ID   RPAP2_ORYSI             Reviewed;         726 AA.
AC   A2Y040;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog;
DE            EC=3.1.3.16;
DE   AltName: Full=RNA polymerase II-associated protein 2 homolog;
GN   ORFNames=OsI_18345;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Putative RNA polymerase II subunit B1 C-terminal domain (CTD)
CC       phosphatase involved in RNA polymerase II transcription regulation.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RPAP2 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00812, ECO:0000305}.
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DR   EMBL; CM000130; EAY96450.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2Y040; -.
DR   SMR; A2Y040; -.
DR   STRING; 39946.A2Y040; -.
DR   EnsemblPlants; BGIOSGA018860-TA; BGIOSGA018860-PA; BGIOSGA018860.
DR   Gramene; BGIOSGA018860-TA; BGIOSGA018860-PA; BGIOSGA018860.
DR   HOGENOM; CLU_008740_0_0_1; -.
DR   OMA; ACGYPAC; -.
DR   Proteomes; UP000007015; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblPlants.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0043175; F:RNA polymerase core enzyme binding; IEA:InterPro.
DR   GO; GO:0008420; F:RNA polymerase II CTD heptapeptide repeat phosphatase activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:EnsemblPlants.
DR   Gene3D; 1.25.40.820; -; 1.
DR   InterPro; IPR039693; Rtr1/RPAP2.
DR   InterPro; IPR007308; Rtr1/RPAP2_dom.
DR   InterPro; IPR038534; Rtr1/RPAP2_sf.
DR   PANTHER; PTHR14732:SF0; RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED; 1.
DR   PANTHER; PTHR14732; UNCHARACTERIZED; 1.
DR   Pfam; PF04181; RPAP2_Rtr1; 1.
DR   PROSITE; PS51479; ZF_RTR1; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Nucleus; Protein phosphatase; Reference proteome;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..726
FT                   /note="Putative RNA polymerase II subunit B1 CTD
FT                   phosphatase RPAP2 homolog"
FT                   /id="PRO_0000416293"
FT   ZN_FING         43..131
FT                   /note="RTR1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00812"
FT   REGION          209..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          294..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00812"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00812"
FT   BINDING         107
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00812"
FT   BINDING         111
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00812"
SQ   SEQUENCE   726 AA;  78243 MW;  196556A6DD98BC51 CRC64;
     MGPTTATDAG ARMKPTTVAS AVHRVQMALY DGAAASREPL LRAAASLLSG PDYADVVTER
     SIADACGYPA CPNPLPSEDA RGKAAPRFRI SLREHRVYDL EEARKFCSER CLVASAAFGA
     SLPPDRPFGV SPDRLDALVA LFEGGGGGGG DGGLALGFGA SGDGKEVEEG RKVEIMEKEA
     AGTGEVTLQE WIGPSDAIEG YVPRRDRVVG GPKKEAKQND ACSAEQSSNI NVDSRNASSG
     ESGMVLTENT KAKKKEATKT PLKMFKQDED NDMLSSCISD SIVKQLEDVV LEEKKDKKKN
     KAAKGTSRVG KSKPAKRPVG RDGHEVDFTS TIIMGDHGSE MMDHGALGQY NFSSSILANE
     QPSSSQYAAI DSVQAYTEEL DELFSNAVNI AKDETSDDSG RCTLRSSLKA VGSKNAGRSV
     KWADENGSVL ETSRAFVSHS SKSQESMDSS VRRESAEACA AALIEAAEAI SSGTSEVEDA
     VSKAGIIILP DMVNQQQYNN DYDNDKDAGE NEIFEIDRGV VKWPKKTVLL DTDMFDVDDS
     WHDTPPEGFS LTLSSFATMW AALFGWVSRS SLAYVYGLDE SSMEDLLIAG GRECPQKRVL
     NDGHSSEIRR ALDTCVCNAL PVLVSNLRMQ IPVSKLEITL GYLLDTMSFV DALPSLRSRQ
     WQLMVLVLLD ALSLHRLPAL APIMSDSKLL QKLLNSAQVS REEYDSMIDL LLPFGRSTQS
     QASLPS
//