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Protein

Serine/threonine-protein phosphatase PP2A-4 catalytic subunit

Gene

PP2A4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi64Manganese 1By similarity1
Metal bindingi90Manganese 1By similarity1
Metal bindingi90Manganese 2By similarity1
Metal bindingi122Manganese 2By similarity1
Active sitei123Proton donorBy similarity1
Metal bindingi172Manganese 2By similarity1
Metal bindingi246Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.16 4460
ReactomeiR-OSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-OSA-198753 ERK/MAPK targets
R-OSA-202670 ERKs are inactivated
R-OSA-69231 Cyclin D associated events in G1
R-OSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-OSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-4 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A4
Ordered Locus Names:Os10g0410600, LOC_Os10g27050
ORF Names:OsJ_030257, OsJ_31490Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 10

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588641 – 314Serine/threonine-protein phosphatase PP2A-4 catalytic subunitAdd BLAST314

Proteomic databases

PaxDbiA3C4N5
PRIDEiA3C4N5

Expressioni

Gene expression databases

ExpressionAtlasiA3C4N5 differential
GenevisibleiA3C4N5 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os10g27050.1

Structurei

3D structure databases

ProteinModelPortaliA3C4N5
SMRiA3C4N5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
InParanoidiA3C4N5
KOiK04382
OMAiREHITIL
OrthoDBiEOG09360EXD

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

A3C4N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESVGSRGG GGGGLDAQIE QLMECRPLSE PEVKTLCEKA KEILMEESNV
60 70 80 90 100
QPVKSPVTIC GDIHGQFHDL VELFRIGGKC PDTNYLFMGD YVDRGYYSVE
110 120 130 140 150
TVTLLVALKV RYPQRITILR GNHESRQITQ VYGFYDECLR KYGSANVWKI
160 170 180 190 200
FTDLFDYFPL TALVESEIFC LHGGLSPSID NLDSVRSLDR VQEVPHEGPM
210 220 230 240 250
CDLLWSDPDD RCGWGISPRG AGYTFGQDIS EQFNHTNNLK LVARAHQLVM
260 270 280 290 300
EGYNWAHEQK VVTIFSAPNY CYRCGNMASI LEVDDCRNHT FIQFEPAPRR
310
GEPDVTRRTP DYFL
Length:314
Mass (Da):35,625
Last modified:September 11, 2007 - v2
Checksum:i93FDD4035DF45F5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000086 Genomic DNA Translation: ABB47590.1
AP008216 Genomic DNA Translation: BAF26492.1
AP014966 Genomic DNA Translation: BAT10803.1
CM000147 Genomic DNA Translation: EEE50943.1
AK099604 mRNA Translation: BAG94218.1
RefSeqiXP_015615022.1, XM_015759536.1
UniGeneiOs.56095

Genome annotation databases

EnsemblPlantsiOs10t0410600-02; Os10t0410600-02; Os10g0410600
GeneIDi4348601
GrameneiOs10t0410600-02; Os10t0410600-02; Os10g0410600
KEGGiosa:4348601

Similar proteinsi

Entry informationi

Entry nameiPP2A4_ORYSJ
AccessioniPrimary (citable) accession number: A3C4N5
Secondary accession number(s): B7EPC1
, Q0IXS3, Q338E3, Q9SBW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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