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Protein

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

Gene

PP2A1

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Manganese 1By similarity1
Metal bindingi56Manganese 1By similarity1
Metal bindingi82Manganese 1By similarity1
Metal bindingi82Manganese 2By similarity1
Metal bindingi114Manganese 2By similarity1
Active sitei115Proton donorBy similarity1
Metal bindingi164Manganese 2By similarity1
Metal bindingi238Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit (EC:3.1.3.16)
Gene namesi
Name:PP2A1
ORF Names:OsI_022657
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003016551 – 306Serine/threonine-protein phosphatase PP2A-1 catalytic subunitAdd BLAST306

Interactioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA023128-PA.

Structurei

3D structure databases

ProteinModelPortaliA2YEB4.
SMRiA2YEB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2A subfamily.Curated

Phylogenomic databases

eggNOGiKOG0371. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000172696.
OMAiIARAHQI.
OrthoDBiEOG09360EXD.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiView protein in SMART
SM00156. PP2Ac. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS00125. SER_THR_PHOSPHATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A2YEB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSHADLDRQ ISQLRECKFL GEAEVRALCE QAKAILMEEW NVQPVRCPVT
60 70 80 90 100
VCGDIHGQFY DLIELFRIGG DSPDTNYLFM GDYVDRGYYS VETVTLLVAL
110 120 130 140 150
KVRYRDRITI LRGNHESRQI TQVYGFYDEC LRKYGNANVW KYFTDLFDYL
160 170 180 190 200
PLTALVENQV FCLHGGLSPS LDTLDNIRAL DRIQEVPHEG PMCDLLWSDP
210 220 230 240 250
DDRCGWGISP RGAGYTFGQD IAQQFNHTNG LTLISRAHQL VMEGFNWCQD
260 270 280 290 300
KNVVTVFSAP NYCYRCGNMA AILEIGENMD QNFLQFDPAP RQIEPDTTRK

TPDYFL
Length:306
Mass (Da):35,114
Last modified:March 20, 2007 - v1
Checksum:iF95722F8A638FF31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47C → S in AAA91806 (PubMed:10080713).Curated1
Sequence conflicti69G → A in AAC72838 (PubMed:12602862).Curated1
Sequence conflicti106D → E in AAA91806 (PubMed:10080713).Curated1
Sequence conflicti144T → A in AAA91806 (PubMed:10080713).Curated1
Sequence conflicti217F → N in AAA91806 (PubMed:10080713).Curated1
Sequence conflicti294E → D in AAA91806 (PubMed:10080713).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49113 mRNA. Translation: AAA91806.1.
AF097182 Genomic DNA. Translation: AAC72838.1.
CM000131 Genomic DNA. Translation: EAZ01425.1.
PIRiT03389.

Genome annotation databases

EnsemblPlantsiBGIOSGA023128-TA; BGIOSGA023128-PA; BGIOSGA023128.
OS06T0574500-01; OS06T0574500-01; OS06G0574500.
GrameneiBGIOSGA023128-TA; BGIOSGA023128-PA; BGIOSGA023128.
OS06T0574500-01; OS06T0574500-01; OS06G0574500.

Similar proteinsi

Entry informationi

Entry nameiPP2A1_ORYSI
AccessioniPrimary (citable) accession number: A2YEB4
Secondary accession number(s): Q42981, Q5Z7K2, Q9ZSS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 20, 2007
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families