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Protein

Putative laccase-18

Gene

LAC18

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Copper 1By similarity1
Metal bindingi89Copper 2By similarity1
Metal bindingi132Copper 2By similarity1
Metal bindingi134Copper 3By similarity1
Metal bindingi488Copper 4Sequence analysis1
Metal bindingi491Copper 1By similarity1
Metal bindingi493Copper 3By similarity1
Metal bindingi550Copper 3By similarity1
Metal bindingi551Copper 4Sequence analysis1
Metal bindingi552Copper 2By similarity1
Metal bindingi556Copper 4Sequence analysis1
Metal bindingi561Copper 4Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative laccase-18 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 18
Diphenol oxidase 18
Urishiol oxidase 18
Gene namesi
Name:LAC18
ORF Names:OsI_009829
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000029190230 – 595Putative laccase-18Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

ExpressionAtlasiA2XCN6 differential

Interactioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA011887-PA

Structurei

3D structure databases

ProteinModelPortaliA2XCN6
SMRiA2XCN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 153Plastocyanin-like 1Add BLAST117
Domaini162 – 316Plastocyanin-like 2Add BLAST155
Domaini429 – 571Plastocyanin-like 3Add BLAST143

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
OMAiFMVHEMN
OrthoDBiEOG093605N6

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 4 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2XCN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLSTAASL FGVVVAATAL AMAVVGGEAA VVEQTFMVHE MNVTHLCNTT
60 70 80 90 100
KIYVVNGRFP GPTVDVTEGD TVVVHVINRL PHGLTIHWHG VRQMRSCWAD
110 120 130 140 150
GAGYVTECPI HPGGEKTYRF NVTGQVGTLW WHAHVTCLRA TINGAFIIRP
160 170 180 190 200
RDGKYPFPTP AKDVPIIIGE WWELDLIELD RRMLDGNFDD NPLSATINGK
210 220 230 240 250
LGDLSNCSGT VEESFVLDVK RGESYLLRVI NTALFSEYYF KVAGHTFTVV
260 270 280 290 300
GADGNYLTPY KTDMVTVAPG EAIDVLMFAD APPAYYHMVA LANQPPPPDL
310 320 330 340 350
QIPQLTSRGL VRYTGAAMDS NNLPMPMPVM PDQHNTMPSY YFRRNLTGLA
360 370 380 390 400
LPEQQQRHRV PAHVDERLLI TLGLGSICRG GNTTTCKRGR SPETVVVATM
410 420 430 440 450
NNVSFHHTNA TALLEHYYDG TPEGVYTEDF PVRPPRPFNY TDRELIPAGP
460 470 480 490 500
LEAALEPTAK AMRLRRFRYN ASVEIVFQST TLLQSDSNPM HLHGYDVFVL
510 520 530 540 550
AQGLGNFDPK RDVEKFNYHN PQLRNTVQVP RGGWAAVRFL TDNPGMWYLH
560 570 580 590
CHFEFHIIMG MATAFIVEDG PTPETSLPPP PPEFKRCGTN GLSQP
Length:595
Mass (Da):66,058
Last modified:March 20, 2007 - v1
Checksum:iA01F29581F8EE0BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA Translation: EAY88596.1

Genome annotation databases

EnsemblPlantsiBGIOSGA011887-TA; BGIOSGA011887-PA; BGIOSGA011887
GrameneiBGIOSGA011887-TA; BGIOSGA011887-PA; BGIOSGA011887

Similar proteinsi

Entry informationi

Entry nameiLAC18_ORYSI
AccessioniPrimary (citable) accession number: A2XCN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 20, 2007
Last modified: December 20, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health