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A3AF13

- UBP26_ORYSJ

UniProt

A3AF13 - UBP26_ORYSJ

Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

UBP26

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei115 – 1151NucleophilePROSITE-ProRule annotation
    Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 26
    Ubiquitin thioesterase 26
    Ubiquitin-specific-processing protease 26
    Gene namesi
    Name:UBP26
    Ordered Locus Names:Os03g0192800, LOC_Os03g09260
    ORF Names:OsJ_009385
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 3

    Organism-specific databases

    GrameneiA3AF13.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10791079Ubiquitin carboxyl-terminal hydrolase 26PRO_0000293494Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA3AF13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini106 – 446341USPAdd
    BLAST
    Domaini495 – 598104DUSP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini613 – 715103DUSP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini738 – 862125DUSP 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini961 – 103777Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 DUSP domains.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5077.
    KOiK11858.

    Family and domain databases

    Gene3Di3.30.2230.10. 2 hits.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF06337. DUSP. 2 hits.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3AF13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC     50
    HGCHGNSKDS PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD 100
    STETPAGLTN LGATCYANSI LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ 150
    LARLFAQLHS SKMAFIDSAP FIKTLELDNG VQQDSHEFLT LFLSLLEGSL 200
    SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME DFYELELNIK 250
    GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF 300
    QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH 350
    KGSAANSGHY VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSDKTD 400
    QKPQGSSTAD SVTNDDNNSC HEAAFTSTME EMFSSTDAYM LMYKRIAKDE 450
    NGIESNNISS NNSLPHHFVD EIDERNTSYV KECEEYESKK DVHLAYITER 500
    RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP IITGVRVHSS 550
    IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME 600
    CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW 650
    LRRKNVDIPS DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE 700
    TSGMKIDDIV TFPSDSQPCG ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL 750
    TSGKSLALHP GQKYYLVPSS WLSEWRAYIT ATGKNISSLP EPQSLEVTIN 800
    SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES DWILFSEEWN 850
    VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP 900
    YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS 950
    AAVPVPDRRT SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN 1000
    QELHKGSVEI EDDFATLADK CIFPGDVLWV KDSEIYENRD IADEISEQKV 1050
    VVQTEEGFRG TLLTSSASAQ LCQDISFSD 1079
    Length:1,079
    Mass (Da):119,884
    Last modified:July 10, 2007 - v2
    Checksum:i70581F22368079E4
    GO

    Sequence cautioni

    The sequence ABF94422.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence BAF11157.2 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000009 Genomic DNA. Translation: ABF94422.1. Sequence problems.
    AP008209 Genomic DNA. Translation: BAF11157.2. Sequence problems.
    CM000140 Genomic DNA. No translation available.
    RefSeqiNP_001049243.2. NM_001055778.1.
    UniGeneiOs.56967.

    Genome annotation databases

    GeneIDi4331918.
    KEGGiosa:4331918.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000009 Genomic DNA. Translation: ABF94422.1 . Sequence problems.
    AP008209 Genomic DNA. Translation: BAF11157.2 . Sequence problems.
    CM000140 Genomic DNA. No translation available.
    RefSeqi NP_001049243.2. NM_001055778.1.
    UniGenei Os.56967.

    3D structure databases

    ProteinModelPortali A3AF13.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4331918.
    KEGGi osa:4331918.

    Organism-specific databases

    Gramenei A3AF13.

    Phylogenomic databases

    eggNOGi COG5077.
    KOi K11858.

    Family and domain databases

    Gene3Di 3.30.2230.10. 2 hits.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF06337. DUSP. 2 hits.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
      The rice chromosome 3 sequencing consortium
      Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
      , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
      Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    3. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    4. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiUBP26_ORYSJ
    AccessioniPrimary (citable) accession number: A3AF13
    Secondary accession number(s): Q0DUD1, Q10QK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3