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UniProtKB - A3C4N5 (PP2A4_ORYSJ)

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Protein

Serine/threonine-protein phosphatase PP2A-4 catalytic subunit

Gene

PP2A4

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi64Manganese 1By similarity1
Metal bindingi90Manganese 1By similarity1
Metal bindingi90Manganese 2By similarity1
Metal bindingi122Manganese 2By similarity1
Active sitei123Proton donorBy similarity1
Metal bindingi172Manganese 2By similarity1
Metal bindingi246Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.16. 4460.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-4 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A4
Ordered Locus Names:Os10g0410600, LOC_Os10g27050
ORF Names:OsJ_030257, OsJ_31490Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza ›
Proteomesi
  • UP000059680 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588641 – 314Serine/threonine-protein phosphatase PP2A-4 catalytic subunitAdd BLAST314

Proteomic databases

PaxDbiA3C4N5.
PRIDEiA3C4N5.

Expressioni

Gene expression databases

ExpressionAtlasiA3C4N5. baseline and differential.
GenevisibleiA3C4N5. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os10g27050.1.

Structurei

3D structure databases

ProteinModelPortaliA3C4N5.
SMRiA3C4N5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
InParanoidiA3C4N5.
KOiK04382.
OMAiHCARERE.
OrthoDBiEOG09360EXD.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A3C4N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESVGSRGG GGGGLDAQIE QLMECRPLSE PEVKTLCEKA KEILMEESNV 
        60         70         80         90        100
QPVKSPVTIC GDIHGQFHDL VELFRIGGKC PDTNYLFMGD YVDRGYYSVE 
       110        120        130        140        150
TVTLLVALKV RYPQRITILR GNHESRQITQ VYGFYDECLR KYGSANVWKI 
       160        170        180        190        200
FTDLFDYFPL TALVESEIFC LHGGLSPSID NLDSVRSLDR VQEVPHEGPM 
       210        220        230        240        250
CDLLWSDPDD RCGWGISPRG AGYTFGQDIS EQFNHTNNLK LVARAHQLVM 
       260        270        280        290        300
EGYNWAHEQK VVTIFSAPNY CYRCGNMASI LEVDDCRNHT FIQFEPAPRR 
       310 
GEPDVTRRTP DYFL
Length:314
Mass (Da):35,625
Last modified:September 11, 2007 - v2
Checksum:i93FDD4035DF45F5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000086 Genomic DNA. Translation: ABB47590.1.
AP008216 Genomic DNA. Translation: BAF26492.1.
AP014966 Genomic DNA. Translation: BAT10803.1.
CM000147 Genomic DNA. Translation: EEE50943.1.
AK099604 mRNA. Translation: BAG94218.1.
RefSeqiXP_015615022.1. XM_015759536.1.
UniGeneiOs.56095.

Genome annotation databases

EnsemblPlantsiOS10T0410600-02; OS10T0410600-02; OS10G0410600.
GeneIDi4348601.
GrameneiOS10T0410600-02; OS10T0410600-02; OS10G0410600.
KEGGiosa:4348601.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPP2A4_ORYSJ
AccessioniPrimary (citable) accession number: A3C4N5
Secondary accession number(s): B7EPC1
, Q0IXS3, Q338E3, Q9SBW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 7, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families