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A3AF13

- UBP26_ORYSJ

UniProt

A3AF13 - UBP26_ORYSJ

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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene
UBP26, Os03g0192800, LOC_Os03g09260, OsJ_009385
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151Nucleophile By similarity
Active sitei359 – 3591Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:UBP26
Ordered Locus Names:Os03g0192800, LOC_Os03g09260
ORF Names:OsJ_009385
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiA3AF13.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10791079Ubiquitin carboxyl-terminal hydrolase 26PRO_0000293494Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA3AF13.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 446341USPAdd
BLAST
Domaini495 – 598104DUSP 1Add
BLAST
Domaini613 – 715103DUSP 2Add
BLAST
Domaini738 – 862125DUSP 3Add
BLAST
Domaini961 – 103777Ubiquitin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 3 DUSP domains.
Contains 1 USP domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
KOiK11858.

Family and domain databases

Gene3Di3.30.2230.10. 2 hits.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3AF13-1 [UniParc]FASTAAdd to Basket

« Hide

MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC     50
HGCHGNSKDS PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD 100
STETPAGLTN LGATCYANSI LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ 150
LARLFAQLHS SKMAFIDSAP FIKTLELDNG VQQDSHEFLT LFLSLLEGSL 200
SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME DFYELELNIK 250
GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF 300
QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH 350
KGSAANSGHY VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSDKTD 400
QKPQGSSTAD SVTNDDNNSC HEAAFTSTME EMFSSTDAYM LMYKRIAKDE 450
NGIESNNISS NNSLPHHFVD EIDERNTSYV KECEEYESKK DVHLAYITER 500
RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP IITGVRVHSS 550
IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME 600
CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW 650
LRRKNVDIPS DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE 700
TSGMKIDDIV TFPSDSQPCG ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL 750
TSGKSLALHP GQKYYLVPSS WLSEWRAYIT ATGKNISSLP EPQSLEVTIN 800
SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES DWILFSEEWN 850
VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP 900
YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS 950
AAVPVPDRRT SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN 1000
QELHKGSVEI EDDFATLADK CIFPGDVLWV KDSEIYENRD IADEISEQKV 1050
VVQTEEGFRG TLLTSSASAQ LCQDISFSD 1079
Length:1,079
Mass (Da):119,884
Last modified:July 10, 2007 - v2
Checksum:i70581F22368079E4
GO

Sequence cautioni

The sequence ABF94422.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence BAF11157.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000009 Genomic DNA. Translation: ABF94422.1. Sequence problems.
AP008209 Genomic DNA. Translation: BAF11157.2. Sequence problems.
CM000140 Genomic DNA. No translation available.
RefSeqiNP_001049243.2. NM_001055778.1.
UniGeneiOs.56967.

Genome annotation databases

GeneIDi4331918.
KEGGiosa:4331918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DP000009 Genomic DNA. Translation: ABF94422.1 . Sequence problems.
AP008209 Genomic DNA. Translation: BAF11157.2 . Sequence problems.
CM000140 Genomic DNA. No translation available.
RefSeqi NP_001049243.2. NM_001055778.1.
UniGenei Os.56967.

3D structure databases

ProteinModelPortali A3AF13.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4331918.
KEGGi osa:4331918.

Organism-specific databases

Gramenei A3AF13.

Phylogenomic databases

eggNOGi COG5077.
KOi K11858.

Family and domain databases

Gene3Di 3.30.2230.10. 2 hits.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiUBP26_ORYSJ
AccessioniPrimary (citable) accession number: A3AF13
Secondary accession number(s): Q0DUD1, Q10QK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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