATRICi 19767912. VBIStrSan33173_0418.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SSAN388919:GHEN-453-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SK36.

    Entry informationi

    Entry nameiFTHS1_STRSV
    AccessioniPrimary (citable) accession number: A3CL27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3