Reviewed, UniProtKB/Swiss-Prot A2YPT7 (CARM1_ORYSI)

Names and origin

Protein names

Recommended name:
    Probable histone-arginine methyltransferase CARM1
    EC=2.1.1.125
    EC=2.1.1.-
Alternative name(s):
    Protein arginine N-methyltransferase 4

Gene names

Name:	CARM1
Synonyms:	PRMT4
ORF Names:	OsI_27289

Organism

Oryza sativa subsp. indica (Rice)

Taxonomic identifier

39946 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation, methylates histone H3 and activates transcription via chromatin remodeling By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-arginine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 528	528	Probable histone-arginine methyltransferase CARM1		PRO_0000294006
Regions
	Compositional bias	496 – 517	22	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	A2YPT7-1 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: 06043252B82901AD	FASTA	528	58,580
	10 20 30 40 50 60 MASPDLFPNV SFSHVSVPAA AGASTEVTGG ATAVFGGDAS TGAPRLSLVW SGETQAKHTL 70 80 90 100 110 120 EIDLSDAQIF KLGPTEWLCV SGESEAKDGV EEKSYSRAIK VVLRTEAESK AFYLAFQQWK 130 140 150 160 170 180 HRVISGKAGE PLENGLIIGS KSKFDTKIEA SSAKMYFHYY GQLLHQQNML QDFVRTGTYY 190 200 210 220 230 240 AAVMENRSDF EGRVVVDVGA GSGILSLFAA QAGARHVYAV EASEMAEHAQ RLISGNPSLG 250 260 270 280 290 300 QRITVIKGKV EEVELPEKAD ILISEPMGTL LVNERMLESY VIARDRFLVP GGKMFPTTGR 310 320 330 340 350 360 IHMAPFSDEY LYVEMANKAL FWQQHNFFGV DLTPLHGSAF QGYFSQPVVD AFDPRLLVSP 370 380 390 400 410 420 PTFHTLDFTT MKEEELYEID IPLNFVASVG TRVHGLACWF DVLFNGSTVQ RWLTTAPGSP 430 440 450 460 470 480 TTHWYQLRCI LSQPLYVMAG QEITGRLHLV AHSAQSYTIY LTMSAKMWGE GAEQGGILQT 490 500 510 520 STAKLELKEP YYRLSQPQPY VMQQDQQQQQ LPSLQPQSPL WDYHYGQD

References

[1]

"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. 93-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CM000132 Genomic DNA. Translation: EEC82664.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR007848. Small_mtfrase. [Graphical view]
Pfam	PF05175. MTS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CARM1_ORYSI

Accession

Primary (citable) accession number: A2YPT7
Secondary accession number(s): B8B5U5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	October 13, 2009
This is version 15 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)