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Protein

Alcohol dehydrogenase class-3

Gene

ADHIII

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Zinc 1; catalyticBy similarity1
Binding sitei50NADBy similarity1
Binding sitei51SubstrateBy similarity1
Metal bindingi71Zinc 1; catalyticBy similarity1
Binding sitei71SubstrateBy similarity1
Metal bindingi72Zinc 1By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei274NAD; via carbonyl oxygenBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3
Nucleotide bindingi322 – 324NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1By similarity)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284By similarity)
Gene namesi
Name:ADHIII
ORF Names:OsI_009236
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914571 – 381Alcohol dehydrogenase class-3Add BLAST381

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA009283-PA.

Structurei

3D structure databases

ProteinModelPortaliA2XAZ3.
SMRiA2XAZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
OMAiCIGNVNT.
OrthoDBiEOG09360BVQ.

Family and domain databases

CDDicd08300. alcohol_DH_class_III. 1 hit.
InterProiView protein in InterPro
IPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like_sf.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

A2XAZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTQGQVI TCKAAVAWEA NKPMTIEDVQ VAPPQAGEVR VKILFTALCH
60 70 80 90 100
TDHYTWSGKD PEGLFPCILG HEAAGIVESV GEGVTEVQPG DHVIPCYQAE
110 120 130 140 150
CRECKFCKSG KTNLCGKVRA ATGVGVMMND RKSRFSINGK PIYHFMGTST
160 170 180 190 200
FSQYTVVHDV SVAKINPQAP LDKVCLLGCG VSTGLGAVWN TAKVEAGSIV
210 220 230 240 250
AIFGLGTVGL AVAEGAKSAG ASRIIGIDID SKKFDVAKNF GVTEFVNPKD
260 270 280 290 300
HDKPIQQVIV DLTDGGVDYS FECIGNVSVM RSALECCHKG WGTSVIVGVA
310 320 330 340 350
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR SQVPWLVEKY LNKEIKVDEY
360 370 380
VTHSMNLTDI NKAFDLLHEG GCLRCVLATD K
Length:381
Mass (Da):40,795
Last modified:March 20, 2007 - v1
Checksum:i5B8A11601EDB30CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48L → F in AAB19117 (PubMed:9215914).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77637 Genomic DNA. Translation: AAB19117.1.
CM000127 Genomic DNA. Translation: EAY88003.1.
PIRiT04164.

Genome annotation databases

EnsemblPlantsiBGIOSGA009283-TA; BGIOSGA009283-PA; BGIOSGA009283.
GrameneiBGIOSGA009283-TA; BGIOSGA009283-PA; BGIOSGA009283.

Similar proteinsi

Entry informationi

Entry nameiADHX_ORYSI
AccessioniPrimary (citable) accession number: A2XAZ3
Secondary accession number(s): P93436, Q6K6C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families