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A2XDG4

- UBP26_ORYSI

UniProt

A2XDG4 - UBP26_ORYSI

Protein

Ubiquitin carboxyl-terminal hydrolase 26

Gene

UBP26

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Deubiquitinates H2BK143ub1 of histone H2B By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei115 – 1151NucleophilePROSITE-ProRule annotation
    Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. seed development Source: EnsemblPlants/Gramene
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A35.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 26 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 26
    Ubiquitin thioesterase 26
    Ubiquitin-specific-processing protease 26
    Gene namesi
    Name:UBP26
    ORF Names:OsI_010107
    OrganismiOryza sativa subsp. indica (Rice)
    Taxonomic identifieri39946 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

    Organism-specific databases

    GrameneiA2XDG4.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleolus Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10791079Ubiquitin carboxyl-terminal hydrolase 26PRO_0000293493Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA2XDG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini106 – 446341USPAdd
    BLAST
    Domaini495 – 598104DUSP 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini613 – 715103DUSP 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini738 – 862125DUSP 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini961 – 103777Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 3 DUSP domains.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000070740.

    Family and domain databases

    Gene3Di3.30.2230.10. 2 hits.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF06337. DUSP. 2 hits.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2XDG4-1 [UniParc]FASTAAdd to Basket

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    MSRPNTRNKS KRPRADDCES PSAVFKKIHS TGAITKGDIK QLYMVWKPVC     50
    HGCHGNSKDS PNCFCGLIPA ANGVRKSGLW QRTNEIIRAL GPNPSTDLRD 100
    STETPAGLTN LGATCYANSI LQCLYMNTSF RLGIFSLEPD ILKMHPVLDQ 150
    LARLFAQLHS SKMAFIDSAP FIKTLELDNG VQQDSHEFLT LFLSLLEGSL 200
    SHSKVPGART IVQHLFRGSV SHVTRCSSCG RDSEASSKME DFYELELNIK 250
    GLNNLEQSLD DYLSTEALDG ENQYFCESCQ KRVDATRCIK LRSLPPVVNF 300
    QLKRYVFLPK TTTKKKISSA FSFPGQLDMG KRLSNPSSSY TYGLSAILIH 350
    KGSAANSGHY VAHVKDESNG QWWEFDDEHV SKLGLHPFGE KPGKSSNKTD 400
    QKPQGSSTAD SVTNDDNNSC HEAAFTSTME EMFSSTDAYM LMYKRIAKDE 450
    NGIESNNISS NNSLPHHFVD EIDERNTSYV KECEEYESKK DVHLAYITER 500
    RQEVKSVLTE APATPEEDSY FWISTDWLRQ WADNVNPPSP IITGVRVHSS 550
    IDNSPIQCEH GKVPASKVTS MKRLSAGAWH KLFSKYGGGP TLSSDDFCME 600
    CLKDGAKNSV SADVYRDRKA SLRSIAEAAL AGNNPDGPLY FVSRPWLTQW 650
    LRRKNVDIPS DADSGPTIAL TCTHGNLLPE HASGAKRVTV PEDLWLFLYE 700
    TSGMKIDDIV TFPSDSQPCG ICSQQLSVVA SVEDNLRAVK LKQRQSHEKL 750
    TSGKSLALHP GQKYYLVPSS WLSEWRAYIT ATGKNISSLP EPQSLEVTIN 800
    SLICEKHSRL LQRPLDLVCK RGTITQKASN TDGLTMISES DWILFSEEWN 850
    VAHGKGLCAE IVFSKSSQDN LQSSEAVPIL VEDLDQSTND LSNDLGGREP 900
    YVRTDPEVCE ECIGEKESCA LVEKLNYQNE DIQVYLVRGK EAPKSIREAS 950
    AAVPVPDRRT SKRSRRTTSG NSISLKVSGS TTVYQLKLMI WESLGIVKEN 1000
    QELHKGSVEI EDDFATLADK CIFPGDVLWV KDSEIYENRD IADEISEQKV 1050
    VVQTEEGFRG TLLTSSASAQ LCQDISFSD 1079
    Length:1,079
    Mass (Da):119,883
    Last modified:March 20, 2007 - v1
    Checksum:i188CBC5ADA131036
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000128 Genomic DNA. Translation: EAY88874.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM000128 Genomic DNA. Translation: EAY88874.1 .

    3D structure databases

    ProteinModelPortali A2XDG4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei A2XDG4.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000070740.

    Family and domain databases

    Gene3Di 3.30.2230.10. 2 hits.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF06337. DUSP. 2 hits.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS51283. DUSP. 3 hits.
    PS50053. UBIQUITIN_2. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomes of Oryza sativa: a history of duplications."
      Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
      , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
      PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. 93-11.

    Entry informationi

    Entry nameiUBP26_ORYSI
    AccessioniPrimary (citable) accession number: A2XDG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3