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Protein

Probable glutathione S-transferase GSTU1

Gene

GSTU1

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15GlutathioneBy similarity1
Binding sitei42GlutathioneBy similarity1
Binding sitei56Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase GSTU1 (EC:2.5.1.18)
Gene namesi
Name:GSTU1
Synonyms:GST1
ORF Names:OsI_013325
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000007015 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956531 – 231Probable glutathione S-transferase GSTU1Add BLAST231

Interactioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA009694-PA.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi16 – 28Combined sources13
Beta strandi33 – 36Combined sources4
Helixi44 – 49Combined sources6
Turni51 – 53Combined sources3
Beta strandi58 – 61Combined sources4
Beta strandi64 – 68Combined sources5
Helixi69 – 79Combined sources11
Helixi97 – 120Combined sources24
Helixi127 – 148Combined sources22
Beta strandi154 – 161Combined sources8
Helixi164 – 169Combined sources6
Helixi170 – 174Combined sources5
Helixi176 – 183Combined sources8
Helixi187 – 190Combined sources4
Helixi192 – 201Combined sources10
Helixi205 – 210Combined sources6
Helixi214 – 223Combined sources10
Turni224 – 226Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OYJX-ray1.95A/B/C/D1-231[»]
ProteinModelPortaliA2XMN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 84GST N-terminalAdd BLAST80
Domaini97 – 220GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 69Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
OMAiKGEPQAQ.
OrthoDBiEOG09360PCQ.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2XMN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEKELVLL DFWVSPFGQR CRIAMAEKGL EFEYREEDLG NKSDLLLRSN
60 70 80 90 100
PVHRKIPVLL HAGRPVSESL VILQYLDDAF PGTPHLLSPA NSGDADAAYA
110 120 130 140 150
RATARFWADY VDRKLYDCGS RLWRLKGEPQ AAAGREMAEI LRTLEAELGD
160 170 180 190 200
REFFGGGGGG RLGFVDVALV PFTAWFYSYE RCGGFSVEEV APRLAAWARR
210 220 230
CGRIDSVAKH LPSPEKVYDF VGVLKKKYGV E
Length:231
Mass (Da):25,832
Last modified:March 20, 2007 - v1
Checksum:i42C953E8F540DAB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88S → P in AAC05216 (Ref. 1) Curated1
Sequence conflicti90A → G in AAC05216 (Ref. 1) Curated1
Sequence conflicti99Y → F in AAC05216 (Ref. 1) Curated1
Sequence conflicti130Q → H in AAC05216 (Ref. 1) Curated1
Sequence conflicti175 – 179WFYSY → CSTAT in AAC05216 (Ref. 1) Curated5
Sequence conflicti201C → R in AAC05216 (Ref. 1) Curated1
Sequence conflicti208A → V in AAC05216 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050102 mRNA. Translation: AAC05216.1.
CM000128 Genomic DNA. Translation: EAY92092.1.
PIRiT02765.

Genome annotation databases

EnsemblPlantsiBGIOSGA009694-TA; BGIOSGA009694-PA; BGIOSGA009694.
GrameneiBGIOSGA009694-TA; BGIOSGA009694-PA; BGIOSGA009694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050102 mRNA. Translation: AAC05216.1.
CM000128 Genomic DNA. Translation: EAY92092.1.
PIRiT02765.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OYJX-ray1.95A/B/C/D1-231[»]
ProteinModelPortaliA2XMN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA009694-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBGIOSGA009694-TA; BGIOSGA009694-PA; BGIOSGA009694.
GrameneiBGIOSGA009694-TA; BGIOSGA009694-PA; BGIOSGA009694.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
OMAiKGEPQAQ.
OrthoDBiEOG09360PCQ.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTU1_ORYSI
AccessioniPrimary (citable) accession number: A2XMN2
Secondary accession number(s): O65032
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 20, 2007
Last modified: October 5, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.