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A2XAZ3 (ADHX_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
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Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase class-3
EC=1.1.1.1
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase
Short name=FALDH
Short name=FDH
Short name=GSH-FDH
EC=1.1.1.-
S-(hydroxymethyl)glutathione dehydrogenase
EC=1.1.1.284
Gene names
Name:ADHIII
ORF Names:OsI_009236
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Alcohol dehydrogenase class-3
PRO_0000291457

Sites

Metal binding491Zinc 1; catalytic By similarity
Metal binding711Zinc 1; catalytic By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1071Zinc 2 By similarity
Metal binding1151Zinc 2 By similarity
Metal binding1791Zinc 1; catalytic By similarity

Experimental info

Sequence conflict481L → F in AAB19117. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A2XAZ3 [UniParc].

Last modified March 20, 2007. Version 1.
Checksum: 5B8A11601EDB30CE

FASTA38140,795
        10         20         30         40         50         60 
MASSTQGQVI TCKAAVAWEA NKPMTIEDVQ VAPPQAGEVR VKILFTALCH TDHYTWSGKD 

        70         80         90        100        110        120 
PEGLFPCILG HEAAGIVESV GEGVTEVQPG DHVIPCYQAE CRECKFCKSG KTNLCGKVRA 

       130        140        150        160        170        180 
ATGVGVMMND RKSRFSINGK PIYHFMGTST FSQYTVVHDV SVAKINPQAP LDKVCLLGCG 

       190        200        210        220        230        240 
VSTGLGAVWN TAKVEAGSIV AIFGLGTVGL AVAEGAKSAG ASRIIGIDID SKKFDVAKNF 

       250        260        270        280        290        300 
GVTEFVNPKD HDKPIQQVIV DLTDGGVDYS FECIGNVSVM RSALECCHKG WGTSVIVGVA 

       310        320        330        340        350        360 
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR SQVPWLVEKY LNKEIKVDEY VTHSMNLTDI 

       370        380 
NKAFDLLHEG GCLRCVLATD K

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the Arabidopsis and rice formaldehyde dehydrogenase genes: implications for the origin of plant ADH enzymes."
Dolferus R., Osterman J.C., Peacock W.J., Dennis E.S.
Genetics 146:1131-1141(1997) [PubMed: 9215914] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. IR36.
[2]"The genomes of Oryza sativa: a history of duplications."
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. expand/collapse author list , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
PLoS Biol. 3:266-281(2005) [PubMed: 15685292] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. 93-11.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U77637 Genomic DNA. Translation: AAB19117.1.
CM000127 Genomic DNA. Translation: EAY88003.1.
PIRT04164.
UniGeneOs.59290.

3D structure databases

ProteinModelPortalA2XAZ3.
SMRA2XAZ3. Positions 8-377.
ModBaseSearch...

Protein-protein interaction databases

STRINGA2XAZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP93436.

Phylogenomic databases

GeneTreeEPGT00050000000862.
HOGENOMHBG753318.
PhylomeDBA2XAZ3.

Family and domain databases

InterProIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 2 hits.
TIGRFAMsTIGR02818. Adh_III_F_hyde. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADHX_ORYSI
AccessionPrimary (citable) accession number: A2XAZ3
Secondary accession number(s): P93436, Q6K6C1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 20, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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