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Protein

Zinc-finger homeodomain protein 2

Gene

ZHD2

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative transcription factor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei278Required for DNA-bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 112ZF-HD dimerization-type; degeneratePROSITE-ProRule annotationAdd BLAST50
DNA bindingi226 – 289HomeoboxAdd BLAST64

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-finger homeodomain protein 2
Gene namesi
Name:ZHD2
ORF Names:OsI_29618
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000007015 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004260381 – 290Zinc-finger homeodomain protein 2Add BLAST290

Interactioni

Subunit structurei

Homo- and heterodimer with other ZFHD proteins.By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA026798-PA.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 92Gly-richAdd BLAST62
Compositional biasi162 – 173Ala-richAdd BLAST12

Domaini

The homeodomain differs form the typical one by having namely 4 instead of 3 extra amino acids inserted in the loop between helix 1 and helix 2.

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.Curated
Contains 1 ZF-HD dimerization-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 112ZF-HD dimerization-type; degeneratePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Homeobox, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IX1N. Eukaryota.
ENOG410YEN7. LUCA.
HOGENOMiHOG000238105.
OMAiGTRYREC.
OrthoDBiEOG09360PCW.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006455. Homeodomain_ZF_HD.
IPR006456. ZF_HD_homeobox_Cys/His_dimer.
[Graphical view]
PfamiPF04770. ZF-HD_dimer. 1 hit.
[Graphical view]
ProDomiPD125774. ZF_HD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR01565. homeo_ZF_HD. 1 hit.
TIGR01566. ZF_HD_prot_N. 1 hit.
PROSITEiPS51523. ZF_HD_DIMER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2YWA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFDDHDEGD GDEEMPPMPL SSGYDAPMQP GLGGGGGGVP KPGGGVGGGG
60 70 80 90 100
GGGGGGGGGG ARYRECLKNH AVGIGGHAVD GCGEFMASGE EGSIDALRCA
110 120 130 140 150
ACGCHRNFHR KESESPTGVG PAEPSAVSPA AISAYGASPH HQFSPYYRTP
160 170 180 190 200
AGYLHHQQHQ MAAAAAAAAA AAAGGYPQRP LALPSTSHSG RDEGDDMSGM
210 220 230 240 250
VGPMVIGPMV GMSLGSAGPS GSGSGKKRFR TKFTQEQKDK MLAFAERLGW
260 270 280 290
RIQKHDEAAV QQFCEEVCVK RHVLKVWMHN NKHTLGKKAP
Length:290
Mass (Da):29,759
Last modified:March 20, 2007 - v1
Checksum:i0BD54AA162DDE05A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000133 Genomic DNA. Translation: EAZ07367.1.

Genome annotation databases

EnsemblPlantsiBGIOSGA026798-TA; BGIOSGA026798-PA; BGIOSGA026798.
GrameneiBGIOSGA026798-TA; BGIOSGA026798-PA; BGIOSGA026798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000133 Genomic DNA. Translation: EAZ07367.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA026798-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBGIOSGA026798-TA; BGIOSGA026798-PA; BGIOSGA026798.
GrameneiBGIOSGA026798-TA; BGIOSGA026798-PA; BGIOSGA026798.

Phylogenomic databases

eggNOGiENOG410IX1N. Eukaryota.
ENOG410YEN7. LUCA.
HOGENOMiHOG000238105.
OMAiGTRYREC.
OrthoDBiEOG09360PCW.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR006455. Homeodomain_ZF_HD.
IPR006456. ZF_HD_homeobox_Cys/His_dimer.
[Graphical view]
PfamiPF04770. ZF-HD_dimer. 1 hit.
[Graphical view]
ProDomiPD125774. ZF_HD_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR01565. homeo_ZF_HD. 1 hit.
TIGR01566. ZF_HD_prot_N. 1 hit.
PROSITEiPS51523. ZF_HD_DIMER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZHD2_ORYSI
AccessioniPrimary (citable) accession number: A2YWA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.