Reviewed, UniProtKB/Swiss-Prot A2Z212 (ABAH3_ORYSI)

Names and origin

Protein names

Recommended name:
    Abscisic acid 8'-hydroxylase 3
      Short name=ABA 8'-hydroxylase 3
    EC=1.14.13.93
Alternative name(s):
    OsABA8ox3
    Cytochrome P450 707A7

Gene names

Name:	CYP707A7
Synonyms:	ABA8OX3
ORF Names:	OsI_030605

Organism

Oryza sativa subsp. indica (Rice)

Taxonomic identifier

39946 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidative degradation of abscisic acid By similarity.
Catalytic activity	+-abscisate + NADPH + O2 = 8'-hydroxyabscisate + NADP+ + H2O.
Cofactor	Heme group By similarity.
Pathway	Plant hormone degradation; abscisic acid degradation.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	Heme Iron Metal-binding NADP
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	(+)-abscisic acid 8'-hydroxylase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Abscisic acid 8'-hydroxylase 3		PRO_0000288647
Regions
	Transmembrane	3 – 23	21	Potential
Sites
	Metal binding	426	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2Z212-1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: F14F3A706C2AF489	FASTA	500	56,158
	10 20 30 40 50 60 MAASFVIVIV ISFFISLAFM CYVHYTSRQR RKLHGYGHEK AVRLPPGSMG WPYIGETLQL 70 80 90 100 110 120 YSQDPNVFFA SKQKRYGEIF KTHILGCPCV MLASPEAARF VLVTQAHLFK PTYPRSKERM 130 140 150 160 170 180 IGPSALFFNQ GDYHLRLRKL VQGPLGPDAL RALVPDVEAA VRSTLASWDG NVSSTFHAMK 190 200 210 220 230 240 RLSFDVGIVT IFGGRLDERR KAELRQNYAI VEKGYNSFPN SFPGTLYYKA IQARRRLHGV 250 260 270 280 290 300 LSDIMRERRA RGEPGSDLLG CLMQSRAGDD GALLTDEQVA DNIIGVLFAA QDTTASVLTW 310 320 330 340 350 360 IVKYLHDHPK LLEAVRAEQA AIRAANDGGR LPLTWAQTRS MALTHKVILE SLRMASIISF 370 380 390 400 410 420 TFREAVADVE YKGFLIPKGW KVMPLFRNIH HNPDYFQDPQ KFDPSRFKVS PRPNTFMPFG 430 440 450 460 470 480 NGVHACPGNE LAKLEMLVLI HHLVTGYRWE IVGSSDEVEY SPFPVPKHGL LAKLWRDDTV 490 500 SVETDGCQNG DNDDNGVAMV

References

[1]

"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. 93-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CM000134 Genomic DNA. Translation: EAZ09373.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABAH3_ORYSI

Accession

Primary (citable) accession number: A2Z212

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 20, 2007
Last modified:	March 24, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)