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A2ZEX7 (CHS1_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 1

Short name=OsCHS1
EC=2.3.1.74
Alternative name(s):
Naregenin-chalcone synthase
Gene names
Name:CHS1
Synonyms:CHS
ORF Names:OsI_035120
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Chalcone synthase 1
PRO_0000293085

Regions

Region58 – 658Coenzyme A binding By similarity
Region219 – 2202Substrate binding By similarity

Sites

Active site1671Acyl-thioester intermediate By similarity
Binding site2001Substrate By similarity
Binding site3111Coenzyme A; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A2ZEX7 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 583FC50C65BB9755

FASTA39843,238
        10         20         30         40         50         60 
MAAAVTVEEV RRAQRAEGPA TVLAIGTATP ANCVYQADYP DYYFRITKSE HMVELKEKFK 

        70         80         90        100        110        120 
RMCDKSQIRK RYMHLTEEIL QENPNMCAYM APSLDARQDI VVVEVPKLGK AAAQKAIKEW 

       130        140        150        160        170        180 
GQPRSRITHL VFCTTSGVDM PGADYQLAKM LGLRPNVSRL MMYQQGCFAG GTVLRVAKDL 

       190        200        210        220        230        240 
AENNRGARVL AVCSEITAVT FRGPSESHLD SMVGQALFGD GAAAVIVGSD PDEAVERPLF 

       250        260        270        280        290        300 
QMVSASQTIL PDSEGAIDGH LREVGLTFHL LKDVPGLISK NIERALGDAF TPLGISDWNS 

       310        320        330        340        350        360 
IFWVAHPGGP AILDQVEAKV GLDKERMRAT RHVLSEYGNM SSACVLFILD EMRKRSAEDG 

       370        380        390 
HATTGEGMDW GVLFGFGPGL TVETVVLHSV PITAGAAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X89859 mRNA. Translation: CAA61955.1.
CM000136 Genomic DNA. Translation: EAY81161.1.
PIRS58190.
UniGeneOs.12416.

3D structure databases

ProteinModelPortalA2ZEX7.
SMRA2ZEX7. Positions 6-392.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os11g32650.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneA2ZEX7.

Phylogenomic databases

eggNOGCOG3424.
HOGENOMHOG000245460.

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS1_ORYSI
AccessionPrimary (citable) accession number: A2ZEX7
Secondary accession number(s): P48405, P93710, Q9AVC2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways