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A2XDG4 (UBP26_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 26

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene names
Name:UBP26
ORF Names:OsI_010107
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length1079 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 3 DUSP domains.

Contains 1 ubiquitin-like domain.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   DomainRepeat
   Molecular functionHydrolase
Protease
Thiol protease
Gene Ontology (GO)
   Biological_processseed development

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionubiquitin-specific protease activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10791079Ubiquitin carboxyl-terminal hydrolase 26
PRO_0000293493

Regions

Domain106 – 446341USP
Domain495 – 598104DUSP 1
Domain613 – 715103DUSP 2
Domain738 – 862125DUSP 3
Domain961 – 103777Ubiquitin-like

Sites

Active site1151Nucleophile By similarity
Active site3591Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A2XDG4 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 188CBC5ADA131036

FASTA1,079119,883
        10         20         30         40         50         60 
MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC HGCHGNSKDS 

        70         80         90        100        110        120 
PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD STETPAGLTN LGATCYANSI 

       130        140        150        160        170        180 
LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ LARLFAQLHS SKMAFIDSAP FIKTLELDNG 

       190        200        210        220        230        240 
VQQDSHEFLT LFLSLLEGSL SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME 

       250        260        270        280        290        300 
DFYELELNIK GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF 

       310        320        330        340        350        360 
QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH KGSAANSGHY 

       370        380        390        400        410        420 
VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSNKTD QKPQGSSTAD SVTNDDNNSC 

       430        440        450        460        470        480 
HEAAFTSTME EMFSSTDAYM LMYKRIAKDE NGIESNNISS NNSLPHHFVD EIDERNTSYV 

       490        500        510        520        530        540 
KECEEYESKK DVHLAYITER RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP 

       550        560        570        580        590        600 
IITGVRVHSS IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME 

       610        620        630        640        650        660 
CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW LRRKNVDIPS 

       670        680        690        700        710        720 
DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE TSGMKIDDIV TFPSDSQPCG 

       730        740        750        760        770        780 
ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL TSGKSLALHP GQKYYLVPSS WLSEWRAYIT 

       790        800        810        820        830        840 
ATGKNISSLP EPQSLEVTIN SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES 

       850        860        870        880        890        900 
DWILFSEEWN VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP 

       910        920        930        940        950        960 
YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS AAVPVPDRRT 

       970        980        990       1000       1010       1020 
SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN QELHKGSVEI EDDFATLADK 

      1030       1040       1050       1060       1070 
CIFPGDVLWV KDSEIYENRD IADEISEQKV VVQTEEGFRG TLLTSSASAQ LCQDISFSD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM000128 Genomic DNA. Translation: EAY88874.1.

3D structure databases

ProteinModelPortalA2XDG4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.A35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneA2XDG4.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000070740.

Family and domain databases

Gene3D3.30.2230.10. 2 hits.
InterProIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMSSF143791. SSF143791. 2 hits.
PROSITEPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP26_ORYSI
AccessionPrimary (citable) accession number: A2XDG4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries