A3AZ88 (MT2C_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metallothionein-like protein 2C

Alternative name(s):
Class I metallothionein-like protein 2C
OsMT-I-2c
OsMT2b

Gene names

Name:	MT2C
Synonyms:	MTE
Ordered Locus Names:	Os05g0111300, LOC_Os05g02070
ORF Names:	OsJ_016110, P0016H04.13

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	84 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals. Ref.6 Acts as reactive oxygen species (ROS) scavenger in the cytosol. Possesses superoxide- and hydroxyl radical-scavenging activities in vitro. Ref.6
Subcellular location	Cytoplasm › cytosol Ref.6.
Tissue specificity	Highly expressed in inflorescences. Expressed in roots and leaves. Ref.6 Ref.7
Induction	Sinergically down-regulated by RAC1 and sphingolipid elicitor. Ref.6
Miscellaneous	Down-regulation by RAC1 during pathogen infection may potentiate ROS which function as signals in resistance response.
Sequence similarities	Belongs to the metallothionein superfamily. Type 15 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Metal-thiolate cluster
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 84	84	Metallothionein-like protein 2C		PRO_0000197408

Sequences

	Sequence		Length	Mass (Da)
	A3AZ88 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 5BF71575A9142311	FASTA	84	7,969
	10 20 30 40 50 60 MSCCGGNCGC GSGCQCGGGC GGCKMFPDVE ATATTKTFVL AAPSNKASSG GMEMAVESGE 70 80 NGGCGCNTCK CGTSCSGCSC CSCN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a cDNA clone encoding a type 2 metallothionein-like protein from rice embryo." Chen P.-W., Chen L.-J. Plant Gene Register PGR97-109 Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: cv. Lomello.
[2]	"A fine physical map of the rice chromosome 5." Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y. Mol. Genet. Genomics 274:337-345(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[5]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[6]	"Down-regulation of metallothionein, a reactive oxygen scavenger, by the small GTPase OsRac1 in rice." Wong H.L., Sakamoto T., Kawasaki T., Umemura K., Shimamoto K. Plant Physiol. 135:1447-1456(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
[7]	"Molecular analyses of the metallothionein gene family in rice (Oryza sativa L.)." Zhou G., Xu Y., Li J., Yang L., Liu J.-Y. J. Biochem. Mol. Biol. 39:595-606(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57638 mRNA. Translation: AAD10192.1. AF048750 Genomic DNA. Translation: AAD02475.1. AC079356 Genomic DNA. Translation: AAU44207.1. AP008211 Genomic DNA. Translation: BAF16361.1. CM000142 Genomic DNA. Translation: EAZ32627.1.
RefSeq	NP_001054447.1. NM_001060982.1.
UniGene	Os.74845.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os05g02070.3; LOC_Os05g02070.3; LOC_Os05g02070.
GeneID	4337596.
KEGG	osa:4337596.
Organism-specific databases
Gramene	A3AZ88.
Phylogenomic databases
OMA	CGGCKMF.
ProtClustDB	CLSN2919148.
Gene expression databases
ArrayExpress	A3AZ88.
Family and domain databases
InterPro	IPR000347. Metalthion_15p. [Graphical view]
Pfam	PF01439. Metallothio_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT2C_ORYSJ

Accession

Primary (citable) accession number: A3AZ88
Secondary accession number(s): P93433, Q0DLB2, Q65XV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	March 20, 2007
Last modified:	April 3, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program