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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

UBP26

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115NucleophilePROSITE-ProRule annotation1
Active sitei359Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.068.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:UBP26
Ordered Locus Names:Os03g0192800, LOC_Os03g09260
ORF Names:OsJ_009385
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002934941 – 1079Ubiquitin carboxyl-terminal hydrolase 26Add BLAST1079

Proteomic databases

PaxDbiA3AF13.

PTM databases

iPTMnetiA3AF13.

Expressioni

Gene expression databases

GenevisibleiA3AF13. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g09260.1.

Structurei

3D structure databases

ProteinModelPortaliA3AF13.
SMRiA3AF13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 446USPAdd BLAST341
Domaini495 – 598DUSP 1PROSITE-ProRule annotationAdd BLAST104
Domaini613 – 715DUSP 2PROSITE-ProRule annotationAdd BLAST103
Domaini738 – 862DUSP 3PROSITE-ProRule annotationAdd BLAST125
Domaini961 – 1037Ubiquitin-likePROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 DUSP domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1863. Eukaryota.
COG5077. LUCA.
InParanoidiA3AF13.
OrthoDBiEOG093600UV.

Family and domain databases

CDDicd02668. Peptidase_C19L. 1 hit.
Gene3Di3.30.2230.10. 2 hits.
InterProiIPR006615. Pept_C19_DUSP.
IPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
IPR033841. USP48.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3AF13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC
60 70 80 90 100
HGCHGNSKDS PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD
110 120 130 140 150
STETPAGLTN LGATCYANSI LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ
160 170 180 190 200
LARLFAQLHS SKMAFIDSAP FIKTLELDNG VQQDSHEFLT LFLSLLEGSL
210 220 230 240 250
SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME DFYELELNIK
260 270 280 290 300
GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF
310 320 330 340 350
QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH
360 370 380 390 400
KGSAANSGHY VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSDKTD
410 420 430 440 450
QKPQGSSTAD SVTNDDNNSC HEAAFTSTME EMFSSTDAYM LMYKRIAKDE
460 470 480 490 500
NGIESNNISS NNSLPHHFVD EIDERNTSYV KECEEYESKK DVHLAYITER
510 520 530 540 550
RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP IITGVRVHSS
560 570 580 590 600
IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME
610 620 630 640 650
CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW
660 670 680 690 700
LRRKNVDIPS DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE
710 720 730 740 750
TSGMKIDDIV TFPSDSQPCG ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL
760 770 780 790 800
TSGKSLALHP GQKYYLVPSS WLSEWRAYIT ATGKNISSLP EPQSLEVTIN
810 820 830 840 850
SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES DWILFSEEWN
860 870 880 890 900
VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP
910 920 930 940 950
YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS
960 970 980 990 1000
AAVPVPDRRT SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN
1010 1020 1030 1040 1050
QELHKGSVEI EDDFATLADK CIFPGDVLWV KDSEIYENRD IADEISEQKV
1060 1070
VVQTEEGFRG TLLTSSASAQ LCQDISFSD
Length:1,079
Mass (Da):119,884
Last modified:July 10, 2007 - v2
Checksum:i70581F22368079E4
GO

Sequence cautioni

The sequence ABF94422 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF11157 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000009 Genomic DNA. Translation: ABF94422.1. Sequence problems.
AP008209 Genomic DNA. Translation: BAF11157.2. Sequence problems.
AP014959 Genomic DNA. No translation available.
CM000140 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000009 Genomic DNA. Translation: ABF94422.1. Sequence problems.
AP008209 Genomic DNA. Translation: BAF11157.2. Sequence problems.
AP014959 Genomic DNA. No translation available.
CM000140 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA3AF13.
SMRiA3AF13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g09260.1.

Protein family/group databases

MEROPSiC19.068.

PTM databases

iPTMnetiA3AF13.

Proteomic databases

PaxDbiA3AF13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1863. Eukaryota.
COG5077. LUCA.
InParanoidiA3AF13.
OrthoDBiEOG093600UV.

Gene expression databases

GenevisibleiA3AF13. OS.

Family and domain databases

CDDicd02668. Peptidase_C19L. 1 hit.
Gene3Di3.30.2230.10. 2 hits.
InterProiIPR006615. Pept_C19_DUSP.
IPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
IPR033841. USP48.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP26_ORYSJ
AccessioniPrimary (citable) accession number: A3AF13
Secondary accession number(s): Q0DUD1, Q10QK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.