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Protein

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene

PP2A1

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Manganese 1By similarity
Metal bindingi56 – 561Manganese 1By similarity
Metal bindingi82 – 821Manganese 1By similarity
Metal bindingi82 – 821Manganese 2By similarity
Metal bindingi114 – 1141Manganese 2By similarity
Active sitei115 – 1151Proton donorBy similarity
Metal bindingi164 – 1641Manganese 2By similarity
Metal bindingi238 – 2381Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A1
ORF Names:OsI_022657
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
ProteomesiUP000007015 Componenti: Chromosome 6

Organism-specific databases

GrameneiA2YEB4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Serine/threonine-protein phosphatase PP2A-1 catalytic subunitPRO_0000301655Add
BLAST

Proteomic databases

PRIDEiA2YEB4.

Interactioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA023128-PA.

Structurei

3D structure databases

ProteinModelPortaliA2YEB4.
SMRiA2YEB4. Positions 6-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
OMAiGVECAAS.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2YEB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSHADLDRQ ISQLRECKFL GEAEVRALCE QAKAILMEEW NVQPVRCPVT
60 70 80 90 100
VCGDIHGQFY DLIELFRIGG DSPDTNYLFM GDYVDRGYYS VETVTLLVAL
110 120 130 140 150
KVRYRDRITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW KYFTDLFDYL
160 170 180 190 200
PLTALVENQV FCLHGGLSPS LDTLDNIRAL DRIQEVPHEG PMCDLLWSDP
210 220 230 240 250
DDRCGWGISP RGAGYTFGQD IAQQFNHTNG LTLISRAHQL VMEGFNWCQD
260 270 280 290 300
KNVVTVFSAP NYCYRCGNMA AILEIGENMD QNFLQFDPAP RQIEPDTTRK

TPDYFL
Length:306
Mass (Da):35,114
Last modified:March 20, 2007 - v1
Checksum:iF95722F8A638FF31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471C → S in AAA91806 (PubMed:10080713).Curated
Sequence conflicti69 – 691G → A in AAC72838 (PubMed:12602862).Curated
Sequence conflicti106 – 1061D → E in AAA91806 (PubMed:10080713).Curated
Sequence conflicti144 – 1441T → A in AAA91806 (PubMed:10080713).Curated
Sequence conflicti217 – 2171F → N in AAA91806 (PubMed:10080713).Curated
Sequence conflicti294 – 2941E → D in AAA91806 (PubMed:10080713).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49113 mRNA. Translation: AAA91806.1.
AF097182 Genomic DNA. Translation: AAC72838.1.
CM000131 Genomic DNA. Translation: EAZ01425.1.
PIRiT03389.
UniGeneiOs.49858.

Genome annotation databases

EnsemblPlantsiBGIOSGA023128-TA; BGIOSGA023128-PA; BGIOSGA023128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49113 mRNA. Translation: AAA91806.1.
AF097182 Genomic DNA. Translation: AAC72838.1.
CM000131 Genomic DNA. Translation: EAZ01425.1.
PIRiT03389.
UniGeneiOs.49858.

3D structure databases

ProteinModelPortaliA2YEB4.
SMRiA2YEB4. Positions 6-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA023128-PA.

Proteomic databases

PRIDEiA2YEB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBGIOSGA023128-TA; BGIOSGA023128-PA; BGIOSGA023128.

Organism-specific databases

GrameneiA2YEB4.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
OMAiGVECAAS.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of catalytic-subunit cDNA sequences encoding protein phosphatases 1 and 2A and study of their roles in the gibberellin-dependent Osamy-c expression in rice."
    Chang M., Wang B., Chen X., Wu R.
    Plant Mol. Biol. 39:105-115(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. IR36.
    Tissue: Seed.
  2. "Two genes encoding protein phosphatase 2A catalytic subunits are differentially expressed in rice."
    Yu R.M.K., Zhou Y., Xu Z.-F., Chye M.-L., Kong R.Y.
    Plant Mol. Biol. 51:295-311(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. IR36.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.

Entry informationi

Entry nameiPP2A1_ORYSI
AccessioniPrimary (citable) accession number: A2YEB4
Secondary accession number(s): Q42981, Q5Z7K2, Q9ZSS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.