Reviewed, UniProtKB/Swiss-Prot A2Y0X2 (CESA1_ORYSI)

Names and origin

Protein names

Recommended name:
    Probable cellulose synthase A catalytic subunit 1 [UDP-forming]
    EC=2.4.1.12
Alternative name(s):
    OsCesA1

Gene names

Name:	CESA1
ORF Names:	OsI_017965

Organism

Oryza sativa subsp. indica (Rice)

Taxonomic identifier

39946 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	1076 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation By similarity.
Catalytic activity	UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Glycan metabolism; plant cellulose biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation Cellulose biosynthesis
Cellular component	Cell membrane Membrane
Domain	Coiled coil Transmembrane Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1076	1076	Probable cellulose synthase A catalytic subunit 1 [UDP-forming]		PRO_0000319357
Regions
	Topological domain	1 – 267	267	Cytoplasmic Potential
	Transmembrane	268 – 288	21	Potential
	Topological domain	289 – 296	8	Extracellular Potential
	Transmembrane	297 – 317	21	Potential
	Topological domain	318 – 851	534	Cytoplasmic Potential
	Transmembrane	852 – 872	21	Potential
	Topological domain	873 – 884	12	Extracellular Potential
	Transmembrane	885 – 905	21	Potential
	Topological domain	906 – 920	15	Cytoplasmic Potential
	Transmembrane	921 – 941	21	Potential
	Topological domain	942 – 971	30	Extracellular Potential
	Transmembrane	972 – 992	21	Potential
	Topological domain	993 – 1003	11	Cytoplasmic Potential
	Transmembrane	1004 – 1024	21	Potential
	Topological domain	1025 – 1033	9	Extracellular Potential
	Transmembrane	1034 – 1054	21	Potential
	Topological domain	1055 – 1076	22	Cytoplasmic Potential
	Zinc finger	41 – 87	47	RING-type; degenerate
	Coiled coil	446 – 473	28	Potential
Sites
	Active site	392	1	Potential
	Active site	775	1	Potential
	Metal binding	41	1	Zinc 1 By similarity
	Metal binding	44	1	Zinc 1 By similarity
	Metal binding	60	1	Zinc 2 By similarity
	Metal binding	63	1	Zinc 2 By similarity
	Metal binding	68	1	Zinc 1 By similarity
	Metal binding	71	1	Zinc 1 By similarity
	Metal binding	83	1	Zinc 2 By similarity
	Metal binding	86	1	Zinc 2 By similarity
	Binding site	558	1	Substrate Potential
	Binding site	560	1	Substrate Potential
Amino acid modifications
	Glycosylation	948	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A2Y0X2-1 [UniParc]. Last modified March 20, 2007. Version 1. Checksum: 6B40F19DAEDF1AEC	FASTA	1,076	121,268
	10 20 30 40 50 60 MAANAGMVAG SRNRNEFVMI RPDGDAPPPA KPGKSVNGQV CQICGDTVGV SATGDVFVAC 70 80 90 100 110 120 NECAFPVCRP CYEYERKEGN QCCPQCKTRY KRHKGSPRVQ GDEEEEDVDD LDNEFNYKHG 130 140 150 160 170 180 NGKGPEWQIQ RQGEDVDLSS SSRHEQHRIP RLTSGQQISG EIPDASPDRH SIRSGTSSYV 190 200 210 220 230 240 DPSVPVPVRI VDPSKDLNSY GINSVDWQER VASWRNKQDK NMMQVANKYP EARGGDMEGT 250 260 270 280 290 300 GSNGEDMQMV DDARLPLSRI VPIPSNQLNL YRIVIILRLI ILMFFFQYRV THPVRDAYGL 310 320 330 340 350 360 WLVSVICEIW FALSWLLDQF PKWYPINRET YLDRLALRYD REGEPSQLAP IDVFVSTVDP 370 380 390 400 410 420 LKEPPLITAN TVLSILAVDY PVDKVSCYVS DDGSAMLTFE ALSETAEFAR KWVPFCKKHN 430 440 450 460 470 480 IEPRAPEFYF AQKIDYLKDK IQPSFVKERR AMKREYEEFK VRINALVAKA QKVPEEGWTM 490 500 510 520 530 540 ADGTAWPGNN PRDHPGMIQV FLGHSGGLDT DGNELPRLVY VSREKRPGFQ HHKKAGAMNA 550 560 570 580 590 600 LIRVSAVLTN GAYLLNVDCD HYFNSSKALR EAMCFMMDPA LGRKTCYVQF PQRFDGIDLH 610 620 630 640 650 660 DRYANRNIVF FDINMKGLDG IQGPVYVGTG CCFNRQALYG YDPVLTEADL EPNIVVKSCC 670 680 690 700 710 720 GGRKKKSKSY MDSKNRMMKR TESSAPIFNM EDIEEGIEGY EDERSVLMSQ KRLEKRFGQS 730 740 750 760 770 780 PIFIASTFMT QGGIPPSTNP ASLLKEAIHV ISCGYEDKTE WGKEIGWIYG SVTEDILTGF 790 800 810 820 830 840 KMHARGWISI YCMPPRPCFK GSAPINLSDR LNQVLRWALG SVEILLSRHC PIWYGYNGRL 850 860 870 880 890 900 KLLERLAYIN TIVYPITSIP LIAYCVLPAI CLLTNKFIIP EISNYAGMFF ILLFASIFAT 910 920 930 940 950 960 GILELRWSGV GIEDWWRNEQ FWVIGGTSAH LFAVFQGLLK VLAGIDTNFT VTSKASDEDG 970 980 990 1000 1010 1020 DFAELYVFKW TSLLIPPTTV LVINLVGMVA GISYAINSGY QSWGPLFGKL FFSIWVILHL 1030 1040 1050 1060 1070 YPFLKGLMGR QNRTPTIVIV WSILLASIFS LLWVKIDPFI SPTQKAVALG QCGVNC

References

[1]

"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. 93-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CM000130 Genomic DNA. Translation: EAY96732.1.
3D structure databases
SMR	A2Y0X2. Positions 31-99.
ModBase	Search...
Family and domain databases
InterPro	IPR005150. Cellulose_synth. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF03552. Cellulose_synt. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CESA1_ORYSI

Accession

Primary (citable) accession number: A2Y0X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 20, 2007
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)