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A2YVR7 (PSA2_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-2

EC=3.4.25.1
Alternative name(s):
20S proteasome alpha subunit B
20S proteasome subunit alpha-2
Gene names
Name:PAB1
ORF Names:OsI_028410
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence caution

The sequence AAB82138.1 differs from that shown. Reason: Frameshift at position 229.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Proteasome subunit alpha type-2
PRO_0000301662

Experimental info

Sequence conflict231E → N in AAB82138. Ref.1
Sequence conflict45 – 462VI → FV in AAB82138. Ref.1
Sequence conflict721I → V in AAB82138. Ref.1
Sequence conflict911R → P in AAB82138. Ref.1
Sequence conflict97 – 982YY → CC in AAB82138. Ref.1
Sequence conflict1051I → M in AAB82138. Ref.1
Sequence conflict1781Y → H in AAB82138. Ref.1
Sequence conflict1911A → G in AAB82138. Ref.1
Sequence conflict1941T → I in AAB82138. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A2YVR7 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: D98998C0BC6CD676

FASTA23525,844
        10         20         30         40         50         60 
MGDSQYSFSL TTFSPSGKLV QIEHALTAVG SGQTSLGIKA ANGVVIATEK KLPSILVDET 

        70         80         90        100        110        120 
SVQKIQSLTP NIGVVYSGMG PDFRVLVRKS RKQAQQYYRL YKETIPVTQL VRETAAVMQE 

       130        140        150        160        170        180 
FTQSGGVRPF GVSLLIAGYD DNGPQLYQVD PSGSYFSWKA SAMGKNVSNA KTFLEKRYTE 

       190        200        210        220        230 
DMELDDAIHT AILTLKEGYE GQISANNIEI GIIRSDREFK VLSPAEIKDF LEEVE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022735 mRNA. Translation: AAB82138.1. Frameshift.
CM000133 Genomic DNA. No translation available.
PIRT02089.
UniGeneOs.7900.

3D structure databases

ProteinModelPortalA2YVR7.
SMRA2YVR7. Positions 6-234.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING39947.LOC_Os03g26970.1.

Proteomic databases

PRIDEA2YVR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneA2YVR7.

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000091085.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA2_ORYSI
AccessionPrimary (citable) accession number: A2YVR7
Secondary accession number(s): O22539, Q6AVF6, Q9LSU2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries