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A2XDG4

- UBP26_ORYSI

UniProt

A2XDG4 - UBP26_ORYSI

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Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

UBP26

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151NucleophilePROSITE-ProRule annotation
Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: InterPro
  2. ubiquitin thiolesterase activity Source: EnsemblPlants/Gramene

GO - Biological processi

  1. cell division Source: EnsemblPlants/Gramene
  2. cotyledon development Source: EnsemblPlants/Gramene
  3. embryonic pattern specification Source: EnsemblPlants/Gramene
  4. lipid storage Source: EnsemblPlants/Gramene
  5. photomorphogenesis Source: EnsemblPlants/Gramene
  6. primary shoot apical meristem specification Source: EnsemblPlants/Gramene
  7. protein ubiquitination Source: EnsemblPlants/Gramene
  8. regulation of cell cycle process Source: EnsemblPlants/Gramene
  9. regulation of cell differentiation Source: EnsemblPlants/Gramene
  10. regulation of flower development Source: EnsemblPlants/Gramene
  11. response to freezing Source: EnsemblPlants/Gramene
  12. seed dormancy process Source: EnsemblPlants/Gramene
  13. seed germination Source: EnsemblPlants/Gramene
  14. sister chromatid cohesion Source: EnsemblPlants/Gramene
  15. sugar mediated signaling pathway Source: EnsemblPlants/Gramene
  16. ubiquitin-dependent protein catabolic process Source: EnsemblPlants/Gramene
  17. vegetative to reproductive phase transition of meristem Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 26
Ubiquitin thioesterase 26
Ubiquitin-specific-processing protease 26
Gene namesi
Name:UBP26
ORF Names:OsI_010107
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Organism-specific databases

GrameneiA2XDG4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleolus Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10791079Ubiquitin carboxyl-terminal hydrolase 26PRO_0000293493Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA2XDG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 446341USPAdd
BLAST
Domaini495 – 598104DUSP 1PROSITE-ProRule annotationAdd
BLAST
Domaini613 – 715103DUSP 2PROSITE-ProRule annotationAdd
BLAST
Domaini738 – 862125DUSP 3PROSITE-ProRule annotationAdd
BLAST
Domaini961 – 103777Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 3 DUSP domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000070740.

Family and domain databases

Gene3Di3.30.2230.10. 2 hits.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2XDG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC
60 70 80 90 100
HGCHGNSKDS PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD
110 120 130 140 150
STETPAGLTN LGATCYANSI LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ
160 170 180 190 200
LARLFAQLHS SKMAFIDSAP FIKTLELDNG VQQDSHEFLT LFLSLLEGSL
210 220 230 240 250
SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME DFYELELNIK
260 270 280 290 300
GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF
310 320 330 340 350
QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH
360 370 380 390 400
KGSAANSGHY VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSNKTD
410 420 430 440 450
QKPQGSSTAD SVTNDDNNSC HEAAFTSTME EMFSSTDAYM LMYKRIAKDE
460 470 480 490 500
NGIESNNISS NNSLPHHFVD EIDERNTSYV KECEEYESKK DVHLAYITER
510 520 530 540 550
RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP IITGVRVHSS
560 570 580 590 600
IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME
610 620 630 640 650
CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW
660 670 680 690 700
LRRKNVDIPS DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE
710 720 730 740 750
TSGMKIDDIV TFPSDSQPCG ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL
760 770 780 790 800
TSGKSLALHP GQKYYLVPSS WLSEWRAYIT ATGKNISSLP EPQSLEVTIN
810 820 830 840 850
SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES DWILFSEEWN
860 870 880 890 900
VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP
910 920 930 940 950
YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS
960 970 980 990 1000
AAVPVPDRRT SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN
1010 1020 1030 1040 1050
QELHKGSVEI EDDFATLADK CIFPGDVLWV KDSEIYENRD IADEISEQKV
1060 1070
VVQTEEGFRG TLLTSSASAQ LCQDISFSD
Length:1,079
Mass (Da):119,883
Last modified:March 20, 2007 - v1
Checksum:i188CBC5ADA131036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA. Translation: EAY88874.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA. Translation: EAY88874.1 .

3D structure databases

ProteinModelPortali A2XDG4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei A2XDG4.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000070740.

Family and domain databases

Gene3Di 3.30.2230.10. 2 hits.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF06337. DUSP. 2 hits.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 3 hits.
PS50053. UBIQUITIN_2. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. 93-11.

Entry informationi

Entry nameiUBP26_ORYSI
AccessioniPrimary (citable) accession number: A2XDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3