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Protein

Metallothionein-like protein 2C

Gene

MT2C

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Acts as reactive oxygen species (ROS) scavenger in the cytosol. Possesses superoxide anion and hydroxyl radical scavenging activities in vitro (PubMed:15220467). Plays a role during root development, lateral root initiation and seed embryo germination, possibly by regulating levels of cytokinin (PubMed:18258694).Curated2 Publications

Miscellaneous

Down-regulation by RAC1 during pathogen infection may potentiate ROS which function as signals in resistance response (PubMed:15220467). Plants silencing MT2C show abnormal plant growth and root formation (PubMed:18258694).2 Publications

GO - Molecular functioni

GO - Biological processi

  • reactive oxygen species metabolic process Source: UniProtKB

Keywordsi

Biological processStress response
LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 2C
Alternative name(s):
Class I metallothionein-like protein 2C
OsMT-I-2c
OsMT2b
Gene namesi
Name:MT2C
Synonyms:MTE
Ordered Locus Names:Os05g0111300, LOC_Os05g02070
ORF Names:OsJ_016110, P0016H04.13
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974081 – 84Metallothionein-like protein 2CAdd BLAST84

Proteomic databases

PRIDEiA3AZ88.

Expressioni

Tissue specificityi

Highly expressed in inflorescences. Expressed in roots and leaves (PubMed:15220467, PubMed:17002881). Expressed in root primordium, pericycle, phloem and in the basal parts of lateral roots (PubMed:18258694).3 Publications

Developmental stagei

During embryo development, expressed in the top of the scutellum at 7 days after pollination (DAP). In the germinating embryos, expressed in the scutellum and the cap of the radicle at 2 days after germination (DAG). At 4 DAG, still expressed in scutellum, and appears in the vascular bundle of shoot. In florets of young panicle, expressed in the pedicel and the basement of glumes. In florets of older panicle, expressed in the pedicel, basement of glumes, anthers and pistils. Expressed in the basal parts of ovaries before pollination and in the basal parts of stigmas and ovaries after pollination.1 Publication

Inductioni

By Fe, Zn and auxin in roots, and Cu and Mn in shoots. Down-regulated by cytokinin and cold stress in roots and shoots. Down-regulated by Cu and salt stress in roots (PubMed:18258694). Sinergically down-regulated by RAC1 and sphingolipid elicitor (PubMed:15220467).2 Publications

Gene expression databases

ExpressionAtlasiA3AZ88. baseline and differential.
GenevisibleiA3AZ88. OS.

Structurei

3D structure databases

ProteinModelPortaliA3AZ88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiA3AZ88.
OMAiMVIAEAT.
OrthoDBiEOG093611IU.

Family and domain databases

InterProiView protein in InterPro
IPR000347. Metalthion_15p.
PANTHERiPTHR33543. PTHR33543. 1 hit.
PfamiView protein in Pfam
PF01439. Metallothio_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A3AZ88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCCGGNCGC GSGCQCGGGC GGCKMFPDVE ATATTKTFVL AAPSNKASSG
60 70 80
GMEMAVESGE NGGCGCNTCK CGTSCSGCSC CSCN
Length:84
Mass (Da):7,969
Last modified:March 20, 2007 - v1
Checksum:i5BF71575A9142311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57638 mRNA. Translation: AAD10192.1.
AF048750 Genomic DNA. Translation: AAD02475.1.
AC079356 Genomic DNA. Translation: AAU44207.1.
AP008211 Genomic DNA. Translation: BAF16361.1.
AP014961 Genomic DNA. Translation: BAS91926.1.
CM000142 Genomic DNA. Translation: EAZ32627.1.
RefSeqiXP_015638726.1. XM_015783240.1.
UniGeneiOs.100198.
Os.18500.
Os.73772.
Os.74845.

Genome annotation databases

EnsemblPlantsiOS05T0111300-01; OS05T0111300-01; OS05G0111300.
GeneIDi4337596.
GrameneiOS05T0111300-01; OS05T0111300-01; OS05G0111300.
KEGGiosa:4337596.

Similar proteinsi

Entry informationi

Entry nameiMT2C_ORYSJ
AccessioniPrimary (citable) accession number: A3AZ88
Secondary accession number(s): P93433, Q0DLB2, Q65XV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 20, 2007
Last modified: November 22, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families