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A2YEB4 (PP2A1_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

EC=3.1.3.16
Gene names
Name:PP2A1
ORF Names:OsI_022657
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-2A subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
Gene Ontology (GO)
   Biological_processcellular protein localization

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

chloroplast avoidance movement

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

protein dephosphorylation

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

regulation of auxin polar transport

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentcytosol

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

nucleus

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

plasma membrane

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
PRO_0000301655

Sites

Active site1151Proton donor By similarity
Metal binding541Manganese 1 By similarity
Metal binding561Manganese 1 By similarity
Metal binding821Manganese 1 By similarity
Metal binding821Manganese 2 By similarity
Metal binding1141Manganese 2 By similarity
Metal binding1641Manganese 2 By similarity
Metal binding2381Manganese 2 By similarity

Experimental info

Sequence conflict471C → S in AAA91806. Ref.1
Sequence conflict691G → A in AAC72838. Ref.2
Sequence conflict1061D → E in AAA91806. Ref.1
Sequence conflict1441T → A in AAA91806. Ref.1
Sequence conflict2171F → N in AAA91806. Ref.1
Sequence conflict2941E → D in AAA91806. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A2YEB4 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: F95722F8A638FF31

FASTA30635,114
        10         20         30         40         50         60 
MPSHADLDRQ ISQLRECKFL GEAEVRALCE QAKAILMEEW NVQPVRCPVT VCGDIHGQFY 

        70         80         90        100        110        120 
DLIELFRIGG DSPDTNYLFM GDYVDRGYYS VETVTLLVAL KVRYRDRITI LRGNHESRQI 

       130        140        150        160        170        180 
TQVYGFYDEC LRKYGNANVW KYFTDLFDYL PLTALVENQV FCLHGGLSPS LDTLDNIRAL 

       190        200        210        220        230        240 
DRIQEVPHEG PMCDLLWSDP DDRCGWGISP RGAGYTFGQD IAQQFNHTNG LTLISRAHQL 

       250        260        270        280        290        300 
VMEGFNWCQD KNVVTVFSAP NYCYRCGNMA AILEIGENMD QNFLQFDPAP RQIEPDTTRK 


TPDYFL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of catalytic-subunit cDNA sequences encoding protein phosphatases 1 and 2A and study of their roles in the gibberellin-dependent Osamy-c expression in rice."
Chang M., Wang B., Chen X., Wu R.
Plant Mol. Biol. 39:105-115(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. IR36.
Tissue: Seed.
[2]"Two genes encoding protein phosphatase 2A catalytic subunits are differentially expressed in rice."
Yu R.M.K., Zhou Y., Xu Z.-F., Chye M.-L., Kong R.Y.
Plant Mol. Biol. 51:295-311(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. IR36.
[3]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. 93-11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49113 mRNA. Translation: AAA91806.1.
AF097182 Genomic DNA. Translation: AAC72838.1.
CM000131 Genomic DNA. Translation: EAZ01425.1.
PIRT03389.
UniGeneOs.49858.

3D structure databases

ProteinModelPortalA2YEB4.
SMRA2YEB4. Positions 6-306.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA2YEB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneA2YEB4.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP2A1_ORYSI
AccessionPrimary (citable) accession number: A2YEB4
Secondary accession number(s): Q42981, Q5Z7K2, Q9ZSS3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families