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A2XDG4

- UBP26_ORYSI

UniProt

A2XDG4 - UBP26_ORYSI

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Protein
Ubiquitin carboxyl-terminal hydrolase 26
Gene
UBP26, OsI_010107
Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151Nucleophile By similarity
Active sitei359 – 3591Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. seed development Source: EnsemblPlants/Gramene
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A35.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:UBP26
ORF Names:OsI_010107
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiA2XDG4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleolus Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10791079Ubiquitin carboxyl-terminal hydrolase 26
PRO_0000293493Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA2XDG4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 446341USP
Add
BLAST
Domaini495 – 598104DUSP 1
Add
BLAST
Domaini613 – 715103DUSP 2
Add
BLAST
Domaini738 – 862125DUSP 3
Add
BLAST
Domaini961 – 103777Ubiquitin-like
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 3 DUSP domains.
Contains 1 USP domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000070740.

Family and domain databases

Gene3Di3.30.2230.10. 2 hits.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2XDG4-1 [UniParc]FASTAAdd to Basket

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MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC     50
HGCHGNSKDS PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD 100
STETPAGLTN LGATCYANSI LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ 150
LARLFAQLHS SKMAFIDSAP FIKTLELDNG VQQDSHEFLT LFLSLLEGSL 200
SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME DFYELELNIK 250
GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF 300
QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH 350
KGSAANSGHY VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSNKTD 400
QKPQGSSTAD SVTNDDNNSC HEAAFTSTME EMFSSTDAYM LMYKRIAKDE 450
NGIESNNISS NNSLPHHFVD EIDERNTSYV KECEEYESKK DVHLAYITER 500
RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP IITGVRVHSS 550
IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME 600
CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW 650
LRRKNVDIPS DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE 700
TSGMKIDDIV TFPSDSQPCG ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL 750
TSGKSLALHP GQKYYLVPSS WLSEWRAYIT ATGKNISSLP EPQSLEVTIN 800
SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES DWILFSEEWN 850
VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP 900
YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS 950
AAVPVPDRRT SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN 1000
QELHKGSVEI EDDFATLADK CIFPGDVLWV KDSEIYENRD IADEISEQKV 1050
VVQTEEGFRG TLLTSSASAQ LCQDISFSD 1079
Length:1,079
Mass (Da):119,883
Last modified:March 20, 2007 - v1
Checksum:i188CBC5ADA131036
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000128 Genomic DNA. Translation: EAY88874.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM000128 Genomic DNA. Translation: EAY88874.1 .

3D structure databases

ProteinModelPortali A2XDG4.
ModBasei Search...

Protein family/group databases

MEROPSi C19.A35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei A2XDG4.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000070740.

Family and domain databases

Gene3Di 3.30.2230.10. 2 hits.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.

Entry informationi

Entry nameiUBP26_ORYSI
AccessioniPrimary (citable) accession number: A2XDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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