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A2YXU2 (PSA7A_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-7-A

EC=3.4.25.1
Alternative name(s):
20S proteasome alpha subunit D-1
20S proteasome subunit alpha-4-A
Gene names
ORF Names:OsI_029135
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Proteasome subunit alpha type-7-A
PRO_0000301663

Sequences

Sequence LengthMass (Da)Tools
A2YXU2 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: D6F10209082B4797

FASTA24927,296
        10         20         30         40         50         60 
MARYDRAITV FSPDGHLFQV EYALEAVRKG NAAVGVRGTD TVVLGVEKKS TPKLQDSRSM 

        70         80         90        100        110        120 
RKIASLDTHI ALACAGLKAD ARVLINRARV ECQSHRLTVE DPVTVEYITR YIAGLQQKYT 

       130        140        150        160        170        180 
QSGGVRPFGL STLIVGFDPY TEKPALYQTD PSGTFSAWKA NATGRNSNSM REFLEKNYKD 

       190        200        210        220        230        240 
TSGKETIKLA IRALLEVVES GGKNIEIAVM THKDGLRELE EAEIDEYVAE IEAEKAAAEA 


AKKGAPKET 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92540 mRNA. Translation: AAB51521.1.
CM000133 Genomic DNA. No translation available.
PIRT04300.
UniGeneOs.3737.

3D structure databases

ProteinModelPortalA2YXU2.
SMRA2YXU2. Positions 4-231.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2YXU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneA2YXU2.

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000091085.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA7A_ORYSI
AccessionPrimary (citable) accession number: A2YXU2
Secondary accession number(s): O04861, Q69JF0, Q9LRI3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries