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Protein

Putative laccase-18

Gene

LAC18

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Copper 1By similarity1
Metal bindingi89Copper 2By similarity1
Metal bindingi132Copper 2By similarity1
Metal bindingi134Copper 3By similarity1
Metal bindingi488Copper 4Sequence analysis1
Metal bindingi491Copper 1By similarity1
Metal bindingi493Copper 3By similarity1
Metal bindingi550Copper 3By similarity1
Metal bindingi551Copper 4Sequence analysis1
Metal bindingi552Copper 2By similarity1
Metal bindingi556Copper 4Sequence analysis1
Metal bindingi561Copper 4Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative laccase-18 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 18
Diphenol oxidase 18
Urishiol oxidase 18
Gene namesi
Name:LAC18
ORF Names:OsI_009829
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000007015 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000029190230 – 595Putative laccase-18Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi402N-linked (GlcNAc...)Sequence analysis1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1
Glycosylationi470N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi39946.BGIOSGA011887-PA.

Structurei

3D structure databases

ProteinModelPortaliA2XCN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 153Plastocyanin-like 1Add BLAST117
Domaini162 – 316Plastocyanin-like 2Add BLAST155
Domaini429 – 571Plastocyanin-like 3Add BLAST143

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
OMAiHHTNATA.
OrthoDBiEOG093605N6.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2XCN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLSTAASL FGVVVAATAL AMAVVGGEAA VVEQTFMVHE MNVTHLCNTT
60 70 80 90 100
KIYVVNGRFP GPTVDVTEGD TVVVHVINRL PHGLTIHWHG VRQMRSCWAD
110 120 130 140 150
GAGYVTECPI HPGGEKTYRF NVTGQVGTLW WHAHVTCLRA TINGAFIIRP
160 170 180 190 200
RDGKYPFPTP AKDVPIIIGE WWELDLIELD RRMLDGNFDD NPLSATINGK
210 220 230 240 250
LGDLSNCSGT VEESFVLDVK RGESYLLRVI NTALFSEYYF KVAGHTFTVV
260 270 280 290 300
GADGNYLTPY KTDMVTVAPG EAIDVLMFAD APPAYYHMVA LANQPPPPDL
310 320 330 340 350
QIPQLTSRGL VRYTGAAMDS NNLPMPMPVM PDQHNTMPSY YFRRNLTGLA
360 370 380 390 400
LPEQQQRHRV PAHVDERLLI TLGLGSICRG GNTTTCKRGR SPETVVVATM
410 420 430 440 450
NNVSFHHTNA TALLEHYYDG TPEGVYTEDF PVRPPRPFNY TDRELIPAGP
460 470 480 490 500
LEAALEPTAK AMRLRRFRYN ASVEIVFQST TLLQSDSNPM HLHGYDVFVL
510 520 530 540 550
AQGLGNFDPK RDVEKFNYHN PQLRNTVQVP RGGWAAVRFL TDNPGMWYLH
560 570 580 590
CHFEFHIIMG MATAFIVEDG PTPETSLPPP PPEFKRCGTN GLSQP
Length:595
Mass (Da):66,058
Last modified:March 20, 2007 - v1
Checksum:iA01F29581F8EE0BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA. Translation: EAY88596.1.

Genome annotation databases

EnsemblPlantsiBGIOSGA011887-TA; BGIOSGA011887-PA; BGIOSGA011887.
GrameneiBGIOSGA011887-TA; BGIOSGA011887-PA; BGIOSGA011887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA. Translation: EAY88596.1.

3D structure databases

ProteinModelPortaliA2XCN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA011887-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiBGIOSGA011887-TA; BGIOSGA011887-PA; BGIOSGA011887.
GrameneiBGIOSGA011887-TA; BGIOSGA011887-PA; BGIOSGA011887.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
OMAiHHTNATA.
OrthoDBiEOG093605N6.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC18_ORYSI
AccessioniPrimary (citable) accession number: A2XCN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.