ID CHS1_ORYSI Reviewed; 398 AA. AC A2ZEX7; P48405; P93710; Q9AVC2; DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-2007, sequence version 1. DT 27-MAR-2024, entry version 80. DE RecName: Full=Chalcone synthase 1; DE Short=OsCHS1; DE EC=2.3.1.74; DE AltName: Full=Naregenin-chalcone synthase; GN Name=CHS1; Synonyms=CHS; ORFNames=OsI_035120; OS Oryza sativa subsp. indica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39946; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=cv. Purple Puttu; TISSUE=Leaf; RA Scheffler B.E., Reddy A.R., Hoffmann I., Wienand U.; RT "Chalcone synthase cDNA from Oryza sativa."; RL (er) Plant Gene Register PGR95-071(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. 93-11; RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038; RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L., RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.; RT "The genomes of Oryza sativa: a history of duplications."; RL PLoS Biol. 3:266-281(2005). CC -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'- CC tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) CC which can under specific conditions spontaneously isomerize into CC naringenin. CC -!- CATALYTIC ACTIVITY: CC Reaction=4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'- CC tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57355, ChEBI:CHEBI:57384, ChEBI:CHEBI:77645; EC=2.3.1.74; CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10023}; CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis. CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene CC synthases family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X89859; CAA61955.1; -; mRNA. DR EMBL; CM000136; EAY81161.1; -; Genomic_DNA. DR PIR; S58190; S58190. DR PDB; 4YJY; X-ray; 1.86 A; A/B=1-398. DR PDBsum; 4YJY; -. DR AlphaFoldDB; A2ZEX7; -. DR SMR; A2ZEX7; -. DR STRING; 39946.A2ZEX7; -. DR EnsemblPlants; BGIOSGA033874-TA; BGIOSGA033874-PA; BGIOSGA033874. DR Gramene; BGIOSGA033874-TA; BGIOSGA033874-PA; BGIOSGA033874. DR HOGENOM; CLU_034992_2_0_1; -. DR OMA; PIWGLGC; -. DR UniPathway; UPA00154; -. DR Proteomes; UP000007015; Chromosome 11. DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC. DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC. DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd00831; CHS_like; 1. DR Gene3D; 3.40.47.10; -; 2. DR InterPro; IPR012328; Chalcone/stilbene_synt_C. DR InterPro; IPR001099; Chalcone/stilbene_synt_N. DR InterPro; IPR018088; Chalcone/stilbene_synthase_AS. DR InterPro; IPR011141; Polyketide_synthase_type-III. DR InterPro; IPR016039; Thiolase-like. DR PANTHER; PTHR11877:SF14; CHALCONE SYNTHASE; 1. DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1. DR Pfam; PF02797; Chal_sti_synt_C; 1. DR Pfam; PF00195; Chal_sti_synt_N; 1. DR PIRSF; PIRSF000451; PKS_III; 1. DR SUPFAM; SSF53901; Thiolase-like; 2. DR PROSITE; PS00441; CHALCONE_SYNTH; 1. PE 1: Evidence at protein level; KW 3D-structure; Acyltransferase; Flavonoid biosynthesis; Reference proteome; KW Transferase. FT CHAIN 1..398 FT /note="Chalcone synthase 1" FT /id="PRO_0000293085" FT ACT_SITE 167 FT /note="Acyl-thioester intermediate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10023" FT BINDING 58..65 FT /ligand="CoA" FT /ligand_id="ChEBI:CHEBI:57287" FT /evidence="ECO:0000250" FT BINDING 200 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 219..220 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 311 FT /ligand="CoA" FT /ligand_id="ChEBI:CHEBI:57287" FT /evidence="ECO:0000250" FT HELIX 7..14 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 21..28 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 33..35 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 36..38 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 39..46 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 53..65 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 70..72 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 77..82 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 84..86 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 88..90 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 94..120 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 124..126 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 129..136 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 143..151 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 158..164 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 169..182 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 188..195 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 197..199 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 209..217 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 221..230 FT /evidence="ECO:0007829|PDB:4YJY" FT TURN 233..235 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 240..249 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 256..262 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 265..270 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 274..290 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 291..293 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 298..300 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 301..305 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 310..320 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 324..327 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 328..337 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 341..343 FT /evidence="ECO:0007829|PDB:4YJY" FT HELIX 344..358 FT /evidence="ECO:0007829|PDB:4YJY" FT TURN 364..367 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 369..377 FT /evidence="ECO:0007829|PDB:4YJY" FT TURN 378..380 FT /evidence="ECO:0007829|PDB:4YJY" FT STRAND 381..389 FT /evidence="ECO:0007829|PDB:4YJY" SQ SEQUENCE 398 AA; 43238 MW; 583FC50C65BB9755 CRC64; MAAAVTVEEV RRAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFRITKSE HMVELKEKFK RMCDKSQIRK RYMHLTEEIL QENPNMCAYM APSLDARQDI VVVEVPKLGK AAAQKAIKEW GQPRSRITHL VFCTTSGVDM PGADYQLAKM LGLRPNVSRL MMYQQGCFAG GTVLRVAKDL AENNRGARVL AVCSEITAVT FRGPSESHLD SMVGQALFGD GAAAVIVGSD PDEAVERPLF QMVSASQTIL PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALGDAF TPLGISDWNS IFWVAHPGGP AILDQVEAKV GLDKERMRAT RHVLSEYGNM SSACVLFILD EMRKRSAEDG HATTGEGMDW GVLFGFGPGL TVETVVLHSV PITAGAAA //